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  4. Recombinant Mouse Protein NLRC5 (Nlrc5), partial

Recombinant Mouse Protein NLRC5 (Nlrc5), partial

  • 中文名称：
    小鼠Nlrc5重组蛋白
  • 货号：
    CSB-YP015863MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Nlrc5重组蛋白
  • 货号：
    CSB-EP015863MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Nlrc5重组蛋白
  • 货号：
    CSB-EP015863MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Nlrc5重组蛋白
  • 货号：
    CSB-BP015863MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Nlrc5重组蛋白
  • 货号：
    CSB-MP015863MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Nlrc5
  • Uniprot No.：
    C3VPR6
  • 别名：
    Nlrc5; Protein NLRC5
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Probable regulator of the NF-kappa-B and type I interferon signaling pathways. May also regulate the type II interferon signaling pathway. Plays a role in homeostatic control of innate immunity and in antiviral defense mechanisms.
  • 基因功能参考文献：
    1. Taken together, NLRC5 promotes inflammation and fibrosis during diabetic nephropathy progression partly through the effects on NF-kappaB and TGF-beta/Smad pathways. PMID: 29070585
    2. NLRC5 knockout mice fed with high fat showed accelerated fibrosis and inflammation response by promoting alpha-SMA, Collagen I, Collagen III, TLR4/MyD88, phosphorylated IKKalpha, IkappaBalpha and NF-kappaB expression. PMID: 28499247
    3. NLRC5 knockout in mice exhibited greater hepatic injury after hepatic ischemia/reperfusion (I/R) injury. PMID: 28784305
    4. The observed increases in viral titers in NLRC5-deficient mice correlated with impaired effector CD8(+) T cell responses. Although NLRC5-deficient mice were defective at clearing the virus, they did not show an increase in morbidity or mortality following influenza virus infection because of other compensatory immune mechanisms. PMID: 28615208
    5. NLRC5 regulates TGFB1-induced proliferation and activation of hepatic stellate cells during hepatic fibrosis. PMID: 26592197
    6. NLRC5 is differentially expressed in hepatic tissues and hepatic stellate cells during hepatic fibrosis and its reversal PMID: 26806094
    7. NLRC5 expression in T cells is required to protect them from NK-cell-mediated elimination upon inflammation. PMID: 26861112
    8. NLRC5 and CIITA thus emerge as paradigms for a novel class of transcriptional regulators dedicated for transactivating extremely few, phylogenetically related genes. PMID: 25811463
    9. Unusual structural features revealed by the solution NMR structure of the NLRC5 caspase recruitment domain. PMID: 24815518
    10. Data conclude that Nlrc5 is important in the regulation of MHC-I expression by reducing H3K27me3 on MHC-I promoter and joins CIITA as an NLR subfamily that controls MHC gene transcription. PMID: 22645137
    11. NLRC5 is required for both constitutive and inducible histocompatibility class I gene expression and host defense. PMID: 22711889
    12. NLRC5 ablation reduces MHC class I expression, and enhances IKK and IRF3 phosphorylation in response to TLR stimulation or viral infection. PMID: 22473004
    13. NLRC5-deficient mice showed a profound defect in the expression of MHC class I genes and a concomitant failure to activate L. monocytogenes-specific CD8(+) T cell responses, including activation, proliferation and cytotoxicity. PMID: 22491475
    14. NLRC5 overexpression promotes interleukin (IL)-1beta production via caspase-1 and is dispensable for cytokine induction in virus and bacterial infections under physiologic conditions. PMID: 21148033
    15. NLRC5 expression is critical for lipopolysaccharide-induced interleukin (IL)-10 production in RAW264.7 macrophages. PMID: 20610642
    16. Study identifies NLRC5 as a negative regulator that blocks two central components of the NF-kappaB and type I interferon signaling pathways and suggest an important role for NLRC5 in homeostatic control of innate immunity. PMID: 20434986

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    NLRP family
  • 组织特异性：
    Expressed in spleen, thymus and lung.
  • 数据库链接：

    KEGG: mmu:434341

    UniGene: Mm.334720

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