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  4. Recombinant Mouse Rapamycin-insensitive companion of mTOR (Rictor), partial

Recombinant Mouse Rapamycin-insensitive companion of mTOR (Rictor), partial

  • 中文名称：
    小鼠Rictor重组蛋白
  • 货号：
    CSB-YP744164MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Rictor重组蛋白
  • 货号：
    CSB-EP744164MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Rictor重组蛋白
  • 货号：
    CSB-EP744164MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Rictor重组蛋白
  • 货号：
    CSB-BP744164MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Rictor重组蛋白
  • 货号：
    CSB-MP744164MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Rictor
  • Uniprot No.：
    Q6QI06
  • 别名：
    Rictor; Kiaa1999; Rapamycin-insensitive companion of mTOR; AVO3 homolog; mAVO3; Protein pianissimo
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development.
  • 基因功能参考文献：
    1. Rictor striatal levels could counteract neuronal dysfunction induced by mutant huntingtin. PMID: 29460266
    2. Data provides evidence that rictor protein binds to hnrnp protein. PMID: 28106162
    3. Down-regulation of miR-142-3p inhibited ECs apoptosis and atherosclerotic development by up-regulating the expression of Rictor and activating the Akt/eNOS signaling pathway. PMID: 29949787
    4. Rictor deficiency increases macrophage/neutrophil infiltration and cytokine/chemokine release during hepatic Ischemia/Reperfusion injury. In addition, Rictor deficiency affected MAPK activation in lipopolysaccharide -treated RAW264.7 cells. PMID: 29550823
    5. Study examined mTOR variables, with attention to mTORC2 (Rictor), in Alzheimer's disease (AD) brain samples and in two mouse models, and made comparisons with results from cell- and in vitro-based experiments where Abeta is either expressed or peptide added. Authors conclude that striking a new balance by restoring mTORC2 abundance and/or inhibition of mTORC1 has therapeutic potential in AD. PMID: 28035937
    6. Rictor-deficient keratinocytes exhibited changes in global gene expression profiles consistent with metabolic alterations and enhanced stress tolerance, a shift in cell catabolic processes from glycids and lipids to glutamine consumption and increased production of mitochondrial reactive oxygen species. PMID: 28211872
    7. Osteoblast differentiation was reduced, with down-regulation of mTORC2 signaling activity in primary cultures of osteoblasts that did not contain rictor. PMID: 27262777
    8. To determine the role of mTORC2 signaling in myelinogenesis, we generated a mouse lacking the critical mTORC2 component Rictor in oligodendrocyte precursors (OPCs). Targeted deletion of Rictor in these cells decreases and delays the expression of myelin related proteins and reduces the size of cerebral white matter tracts PMID: 29161318
    9. results demonstrated that Rictor/mTORC2 might play an important role in the cardiomyocyte differentiation of mES cells. PMID: 28123351
    10. Increased oxidative stress leads to oxidation of mTORC2 complex protein Rictor. PMID: 28986255
    11. Rictor positively regulates B cell receptor (BCR) signaling via up-regulating Btk and down-regulating SH2-containing inositol phosphatase. Rictor regulates BCR signaling via actin reorganization. PMID: 28821013
    12. our present findings highlighted a pivotal regulatory axis of Rictor-FoxO3a in maintaining quiescence and the stemness of LSCs. PMID: 27499138
    13. These findings reveal a novel functional pathway important for age-related bone loss and support for miR-218 and Rictor as potential targets for therapeutic intervention for age-related osteoporosis treatment. PMID: 27735936
    14. this study shows that Rictor is required for NKT-17 cell development and normal iNKT-cell cytolytic function PMID: 28078715
    15. data suggest that Rictor/mTORC2 controls an amino acid-sensitive checkpoint that allows T cells to determine whether the microenvironment contains sufficient resources for daughter cell generation. PMID: 27799302
    16. Loss of DNMT3B results in hypomethylation of the miR-196b promoter and increased miR-196b expression, which directly targets the mTORC2 component Rictor. PMID: 26923591
    17. Rictor in the limb mesenchymal lineage is required for the normal response to the anti-sclerostin therapy in both bone formation and resorption. PMID: 26780446
    18. Low RICTOR expression was detected in quiescent, confluent mouse aortic endothelial cells, whereas high doses of FGF2 induced high RICTOR expression that was associated with strong mTORC2-specific protein kinase Ca and AKT phosphorylation PMID: 26635098
    19. analysis of mTORC2 components mTOR, Rictor and mSin1 reveals diurnal variation in mouse perivascular adipose tissue PMID: 27016480
    20. Adipose tissue mTORC2 regulates via Rictor ChREBP-driven de novo lipogenesis and hepatic glucose metabolism. PMID: 27098609
    21. downregulation by microRNA-15b/16 is required for induction of regulatory T cells PMID: 26538392
    22. Rictor is essential for the generation of type II IFN-dependent antiviral and antiproliferative responses and that it controls the generation of type II IFN-suppressive effects on normal and malignant hematopoiesis PMID: 26645692
    23. Study suggests that Rictor/mTORC2 signaling activation mediates TGFbeta1-induced fibroblast activation and contributes to the development of kidney fibrosis. PMID: 25970154
    24. RICTOR/MTORC2-AKT can integrate convergent hormonal and metabolic signals to provide coordinated and sensitive regulation of hepatic FOXO1-target gene expression. PMID: 26453307
    25. endogenous Rictor/mTORC2 protects against cisplatin-induced acute kidney injury, probably mediated by promoting cell survival through Akt signaling activation and induction of autophagy PMID: 24451322
    26. Together, these findings establish the importance of Rictor/mTORC2 signaling in Sertoli cell function and spermatogenesis through the maintenance of Sertoli cell cytoskeletal dynamics, BTB integrity, and cell polarity. PMID: 26360620
    27. Rictor regulates the development of early B cells. PMID: 25084011
    28. Rictor in Myf5 lineage shifts BAT metabolism to a more oxidative and less lipogenic state and is required for lipognesis. PMID: 25001283
    29. The results of this study findings implicate mTORC2 signaling as a novel pathway regulating striatal DA tone and D2R signaling. PMID: 26063917
    30. Data indicate that s transmembrane molecule in hematopoietic progenitor cells that physically interacts with and inhibits RICTOR, an essential component of mTORC2. PMID: 25418727
    31. Depletion of RICTOR significantly decreases male, but not female, lifespan. RICTOR depletion on lifespan is independent of the role of hepatic mTORC2 in promoting glucose tolerance. PMID: 25059582
    32. Myeloid-specific Rictor deletion induces M1 macrophage polarization and potentiates in vivo pro-inflammatory response to lipopolysaccharide. PMID: 24740015
    33. Our results collectively indicate key roles of Rictor/mTORC2 in folliculogenesis, follicle survival, and female fertility and support the utility of oocyte-specific Rictor knock-out mice as a novel model for POF PMID: 25564616
    34. Deleting Rictor suppressed leukemia progression by arresting more leukemic cells at G0 phase. Rictor deletion led to overexpression of chemotaxis-related genes involved in homing of Rictor-deficient T-ALL cells to the spleen but not the bone marrow. PMID: 25201756
    35. Data (from knockout mice) suggest GPAT4- (glycerol-3-phosphate acyltransferase-4-)derived phosphatidic acid impairs insulin signaling in liver/contributes to hepatic insulin resistance via interaction of Rictor/mTOR (mechanistic target of rapamycin). PMID: 24939733
    36. mTORC2 is involved in the co/posttranslational processing of membrane receptors and impacts development via regulation of the quantity and quality of receptors important for cell differentiation. PMID: 24981454
    37. these findings provide evidence for critical functions for Rictor/Sin1 complexes in type I IFN signaling and the generation of type I IFN antineoplastic responses. PMID: 24469448
    38. The results of this study showed that loss of riptor in oligodendrocytes results in differential dysmyelination in specific areas of the CNS, with the greatest impact on spinal cord myelination. PMID: 24671993
    39. the findings establish Rictor as an important signal relay in B-cell homeostasis, fate, and functions. PMID: 23958952
    40. Identify rictor/mTORC2 as a critical regulator of perivascular adipose tissue-directed protection of normal vascular tone. PMID: 23868942
    41. Rictor regulates cell migration by suppressing RhoGDI2. PMID: 22777355
    42. Neurons were smaller and their morphology and function were strongly affected in rictor deficient mice. PMID: 23569215
    43. Rictor CKO mice are hyperactive and have reduced anxiety-like behavior PMID: 23049074
    44. These data collectively establish Rictor as a novel oncoprotein and support the role of dysregulated Rictor expression in gliomagenesis via mTOR-dependent and mTOR-independent mechanisms. PMID: 23077666
    45. Our data demonstrated that targeted mutation of Rictor in the thymocytes drastically reduced the thymic cellularity PMID: 22815285
    46. rictor induced phosphorylation of AKT1 in Ser473 is required for TORC2 function in early development of mouse embryos PMID: 22057724
    47. PI3K/AKT signaling through mTORC2/pAKT-S473 plays a key role in maintaining normal beta-cell mass. PMID: 21266327
    48. nephrilin disrupted the association of Rictor with insulin receptor substrate-2 and nuclear compartmentalization PMID: 20545557
    49. Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction. PMID: 20832730
    50. propose that amplified norepinephrine transporter function in rictor KO mice enhances accumulation of both norepinephrine and dopamine within the noradrenergic neuron PMID: 20543991

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  • 蛋白家族：
    RICTOR family
  • 数据库链接：

    KEGG: mmu:78757

    STRING: 10090.ENSMUSP00000051809

    UniGene: Mm.275811

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