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  4. Recombinant Mouse RGM domain family member B (Rgmb)

Recombinant Mouse RGM domain family member B (Rgmb)

  • 中文名称：
    小鼠Rgmb重组蛋白
  • 货号：
    CSB-YP756026MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Rgmb重组蛋白
  • 货号：
    CSB-EP756026MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Rgmb重组蛋白
  • 货号：
    CSB-EP756026MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Rgmb重组蛋白
  • 货号：
    CSB-BP756026MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Rgmb重组蛋白
  • 货号：
    CSB-MP756026MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Rgmb
  • Uniprot No.：
    Q7TQ33
  • 别名：
    Rgmb; RGM domain family member B; DRG11-responsive axonal guidance and outgrowth of neurite; DRAGON
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    49-415
  • 氨基酸序列
    GD CQQPTQCRIQ KCTTDFVALT AHLNSAADGF DSEFCKALRA YAGCTQRTSK ACRGNLVYHS AVLGISDLMS QRNCSKDGPT SSTNPEVTHD PCNYHSHGGV REHGGGDQRP PNYLFCGLFG DPHLRTFKDH FQTCKVEGAW PLIDNNYLSV QVTNVPVVPG SSATATNKVT IIFKAQHECT DQKVYQAVTD DLPAAFVDGT TSGGDGDVKS LHIVEKESGR YVEMHARYIG TTVFVRQLGR YLTLAIRMPE DLAMSYEESQ DLQLCVNGCP MSECIDDGQG QVSAILGHSL PHTTSVQAWP GYTLETASTQ CHEKMPVKDI YFQSCVFDLL TTGDANFTAA AHSALEDVEA LHPRKERWHI FPSSC
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Member of the repulsive guidance molecule (RGM) family that contributes to the patterning of the developing nervous system. Acts as a bone morphogenetic protein (BMP) coreceptor that potentiates BMP signaling. Promotes neuronal adhesion. May inhibit neurite outgrowth.
  • 基因功能参考文献：
    1. Specific knockout of Rgmb in tubular cells increased MLKL expression at the apical membrane of proximal tubular cells and induced more tubular cell death and more severe renal dysfunction compared with wild-type mice. PMID: 29382757
    2. Study focused on the RGMa and RGMb expression in cerebral cortex and hippocampus of newborn mice with maternal lead exposure. RGMa and RGMb expression in hippocampus were upregulated in lead exposed groups, and the RGMa and RGMb expression in cerebral cortex were also higher. PMID: 27545491
    3. These results reveal RGMb as a novel regulator for Autosomal dominant polycystic kidney disease by promoting renal tubule branching and regulating BMP signaling pathway. PMID: 27575743
    4. The results indicate that RGMB-neogenin-mediated cell-cell interactions between newly born neurons and progenitor cells control the ratio of glia and neurons produced in the developing olfactory epithelium. PMID: 27143755
    5. Data show that Dragon expression was increased in colon cancer tissues compared to control tissues in CAC mouse model and in human patients. PMID: 26029998
    6. RGMb is a novel binding partner for PD-L2 and its engagement with PD-L2 promotes respiratory tolerance. PMID: 24752301
    7. Dragon may impair tubular epithelial integrity and induce epithelial apoptosis both in vitro and in vivo. PMID: 24052264
    8. Strong expression of RGMa, RGMb and Neogenin protein was found on several major axon tracts such as the primary olfactory projections, anterior commissure and fasciculus retroflexus. PMID: 23457482
    9. Our data suggest a positive modulatory contribution of RGMb and bone morphogenetic protein signaling to neurite extension in vitro and early axonal regrowth after nerve injury in vivo and a negative effect of Noggin. PMID: 22171041
    10. Dragon is an important negative regulator of IL-6 expression in immune cells; Dragon-deficient mice may be a useful model for studying immune and inflammatory disorders. PMID: 21187450
    11. Predominantly expressed in developing neuron. PMID: 14678836
    12. A gene with promoter binding to the DNA binding domain of DRG11; encodes a conserved developmentally regulated membrane-associated glycosyl-phosphatidylinositol-anchored protein which promotes dorsal root ganglion neuron adhesion. PMID: 14985445
    13. The direct interaction of DRAGON with bone morphogenetic protein (BMP) ligands and receptors indicates that it is a BMP co-receptor that potentiates BMP signaling. PMID: 15671031
    14. Dragon protein modulates bone morphogenetic protein signaling in cells from reproductive tissues. PMID: 15890774
    15. May be involved in cell migration, differentiation, and apoptosis with similar cellular mechanisms as described in the central nervous system. PMID: 16032658
    16. a higher expression of RGMa, RGMb and neogenin was found in the retinas of all glaucoma-affected mice; a higher RGMa and RGMb expression were detected in the optic nerves of glaucoma-affected DBA/2J-mice older than 11M PMID: 17942375
    17. These findings indicate that DRAGON may be an inhibitor of BMP signaling in C2C12 myoblasts. PMID: 19422419

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  • 亚细胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor. Membrane raft.
  • 蛋白家族：
    Repulsive guidance molecule (RGM) family
  • 组织特异性：
    Detected in neonatal and adult dorsal root ganglion sensory neurons, spinal cord, and brain (at protein level). Also expressed at high levels in retinal ganglion cells of developing mouse, extending to the optic nerve (at protein level). Expressed in test
  • 数据库链接：

    KEGG: mmu:68799

    STRING: 10090.ENSMUSP00000126177

    UniGene: Mm.293466

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