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  4. Recombinant Mouse Rab effector MyRIP (Myrip), partial

Recombinant Mouse Rab effector MyRIP (Myrip), partial

  • 中文名称：
    小鼠Myrip重组蛋白
  • 货号：
    CSB-YP815669MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Myrip重组蛋白
  • 货号：
    CSB-EP815669MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Myrip重组蛋白
  • 货号：
    CSB-EP815669MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Myrip重组蛋白
  • 货号：
    CSB-BP815669MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Myrip重组蛋白
  • 货号：
    CSB-MP815669MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Myrip
  • Uniprot No.：
    Q8K3I4
  • 别名：
    Myrip; Slac2c; Rab effector MyRIP; Exophilin-8; Myosin-VIIa- and Rab-interacting protein; Synaptotagmin-like protein lacking C2 domains C; SlaC2-c; Slp homolog lacking C2 domains c
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor proteins MYO5A and MYO7A. May link RAB27A-containing vesicles to actin filaments. Functions as a protein kinase A-anchoring protein (AKAP). May act as a scaffolding protein that links PKA to components of the exocytosis machinery, thus facilitating exocytosis, including insulin release.
  • 基因功能参考文献：
    1. Exophilin8 transiently clusters insulin granules at the actin-rich cell cortex prior to exocytosis PMID: 21441305
    2. Synaptotagmin-like protein homologue lacking C2 domains-c) is a novel linker protein that interacts with Rab27, myosin Va/VIIa, and actin PMID: 12221080
    3. Slac2-c acts as a functional myosin VIIa receptor and the Rab27A.Slac2-c x myosin VIIa tripartite protein complex regulates the transport of retinal melanosomes in pigment epithelium cells PMID: 15927964
    4. The present results provide evidence from live retinal pigment epithelium cells that the RAB27A-MYRIP-MYO7A complex functions in melanosome motility. PMID: 17352418
    5. Results suggest that the Rab27a-Myrip-MyoVIIa complex regulates tethering of melanosomes onto actin filaments, a process that ensures melanosome movement towards the cell periphery. PMID: 17451552
    6. indicate that MyRIP functions as a scaffolding protein that links protein kinase A to components of the exocytosis machinery PMID: 17827149
    7. Myrip is a versatile Rab27a-associated myosin-activating protein that mediates cellular activation of MyoVa and MyoVIIa via non-overlapping domains. PMID: 19317802
    8. Slac2-c/MyRIP contains an N-terminal Slp homology domain (SHD) and functions as a linker protein that interacts with myosin Rab27A/B, VIIa/Va, and actin. PMID: 12221080

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  • 亚细胞定位：
    Cytoplasm. Cytoplasm, perinuclear region. Cytoplasmic vesicle, secretory vesicle. Melanosome.
  • 组织特异性：
    Detected in brain, skin, heart, lung, adrenal medulla, pancreas, intestine, liver, kidney, skeletal muscle and testis. Detected in cochlear and vestibular hair cells in the inner ear, and in photoreceptor and pigment epithelium cells in the retina.
  • 数据库链接：

    KEGG: mmu:245049

    STRING: 10090.ENSMUSP00000046891

    UniGene: Mm.100936

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