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  4. Recombinant Mouse Putative Polycomb group protein ASXL2 (Asxl2), partial

Recombinant Mouse Putative Polycomb group protein ASXL2 (Asxl2), partial

  • 中文名称：
    Recombinant Mouse Putative Polycomb group protein ASXL2(Asxl2) ,partial
  • 货号：
    CSB-YP807436MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Putative Polycomb group protein ASXL2(Asxl2) ,partial
  • 货号：
    CSB-EP807436MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Putative Polycomb group protein ASXL2(Asxl2) ,partial
  • 货号：
    CSB-EP807436MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Putative Polycomb group protein ASXL2(Asxl2) ,partial
  • 货号：
    CSB-BP807436MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Putative Polycomb group protein ASXL2(Asxl2) ,partial
  • 货号：
    CSB-MP807436MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Asxl2
  • Uniprot No.：
    Q8BZ32
  • 别名：
    Asxl2; Kiaa1685Putative Polycomb group protein ASXL2; Additional sex combs-like protein 2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility. Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator for PPARG and enhances its adipocyte differentiation-inducing activity; the function seems to involve differential recruitment of acetylated and methylated histone H3.
  • 基因功能参考文献：
    1. ASXL2 functions as a tumour suppressor to maintain normal Hematopoietic stem cell function. PMID: 28593990
    2. ASXL2 is essential for haematopoiesis and acts as a haploinsufficient tumour suppressor in leukemia. PMID: 28516957
    3. ASXL2 is a master regulator of skeletal, lipid, and glucose homeostasis PMID: 26051940
    4. Asxl2-/- neonates have patent ductus arteriosus and consequent lung hemorrhage and die soon after birth. PMID: 24860998
    5. ASXL2 and WTIP are expressed in mouse embryonic epicardial cells. ASXL2 and WTIP participate in regulation of retinoic acid signaling during heart development. PMID: 25065743
    6. ASXL2 and PRC2 interact in the adult heart and co-localize to target promoters. PMID: 24040135
    7. Chromatin factors like Asxl2 function in the adult heart to regulate cell type- and stage-specific patterns of gene expression. PMID: 23046516
    8. the knockdown of Asxl2 in bone marrow macrophages impaired their ability to form osteoclasts. PMID: 21490954

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Asx family
  • 数据库链接：

    KEGG: mmu:75302

    STRING: 10090.ENSMUSP00000106846

    UniGene: Mm.120475

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