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  4. Recombinant Mouse RB1-inducible coiled-coil protein 1 (Rb1cc1), partial

Recombinant Mouse RB1-inducible coiled-coil protein 1 (Rb1cc1), partial

  • 中文名称：
    小鼠Rb1cc1重组蛋白
  • 货号：
    CSB-YP861707MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Rb1cc1重组蛋白
  • 货号：
    CSB-EP861707MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Rb1cc1重组蛋白
  • 货号：
    CSB-EP861707MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Rb1cc1重组蛋白
  • 货号：
    CSB-BP861707MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Rb1cc1重组蛋白
  • 货号：
    CSB-MP861707MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Rb1cc1
  • Uniprot No.：
    Q9ESK9
  • 别名：
    Rb1cc1; Cc1; Kiaa0203; RB1-inducible coiled-coil protein 1; Coiled-coil-forming protein 1; FAK family kinase-interacting protein of 200 kDa; FIP200; LaXp180
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Involved in autophagy. Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1. Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy. Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis. Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways. Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111. Functions as a DNA-binding transcription factor. Is a potent regulator of the RB1 pathway through induction of RB1 expression. Plays a crucial role in muscular differentiation. Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis.
  • 基因功能参考文献：
    1. Genetic FIP200 protein deletion impairs autophagy induction and causes T cell apoptosis. PMID: 29150439
    2. Suggest that autophagy gene FIP200 plays a crucial role in regulating neurogenesis and restricting local immune response in postnatal neural stem cells through non-cell autonomous mechanisms. PMID: 28634261
    3. residues 582-585 (LQFL) in FIP200 are required for interaction with Atg13, and mutation of these residues to AAAA (designated the FIP200-4A mutant) abolished its canonical autophagy function in vitro. PMID: 27013233
    4. Deletion of autophagy inducer RB1CC1 results in degeneration of the retinal pigment epithelium PMID: 26075877
    5. Data indicate that fip200 protein deficiency was responsible for high mobility group protein HMGB1 translocation in alveolar macrophage MH-S cells. PMID: 24923305
    6. these data identify FIP200 as an important regulator of bone development. PMID: 23633228
    7. Fip200 regulates Atg16L1 membrane targeting via direct interaction with Atg16L1. PMID: 23392225
    8. The data of this study revealed that FIP200-mediated autophagy contributes to the maintenance and functions of NSCs through regulation of oxidative state. PMID: 23542691
    9. RB1CC1 protein suppresses type II collagen synthesis in chondrocytes and causes dwarfism PMID: 22049074
    10. these results identify a new function for FIP200 in the regulation of DNA damage response and cell survival through its activity in autophagy PMID: 21807966
    11. RB1CC1 thus appears to play a unique role as a modulator of TGF-beta signaling by restricting substrate specificity of Arkadia. PMID: 21795712
    12. Deletion of FIP200 resulted in multiple autophagy defects including accumulation of ubiquitinated protein aggregates and p62/SQSTM1, deficient LC3 conversion, and increased number of mitochondria with abnormal morphology in tumor cells PMID: 21764854
    13. data identify FIP200 as a key intrinsic regulator of fetal hematopoietic stem cells PMID: 20716775
    14. FIP200 has a role in the regulation of neuronal homeostasis through its function in autophagy in vivo PMID: 19940130
    15. expression and promoter activities of RB1CC1 in developing murine and human tissues; RB1CC1 expression is controlled more stringently by modification at intron 1 in humans than in mice PMID: 15375585
    16. FIP200 (Rb1cc1, RB1CC1) is shown to interact with the TSC1-TSC2 complex and this interaction leads to increased S6K activity and cell growth. PMID: 16043512
    17. FIP200 functions as a regulatory node to couple two important signaling pathways to regulate cell growth and survival during mouse embryogenesis. PMID: 17015619
    18. RB1CC1 insufficiency causes neuronal atrophy through mTOR signaling alteration. PMID: 17706618
    19. Rb1cc1 is a target gene of ERRalpha, driven by a novel type of recognition sequence. PMID: 18039682
    20. provide the first evidence for the existence of a close-spatially controlled-mode of regulation of FIP200 and PIASy nucleocytoplasmic functions PMID: 18285457
    21. These results suggest that FIP200 is a novel mammalian autophagy factor that functions together with ULKs. PMID: 18443221
    22. The role of the ULK-FIP200 complex in autophagy and the possibility that FIP200 functions as a mammalian counterpart of Atg17, is reported. PMID: 18981720
    23. Inactivation of FIP200 leads to inflammatory skin disorder, but not tumorigenesis, in conditional knock-out mouse models. PMID: 19106106
    24. mTORC1 suppresses autophagy through direct regulation of the approximately 3-MDa ULK1-Atg13-FIP200 complex. PMID: 19211835
    25. ATG13 and ULK1 are phosphorylated by the mTOR pathway in a nutrient starvation-regulated manner, indicating that the ULK1.ATG13.FIP200 complex acts as a node for integrating incoming autophagy signals into autophagosome biogenesis. PMID: 19258318
    26. Rb1cc1 expression is a prerequisite for the induction of RB1 and myosin heavy chain. Rb1cc1 plays a crucial role in muscular differentiation and function. PMID: 15968549

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  • 亚细胞定位：
    Nucleus. Cytoplasm, cytosol. Cytoplasm. Preautophagosomal structure. Lysosome.
  • 组织特异性：
    Expressed abundantly in heart and testis, and moderately in kidney, liver and skeletal muscles. Very low expression levels in lung and spleen. Colocalizes with RB1 in various tissues.
  • 数据库链接：

    KEGG: mmu:12421

    STRING: 10090.ENSMUSP00000027040

    UniGene: Mm.293811

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