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  4. Recombinant Mouse Probable ubiquitin carboxyl-terminal hydrolase FAF-X (Usp9x), partial

Recombinant Mouse Probable ubiquitin carboxyl-terminal hydrolase FAF-X (Usp9x), partial

  • 中文名称：
    小鼠Usp9x重组蛋白
  • 货号：
    CSB-YP025754MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Usp9x重组蛋白
  • 货号：
    CSB-EP025754MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Usp9x重组蛋白
  • 货号：
    CSB-EP025754MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Usp9x重组蛋白
  • 货号：
    CSB-BP025754MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Usp9x重组蛋白
  • 货号：
    CSB-MP025754MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Usp9x
  • Uniprot No.：
    P70398
  • 别名：
    Usp9x; Fafl; Fam; Probable ubiquitin carboxyl-terminal hydrolase FAF-X; EC 3.4.19.12; Deubiquitinating enzyme FAF-X; Fat facets homolog; Fat facets protein-related; X-linked; Ubiquitin carboxyl-terminal hydrolase FAM; Ubiquitin thioesterase FAF-X; Ubiquitin-specific protease 9; X chromosome; Ubiquitin-specific-processing protease FAF-X
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Deubiquitinase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Specifically hydrolyzes 'Lys-48'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitins chains. Essential component of TGF-beta/BMP signaling cascade. Specifically deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Deubiquitinates alkylation repair enzyme ALKBH3. OTUD4 recruits USP7 and USP9X to stabilize ALKBH3, thereby promoting the repair of alkylated DNA lesions. Regulates chromosome alignment and segregation in mitosis by regulating the localization of BIRC5/survivin to mitotic centromeres. Involved in axonal growth and neuronal cell migration. Regulates cellular clock function by enhancing the protein stability and transcriptional activity of the core circadian protein ARNTL/BMAL1 via its deubiquitinating activity.
  • 基因功能参考文献：
    1. Study shows that USP9X deubiquitylating enzyme maintains RAPTOR protein levels, mTORC1 signalling and proliferation in neural progenitors. USP9X is the first deubiquitylating enzyme shown to stabilize RAPTOR. PMID: 28341829
    2. Report crucial role of the spermatogonial USP9X during transition from the mitotic to meiotic phases and/or maintenance of early meiotic phase in spermatogenesis. PMID: 28559472
    3. these findings highlight the critical role played by USP9X in the normal morphological development of the postnatal dentate gyrus. PMID: 27181636
    4. these data suggest that TCR-mediated signals enhance Themis stability upon T cell development and identify USP9X as a key regulator of Themis protein turnover PMID: 28877990
    5. In B lymphocytes, Usp9X is required for the induction of PKCbeta kinase activity after B-Cell Antigen Receptor-dependent activation. PMID: 26936881
    6. Usp9X is a positive regulator of proximal TCR signaling in peripheral T cells and also contributes to T cell tolerance established during intrathymic development. PMID: 25200027
    7. we identified USP9X as a potential therapeutic target in prostate cancer cells and established WP1130 as a lead compound for the development of ERG-depleting drugs. PMID: 24591637
    8. Loss of Usp9x disrupts cortical architecture, hippocampal development and TGFbeta-mediated axonogenesis. PMID: 23861879
    9. USP9X is a crucial positive regulator of the T Cell Receptor signaling pathway and is required for T-cell function through the modulation of Carma1-Bcl10-Malt1 complex formation. PMID: 23690623
    10. the deubiquitinase USP9X as a novel mTORC1 and -2 binding partner that negatively regulates mTOR activity and skeletal muscle differentiation. PMID: 22544753
    11. loss of Usp9x enhances transformation and protects pancreatic cancer cells from anoikis PMID: 22699621
    12. Zymophagy, a novel selective autophagy pathway mediated by VMP1-USP9x-p62, prevents pancreatic cell death. PMID: 21173155
    13. Expressed in both germ cell and supporting cell lineages during mouse gonadal development in stage- and sex-dependent manners. PMID: 12617843
    14. Usp9x is significantly higher in the adult female mouse brains than in male brains. This implies that the difference in sex chromosome complement between XY males and XX females could potentially contribute to sexual differentiation of brain structure. PMID: 15978012
    15. Age-associated changes in DNA methylation and ubiquitin system protein concentrations potentially contribute to developmental changes in brain structure and function. PMID: 16023255
    16. USP9X-induced polarization of neural progenitors results in their radial arrangement, which provides an environment conducive for self-renewal. PMID: 19176755

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  • 亚细胞定位：
    Cytoplasm. Cell projection, growth cone.
  • 蛋白家族：
    Peptidase C19 family
  • 组织特异性：
    Ubiquitously expressed in adult tissues.
  • 数据库链接：

    KEGG: mmu:22284

    STRING: 10090.ENSMUSP00000086716

    UniGene: Mm.242646

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