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  4. Recombinant Mouse Protein capicua homolog (Cic), partial

Recombinant Mouse Protein capicua homolog (Cic), partial

  • 中文名称：
    Recombinant Mouse Protein capicua homolog(Cic) ,partial
  • 货号：
    CSB-YP821666MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Protein capicua homolog(Cic) ,partial
  • 货号：
    CSB-EP821666MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Protein capicua homolog(Cic) ,partial
  • 货号：
    CSB-EP821666MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Protein capicua homolog(Cic) ,partial
  • 货号：
    CSB-BP821666MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Protein capicua homolog(Cic) ,partial
  • 货号：
    CSB-MP821666MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Cic
  • Uniprot No.：
    Q924A2
  • 别名：
    Cic; Kiaa0306Protein capicua homolog
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcriptional repressor which plays a role in development of the central nervous system (CNS). In concert with ATXN1 and ATXN1L, involved in brain development.
  • 基因功能参考文献：
    1. maintains T-cell homeostasis and negatively regulates follicular helper T cell development and autoimmunity PMID: 28855737
    2. Loss of CIC causes T cell lymphoblastic leukemia/lymphoma. PMID: 29382756
    3. Results indicate an important role for transcriptional repression factor Capicua (CIC) in regulating neural cell proliferation and lineage specification, and suggest that CIC mutations may impact the pathogenesis and therapeutic targeting of oligodendroglioma. PMID: 28939681
    4. The data shows that Cic is an essential gene in mouse development and that systemic disruption of Cic DNA binding in adult mice causes T-cell acute lymphoblastic lymphoma PMID: 28827401
    5. Our findings indicate that CIC is a critical regulator of BA homeostasis, and that its dysfunction might be associated with chronic liver disease and metabolic disorders. PMID: 25653040
    6. mechanism by which constitutive reduction of Cic rescues Spinocerebellar ataxia type 1 PMID: 22053053
    7. Severe developmental bone phenotype in Cic deficient mice is reported. PMID: 20599900
    8. Results describe the identification and characterization of a new gene, Cic, in both human and mouse genomes, that is implicated in granule cell development. PMID: 12393275

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Expressed in the cortex and hypothalamus (at protein level). Isoform 1: Present in cerebellum (at protein level). Isoform 2: Present in cerebellum (at protein level).
  • 数据库链接：

    KEGG: mmu:71722

    STRING: 10090.ENSMUSP00000005578

    UniGene: Mm.28833

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