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  4. Recombinant Mouse Protein LAP2 (Erbb2ip), partial

Recombinant Mouse Protein LAP2 (Erbb2ip), partial

  • 中文名称：
    小鼠Erbin重组蛋白
  • 货号：
    CSB-YP770455MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Erbin重组蛋白
  • 货号：
    CSB-EP770455MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Erbin重组蛋白
  • 货号：
    CSB-EP770455MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Erbin重组蛋白
  • 货号：
    CSB-BP770455MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Erbin重组蛋白
  • 货号：
    CSB-MP770455MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Erbin
  • Uniprot No.：
    Q80TH2
  • 别名：
    Erbin; Erbb2ip; Kiaa1225; Lap2Erbin; Densin-180-like protein; Erbb2-interacting protein; Protein LAP2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated ERBB2 'Tyr-1248' receptor, it may contribute to stabilize this unphosphorylated state. Inhibits NOD2-dependent NF-kappa-B signaling and proinflammatory cytokine secretion.
  • 基因功能参考文献：
    1. Overexpression of FHL2 alone had no effect on Erbin expression, but in the presence of MITF, Erbin expression was decreased. PMID: 26025865
    2. By degrading Erbin and Nrf2, Sag activates the Ras-Raf pathway and causes ROS accumulation to trigger autophagy and senescence PMID: 26056141
    3. Erbin promotes tumourigenesis and tumour growth in colorectal cancer by stabilizing epidermal growth factor receptor PMID: 25521828
    4. Results support that hyperglycemia may impair NRG1/Erb B2 signaling by disrupting the balance between NRG1 isoforms, decreasing the expression of erbin and correspondingly activating the MAPK pathway PMID: 24252174
    5. Erbin is an inhibitor of pathological cardiac hypertrophy. PMID: 24711380
    6. These observations demonstrate a crucial function for Erbin in AMPAR surface expression in cortical parvalbumin positive interneurons PMID: 23354328
    7. This study demonistrated that demonstrate that Erbin is required for remyelination of regenerated axons after injury, probably by regulating ErbB2 and NRG1 levels, identifying a novel player in regulating remyelination. PMID: 23100438
    8. preliminary characterization of its interaction with Smad3 PMID: 12650946
    9. erbin regulates MAP kinase activation in Schwann cells and suggest that erbin links merlin to both adherens junction protein complexes and the MAP kinase signaling pathway. PMID: 15659388
    10. Erbin is a regulator of Nod2-dependent NF-kappaB signaling with a role in inflammatory responses PMID: 16203728
    11. These observations indicate a critical role of Erbin in myelination and identify a regulatory mechanism of NRG1 signaling. PMID: 19458253

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  • 亚细胞定位：
    Cell junction, hemidesmosome. Nucleus membrane. Basolateral cell membrane.
  • 蛋白家族：
    LAP (LRR and PDZ) protein family
  • 数据库链接：

    KEGG: mmu:59079

    STRING: 10090.ENSMUSP00000057956

    UniGene: Mm.277354

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