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  4. Recombinant Mouse Protein Jumonji (Jarid2), partial

Recombinant Mouse Protein Jumonji (Jarid2), partial

  • 中文名称：
    小鼠Jarid2重组蛋白
  • 货号：
    CSB-YP733821MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Jarid2重组蛋白
  • 货号：
    CSB-EP733821MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Jarid2重组蛋白
  • 货号：
    CSB-EP733821MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Jarid2重组蛋白
  • 货号：
    CSB-BP733821MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Jarid2重组蛋白
  • 货号：
    CSB-MP733821MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Jarid2
  • Uniprot No.：
    Q62315
  • 别名：
    Jarid2; Jmj; Protein Jumonji; Jumonji/ARID domain-containing protein 2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. Acts as an accessory subunit for the core PRC2 (Polycomb repressive complex 2) complex, which mediates histone H3K27 (H3K27me3) trimethylation on chromatin. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells, thereby playing a key role in stem cell differentiation and normal embryonic development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases. Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5. Participates in the negative regulation of cell proliferation signaling. Does not have histone demethylase activity.
  • 基因功能参考文献：
    1. JARID2 regulates muscle differentiation by modulating Wnt signaling through direct repression of SFRP1. PMID: 30119689
    2. These findings ascribe a critical function to Jarid2 and define a key mechanism that links PRC1 and PRC2 in the establishment of Polycomb domains. PMID: 27892467
    3. findings demonstrate a critical role for Etv2-miR-130a-Jarid2 in vascular patterning both in vitro and in vivo PMID: 29232705
    4. study suggests that miR-155 plays a host-damaging role during dextran sulfate sodium-induced colitis mice and induces Th17 differentiation by targeting Jarid2 PMID: 28461115
    5. JARID2 physically interacts with ESRRB, SALL4A, and PRDM14 PMID: 26523946
    6. ESCs lacking Jarid2 show constitutive Nanog expression, reduced PCP/Wnt signaling and form more than one ICM upon injection to E3.5 mouse blastocysts. PMID: 26190104
    7. Jarid2 is a novel player in iNKT cell maturation that regulates PLZF expression by modulating H3K9 methylation PMID: 25105474
    8. Jarid2 is an important component of PRC2 that has a central role in coordinating hematopoietic stem and progenitor cell function PMID: 25645357
    9. miR-155 regulates the fate of Th17 and Treg cells and miR-155 contributes to Th17 cell function by suppressing the inhibitory effects of Jarid2. PMID: 24856900
    10. Data indicate that upon stimulation of muscle cells with IFN-gamma, JARID2 and other members of the Polycomb repressive complex 2 (PRC2) were recruited to promoters to repress myogenesis. PMID: 24327761
    11. Jarid2 exhibits nucleosome-binding activity that contributes to PRC2 stimulation PMID: 24352422
    12. Jarid2 (Jumonji, AT rich interactive domain 2) regulates NOTCH1 expression via histone modification in the developing heart. PMID: 22110129
    13. these studies identify JARID2, MTF2, and esPRC2p48 as important regulatory subunits of PRC2 in ES cells and reveal critical functions of these subunits PMID: 21732481
    14. Jarid2 is required for the scheduled proliferation of epidermal stem and progenitor cells necessary to maintain epidermal homeostasis. PMID: 21811233
    15. Endothelial Jarid2/Jumonji is required for normal cardiac development and proper Notch1 expression PMID: 21402699
    16. A Jmj-cyclin D1 pathway coordinately regulates proliferation and differentiation of cardiomyocytes. PMID: 21447557
    17. Jarid2 (a specific regulatory subunit of the Polycomb repressive complex 2) regulates function at bivalent genes in embryonic stem cells. (Review) PMID: 21213100
    18. Data from family-based linkage disequilibrium study confirmed the pivotal role of JARID2 in orofacial development and strongly supports a role for this gene in CL/P etiology. PMID: 20506229
    19. Findings highlight Jarid2 as one of several potential mediators of the critical role played by Nkx2.5 during OFT morphogenesis. PMID: 20549724
    20. Jarid2 associates with Polycomb-Repressive Complex 2 and stimulates its enzymatic activity in vitro PMID: 20123894
    21. Jarid2 promotes PRC2 recruitment to the target genes while inhibiting PRC2 histone methyltransferase activity, suggesting that it acts as a "molecular rheostat" that finely calibrates PRC2 functions at developmental genes. PMID: 20064375
    22. Study demonstrates that JMJ is a subunit of the PRC2 complex, colocalizes with PRC2 on chromatin, and regulates H3K27me3 modification by modulating PRC2 activity. PMID: 20064376
    23. Jml downregulates cardiac cell proliferation by repressing cyclin D1 expression. PMID: 12852854
    24. domains for transcriptional repression, DNA binding, and nuclear localization signal were mapped PMID: 12890668
    25. jumonji mutant mice have cardiac abnormalities and early lethality. PMID: 15504358
    26. Jumonji may play important roles in the down-regulation of ANF gene expression and in heart development PMID: 15542826
    27. JMJ has a role in cardiovascular development in mice [review] PMID: 15580614
    28. data suggest that jumonji down-regulates the cell growth via interaction with retinblastoma protein, which would provide important insights into the cardiac defects observed in jmj mutant mice PMID: 15870077
    29. jmj is mainly expressed in the cyclin D1 negative region in the hindbrain, and cyclin D1 expression in the ventricular zone was upregulated in jmj mutants. PMID: 17189626
    30. data suggest that JMJ may be a critical, previously unrecognized factor that mediates some of the cellular effects of NO (nitric oxide), that NO may be able to increase JMJ in diseases associated with reduced JMJ expression PMID: 18498724

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  • 亚细胞定位：
    Nucleus. Note=Colocalizes with the PRC2 complex on chromatin.
  • 蛋白家族：
    JARID2 family
  • 组织特异性：
    Widely expressed in embryos. In adults, expressed at high levels in heart, skeletal muscle, brain and thymus.
  • 数据库链接：

    KEGG: mmu:16468

    STRING: 10090.ENSMUSP00000037774

    UniGene: Mm.25059

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