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  4. Recombinant Mouse Probable phospholipid-transporting ATPase IB (Atp8a2), partial

Recombinant Mouse Probable phospholipid-transporting ATPase IB (Atp8a2), partial

  • 中文名称：
    Recombinant Mouse Probable phospholipid-transporting ATPase IB(Atp8a2) ,partial
  • 货号：
    CSB-YP002417MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Probable phospholipid-transporting ATPase IB(Atp8a2) ,partial
  • 货号：
    CSB-EP002417MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Probable phospholipid-transporting ATPase IB(Atp8a2) ,partial
  • 货号：
    CSB-EP002417MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Probable phospholipid-transporting ATPase IB(Atp8a2) ,partial
  • 货号：
    CSB-BP002417MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Probable phospholipid-transporting ATPase IB(Atp8a2) ,partial
  • 货号：
    CSB-MP002417MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Atp8a2
  • Uniprot No.：
    P98200
  • 别名：
    Atp8a2Phospholipid-transporting ATPase IB; EC 7.6.2.1; ATPase class I type 8A member 2; P4-ATPase flippase complex alpha subunit ATP8A2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. Reconstituted to liposomes, the ATP8A2:TMEM30A flippase complex predominantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE). Phospholipid translocation is not associated with a countertransport of an inorganic ion or other charged substrate from the cytoplasmic side toward the exoplasm in connection with the phosphorylation from ATP. ATP8A2:TMEM30A may be involved in regulation of neurite outgrowth. Proposed to function in the generation and maintenance of phospholipid asymmetry in photoreceptor disk membranes and neuronal axon membranes. May be involved in vesicle trafficking in neuronal cells. Required for normal visual and auditory function; involved in photoreceptor and inner ear spiral ganglion cell survival.
  • 基因功能参考文献：
    1. ATP8A2 plays a crucial role in photoreceptor and spiral ganglion cell function and survival by maintaining phospholipid composition and contributing to vesicle trafficking. PMID: 24413176
    2. Mutation of a mammalian phosphatidylserine translocase causes axon degeneration and neurodegenerative disease. PMID: 22912588
    3. P4-ATPase Atp8a2 is a phosphatidylserine flippase in photoreceptor disc membranes PMID: 19778899
  • 相关疾病：
    Defects in Atp8a2 are the cause of Wabbler-lethal (wl) phenotype. Homozygotes show severe neurological annormalities that include ataxia and body tremors linked to progressive axonal degeneration in several areas of the nervous system.
  • 亚细胞定位：
    Membrane; Multi-pass membrane protein. Golgi apparatus. Endosome. Cell projection, cilium, photoreceptor outer segment. Photoreceptor inner segment. Cell membrane. Note=Localizes to the Golgi and endosomes in photoreceptor cells. Localizes to disk membranes of rod photoreceptor outer segments (ROS).
  • 蛋白家族：
    Cation transport ATPase (P-type) (TC 3.A.3) family, Type IV subfamily
  • 组织特异性：
    Found in testis, heart and brain. Most abundant in testis. Also detected in fetal tissues. Expressed in retinal photoreceptor cells; detected in retina outer nuclear layer and inner segment (at protein level).
  • 数据库链接：

    KEGG: mmu:50769

    STRING: 10090.ENSMUSP00000079238

    UniGene: Mm.319599

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