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  4. Recombinant Mouse Protein phosphatase 1 regulatory subunit 3A (Ppp1r3a), partial

Recombinant Mouse Protein phosphatase 1 regulatory subunit 3A (Ppp1r3a), partial

  • 中文名称：
    小鼠Ppp1r3a重组蛋白
  • 货号：
    CSB-YP859153MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Ppp1r3a重组蛋白
  • 货号：
    CSB-EP859153MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Ppp1r3a重组蛋白
  • 货号：
    CSB-EP859153MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Ppp1r3a重组蛋白
  • 货号：
    CSB-BP859153MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Ppp1r3a重组蛋白
  • 货号：
    CSB-MP859153MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Ppp1r3a
  • Uniprot No.：
    Q99MR9
  • 别名：
    Ppp1r3a; Pp1g; Protein phosphatase 1 regulatory subunit 3A; Protein phosphatase 1 glycogen-associated regulatory subunit; Protein phosphatase type-1 glycogen targeting subunit; RG1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Plays an important role in glycogen synthesis but is not essential for insulin activation of glycogen synthase.
  • 基因功能参考文献：
    1. results show that dysfunction of subunit PPP1R3A of protein phosphatase 1 leads to weight gain, increased fat deposition and insulin resistance PMID: 12606498
    2. Mice in which human PPP1R3A C1984DeltaAG replaced mouse PP1R3A had decreased muscle glycogen levels because failure of the truncated mutant to bind glycogen & colocalize with glycogen synthase (GS) decreased GS & increased glycogen phosphorylase activity. PMID: 18232732
    3. Backcrossing of G(M)-/- mice onto two different genetic backgrounds gave rise to lean, glucose-tolerant, insulin-sensitive G(M)-/- mice indicating that at least one variant gene,is required for the development of the prediabetic phenotype of obese mice. PMID: 18234908
    4. Disruption of the Ppp1r3a gene does not result in either fat deposition or insulin resistance, but PPP1r3a is essential for control of glycogen metabolism by exercise. PMID: 11283248
  • 亚细胞定位：
    Membrane; Single-pass membrane protein.
  • 组织特异性：
    Skeletal muscle and heart.
  • 数据库链接：

    KEGG: mmu:140491

    STRING: 10090.ENSMUSP00000049054

    UniGene: Mm.209429

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