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  4. Recombinant Mouse Putative ATP-dependent Clp protease proteolytic subunit, mitochondrial (Clpp)

Recombinant Mouse Putative ATP-dependent Clp protease proteolytic subunit, mitochondrial (Clpp)

  • 中文名称：
    Recombinant Mouse Putative ATP-dependent Clp protease proteolytic subunit, mitochondrial(Clpp)
  • 货号：
    CSB-YP005577MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Putative ATP-dependent Clp protease proteolytic subunit, mitochondrial(Clpp)
  • 货号：
    CSB-EP005577MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Putative ATP-dependent Clp protease proteolytic subunit, mitochondrial(Clpp)
  • 货号：
    CSB-EP005577MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Putative ATP-dependent Clp protease proteolytic subunit, mitochondrial(Clpp)
  • 货号：
    CSB-BP005577MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Putative ATP-dependent Clp protease proteolytic subunit, mitochondrial(Clpp)
  • 货号：
    CSB-MP005577MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Clpp
  • Uniprot No.：
    O88696
  • 别名：
    ClppATP-dependent Clp protease proteolytic subunit; mitochondrial; EC 3.4.21.92; Endopeptidase Clp
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    53-272
  • 氨基酸序列
    PLIPIVVE QTGRGERAYD IYSRLLRERI VCVMGPIDDS VASLVIAQLL FLQSESNKKP IHMYINSPGG VVTAGLAIYD TMQYILNPIC TWCVGQAASM GSLLLAAGSP GMRHSLPNSR IMIHQPSGGA RGQATDIAIQ AEEIMKLKKQ LYNIYAKHTK QSLQVIESAM ERDRYMSPME AQEFGILDKV LVHPPQDGED EPELVQKETA TAPTDPPAPT ST
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Protease component of the Clp complex that cleaves peptides and various proteins in an ATP-dependent process. Has low peptidase activity in the absence of CLPX. The Clp complex can degrade CSN1S1, CSN2 and CSN3, as well as synthetic peptides (in vitro) and may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates. Cleaves PINK1 in the mitochondrion.
  • 基因功能参考文献：
    1. we demonstrate that a strong mitochondrial cardiomyopathy and diminished respiration due to DARS2 deficiency can be alleviated by the loss of CLPP, leading to an increased de novo synthesis of individual OXPHOS subunits. PMID: 27154400
    2. The authors present evidence that mammalian CLPP has an essential role in determining the rate of mitochondrial protein synthesis by regulating the level of mitoribosome assembly. PMID: 27797820
    3. Novel effects of ClpP on mitochondrial morphology, cell proliferation and protein translation pathways in muscle cells. PMID: 26721594
    4. Loss of mitochondrial peptidase Clpp leads to infertility, hearing loss plus growth retardation via accumulation of CLPX, mtDNA and inflammatory factors. PMID: 23851121
    5. The correlative effect of Lon and ClpP upregulation on loss of mitochondrial Fe-S proteins during the progression of the disease may suggest that Fe-S proteins are potential targets of Lon and ClpP proteases in FRDA. PMID: 19154341

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  • 亚细胞定位：
    Mitochondrion matrix.
  • 蛋白家族：
    Peptidase S14 family
  • 组织特异性：
    Detected in liver (at protein level). High levels found in heart, liver and skeletal muscle.
  • 数据库链接：

    KEGG: mmu:53895

    STRING: 10090.ENSMUSP00000002735

    UniGene: Mm.287892

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