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  4. Recombinant Mouse Probable JmjC domain-containing histone demethylation protein 2C (Jmjd1c), partial

Recombinant Mouse Probable JmjC domain-containing histone demethylation protein 2C (Jmjd1c), partial

  • 中文名称：
    小鼠Jmjd1c重组蛋白
  • 货号：
    CSB-YP734762MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Jmjd1c重组蛋白
  • 货号：
    CSB-EP734762MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Jmjd1c重组蛋白
  • 货号：
    CSB-EP734762MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Jmjd1c重组蛋白
  • 货号：
    CSB-BP734762MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Jmjd1c重组蛋白
  • 货号：
    CSB-MP734762MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Jmjd1c
  • Uniprot No.：
    Q69ZK6
  • 别名：
    Jmjd1c; Jhdm2c; Kiaa1380; Probable JmjC domain-containing histone demethylation protein 2C; EC 1.14.11.-; Jumonji domain-containing protein 1C
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes.
  • 基因功能参考文献：
    1. data suggest that Jmjd1c may participate in mitotic clonal expansion and the activation of the adipogenic transcription program during the induction phase of adipocyte differentiation in 3T3-L1 cells. PMID: 28501567
    2. JMJD1C ensures efficient generation and maintenance of induced pluripotent stem cells, at least partially through controlling the expression of microRNAs. PMID: 28826851
    3. These results indicate that JMJD1C has multiple functions during spermatogenesis through interactions with different partners during the spermatogenic stages PMID: 27649575
    4. JMJD1C is an important mediator of MLL-AF9- and HOXA9-driven leukemia stem cell function that is largely dispensable for hematopoietic stem cells function. PMID: 26878175
    5. Data suggest that Jmjd1c is most abundantly expressed in testis in undifferentiated spermatogonia; testes of mutant mice deficient in Jmjd1c frequently contain abnormal seminiferous tubules lacking developmentally immature germ cells. PMID: 24006281
    6. Depletion of Jmjd1c impairs growth and colony formation of MLL-AF9 cells in vitro as well as establishment of leukemia after transplantation. PMID: 24501218

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    JHDM2 histone demethylase family
  • 数据库链接：

    KEGG: mmu:108829

    STRING: 10090.ENSMUSP00000056227

    UniGene: Mm.23846

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