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  4. Recombinant Mouse Programmed cell death 6-interacting protein (Pdcd6ip), partial

Recombinant Mouse Programmed cell death 6-interacting protein (Pdcd6ip), partial

  • 中文名称：
    小鼠Pdcd6ip重组蛋白
  • 货号：
    CSB-YP893885MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Pdcd6ip重组蛋白
  • 货号：
    CSB-EP893885MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Pdcd6ip重组蛋白
  • 货号：
    CSB-EP893885MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Pdcd6ip重组蛋白
  • 货号：
    CSB-BP893885MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Pdcd6ip重组蛋白
  • 货号：
    CSB-MP893885MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Pdcd6ip
  • Uniprot No.：
    Q9WU78
  • 别名：
    Pdcd6ip; Aip1; AlixProgrammed cell death 6-interacting protein; ALG-2-interacting protein 1; ALG-2-interacting protein X; E2F1-inducible protein; Eig2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Multifunctional protein involved in endocytosis, multivesicular body biogenesis, membrane repair, cytokinesis, apoptosis and maintenance of tight junction integrity. Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway requires the sequential function of ESCRT-O, -I,-II and -III complexes. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. Adapter for a subset of ESCRT-III proteins, such as CHMP4, to function at distinct membranes. Required for completion of cytokinesis. May play a role in the regulation of both apoptosis and cell proliferation. Regulates exosome biogenesis in concert with SDC1/4 and SDCBP. By interacting with F-actin, PARD3 and TJP1 secures the proper assembly and positioning of actomyosin-tight junction complex at the apical sides of adjacent epithelial cells that defines a spatial membrane domain essential for the maintenance of epithelial cell polarity and barrier.
  • 基因功能参考文献：
    1. Alix-dependent, clathrin independent endocytosis is essential for controlling brain size. PMID: 28322231
    2. By interacting with F-actin, the Par complex and ZO-1, Alix ensures the formation and maintenance of the apically restricted actomyosin-tight junction complex. PMID: 27336173
    3. Alix acts in concert with endophilin A to promote clathrin-independent endocytosis of cholera toxin and to regulate cell migration. PMID: 27244115
    4. ATG12-ATG3 interacts with Alix to promote basal autophagic flux and late endosome function. PMID: 25686249
    5. We have provided evidence that a promigratory function of galectin-3 may be mediated through interaction with its binding partner Alix. PMID: 22785133
    6. Identify key role for syndecan-syntenin-ALIX in membrane transport and signalling processes. PMID: 22660413
    7. the Ozz-E3 ligase regulates Alix at sites where the actin cytoskeleton undergoes remodeling. PMID: 22334701
    8. Alix is a crucial mediator of Ca(2+) induced caspase 9 activation. PMID: 20471954
    9. Biochemical characterization of two analogues of the apoptosis-linked gene 2 protein in Dictyostelium discoideum and interaction with murine Alix. PMID: 11927596
    10. overexpression of Alix-CT leads to cytoplasmic vacuolization into tubulo-vesicular structures PMID: 12034747
    11. interaction of Gag with Tsg101 and Alix favors budding from the plasma membrane and relieves a requirement for ubiquitination by Nedd4 PMID: 15908698
    12. tTe interaction of the ALG-2/Alix complex with TSG101 & CHMP4b is necessary for naturally occurring death of motoneurons. Alix represents a molecular link between the endolysosomal system and the cell death machinery. PMID: 16407552
    13. These results eliminate the possibility that the two transcript variants encode different isoforms of Alix protein and suggest that alternative polyadenylation is one of the mechanisms controlling Alix protein expression. PMID: 17673164
    14. a sub-population of Alix localizes extracellularly and regulates integrin-mediated cell adhesions and fibronectin matrix assembly. PMID: 18636094
    15. E. faecalis strain-specific induction of colitis in IL-10-/- mice after 14 weeks of monoassociation. Our study suggests that Alix/AIP1 protein expression and ERK1/2 activation are decreased in severe colitis. PMID: 19166300

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  • 亚细胞定位：
    Cytoplasm, cytosol. Melanosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Secreted, extracellular exosome. Cell junction, tight junction. Midbody, Midbody ring.
  • 组织特异性：
    Ubiquitously expressed. High expression in choroid plexus and low expression in cerebral cortex (at protein level).
  • 数据库链接：

    KEGG: mmu:18571

    STRING: 10090.ENSMUSP00000107492

    UniGene: Mm.29816

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