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  4. Recombinant Mouse Probable phospholipid-transporting ATPase 11C (Atp11c), partial

Recombinant Mouse Probable phospholipid-transporting ATPase 11C (Atp11c), partial

  • 中文名称：
    Recombinant Mouse Probable phospholipid-transporting ATPase 11C(Atp11c) ,partial
  • 货号：
    CSB-YP889912MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Probable phospholipid-transporting ATPase 11C(Atp11c) ,partial
  • 货号：
    CSB-EP889912MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Probable phospholipid-transporting ATPase 11C(Atp11c) ,partial
  • 货号：
    CSB-EP889912MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Probable phospholipid-transporting ATPase 11C(Atp11c) ,partial
  • 货号：
    CSB-BP889912MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Probable phospholipid-transporting ATPase 11C(Atp11c) ,partial
  • 货号：
    CSB-MP889912MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Atp11c
  • Uniprot No.：
    Q9QZW0
  • 别名：
    Atp11cPhospholipid-transporting ATPase 11C; EC 7.6.2.1; ATPase class VI type 11C; P4-ATPase flippase complex alpha subunit ATP11C
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from the outer to the inner leaflet of the plasma membrane. Major PS-flippase in immune cell subsets. In erythrocyte plasma membrane, it is required to maintain PS in the inner leaflet preventing its exposure on the surface. This asymmetric distribution is critical for the survival of erythrocytes in circulation since externalized PS is a phagocytic signal for erythrocyte clearance by splenic macrophages. Required for B cell differentiation past the pro-B cell stage. Seems to mediate PS flipping in pro-B cells. May be involved in the transport of cholestatic bile acids.
  • 基因功能参考文献：
    1. essential for basolateral membrane localization of multiple bile salt transport proteins in central hepatocytes PMID: 26926046
    2. a mutation in ATP11C resulted in diminished flippase activity in immune cells, suggesting ATP11C is a flippase that selectively transports phosphatidylserine and phosphatidylethanolamine from the outer leaflet of the plasma membrane to the inner leaflet. PMID: 26799398
    3. an essential role for ATP11C in erythrocyte morphology and survival and provide a new candidate for the rare inherited blood disorder stomatocytosis with uncompensated anemia. PMID: 24898253
    4. Mutation of the X-linked gene Atp11c, which encodes a paralogous P4-type ATPase, precludes B-cell development in the adult bone marrow, but also causes hyperbilirubinemia. PMID: 21518881
    5. ATP11C is redundant during B cell development in the fetal liver but essential in the context of adult bone marrow where it is required for optiml responses to IL-7 and sustained expression of Ebf1. PMID: 21423172
    6. A defect is ATP11C results inlower B-cell phosphatidylserine flippase activity and disrupts B-cell development and antibody production and also causes hepatocellular carcinoma. PMID: 21423173

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  • 相关疾病：
    Mice defective in Atp11c show defective B lymphopoiesis, specifically in mature bone marrow, hyperbilirubinemia linked to mild cholestasis and hepatocellular carcinoma.
  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Cation transport ATPase (P-type) (TC 3.A.3) family, Type IV subfamily
  • 组织特异性：
    Widely expressed. Expressed in retina, brain, liver and testes (at protein level). Expressed in lung, bone marrow, lymph nodes, prostate, ovary and uterus. Expressed in fetus.
  • 数据库链接：

    KEGG: mmu:320940

    STRING: 10090.ENSMUSP00000099066

    UniGene: Mm.490394

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