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  4. Recombinant Mouse Protein CIP2A (Kiaa1524), partial

Recombinant Mouse Protein CIP2A (Kiaa1524), partial

  • 中文名称：
    Recombinant Mouse Protein CIP2A(Kiaa1524) ,partial
  • 货号：
    CSB-YP804874MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Protein CIP2A(Kiaa1524) ,partial
  • 货号：
    CSB-EP804874MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Protein CIP2A(Kiaa1524) ,partial
  • 货号：
    CSB-EP804874MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Protein CIP2A(Kiaa1524) ,partial
  • 货号：
    CSB-BP804874MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Protein CIP2A(Kiaa1524) ,partial
  • 货号：
    CSB-MP804874MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Cip2a
  • Uniprot No.：
    Q8BWY9
  • 别名：
    Cip2a; Kiaa1524Protein CIP2A; Cancerous inhibitor of PP2A; p90 autoantigen homolog
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Promotes anchorage-independent cell growth and tumor formation.
  • 基因功能参考文献：
    1. Knockdown of CIP2A by stable CIP2A siRNA transfection inhibited MDA-MB-231 cell proliferation, invasion, colony growth in vitro, and xenograft growth and metastasis in vivo of breast cancer in mice. PMID: 26813457
    2. CIP2A as a hitherto unrecognized mediator of T-cell activation. PMID: 27100879
    3. Downregulation of CIP2A suppresses cell proliferation and growth of nasopharyngeal carcinoma. PMID: 24884612
    4. CIP2A strongly interacts with NEK2 during G2/M phase, thereby enhancing NEK2 kinase activity to facilitate centrosome separation in a PP1- and PP2A-independent manner. PMID: 24214971
    5. Data show that CIP2A expression can be systematically inhibited without severe consequences to normal mouse development and viability may have clinical relevance regarding targeting of oncogenic CIP2A for future cancer therapies. PMID: 22461891
    6. Loss of CIP2A in Myc-overexpressing neural progenitor cells significantly reduces the ability of Myc to increase self-renewal and proliferation. PMID: 20447748

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  • 亚细胞定位：
    Membrane; Single-pass membrane protein. Cytoplasm.
  • 组织特异性：
    Highly expressed in E17.5 and E18.5 liver but not pexpressed in adult liver. Expressed at moderate level in embryonic brain, muscle and epidermal layers.
  • 数据库链接：

    KEGG: mmu:224171

    STRING: 10090.ENSMUSP00000044714

    UniGene: Mm.24491

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