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  4. Recombinant Mouse Prickle-like protein 1 (Prickle1), partial

Recombinant Mouse Prickle-like protein 1 (Prickle1), partial

  • 中文名称：
    小鼠Prickle1重组蛋白
  • 货号：
    CSB-YP668861MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Prickle1重组蛋白
  • 货号：
    CSB-EP668861MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Prickle1重组蛋白
  • 货号：
    CSB-EP668861MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Prickle1重组蛋白
  • 货号：
    CSB-BP668861MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Prickle1重组蛋白
  • 货号：
    CSB-MP668861MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Prickle1
  • Uniprot No.：
    Q3U5C7
  • 别名：
    Prickle1; Prickle-like protein 1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Involved in the planar cell polarity pathway that controls convergent extension during gastrulation and neural tube closure. Convergent extension is a complex morphogenetic process during which cells elongate, move mediolaterally, and intercalate between neighboring cells, leading to convergence toward the mediolateral axis and extension along the anteroposterior axis. Necessary for nuclear localization of REST. May serve as nuclear receptor.
  • 基因功能参考文献：
    1. Prickle1 plays a role in positive regulation of differentiation and maturation of oligodendrocytes. PMID: 28935237
    2. findings argue against the role of Prickle1 in regulating hair cell polarity in the cochlea. Instead, Prickle1 regulates the polarity-related growth of distal and central processes of apical SGNs PMID: 28837644
    3. Prickle1 is part of a molecular mechanism that regulates facial branchiomotor neurons caudal migration. PMID: 24927917
    4. these findings suggest PRICKLE1 mutations contribute to ASD by disrupting the interaction with SYN1 and regulation of synaptic vesicles. PMID: 24312498
    5. Data suggest Prickle1 is part of the Wnt5a/PCP signaling, regulating cell polarity and affecting expression of multiple factors to stunt limb growth through altered patterns of gene expression, including the PCP genes Wnt5a and Vangl2. PMID: 23913870
    6. Pk1 function in axonal-dendritic development associated with the maturation of CNS neurons. PMID: 23420014
    7. Prickle1 and Prickle2 promote neurite-like process formation of C1300 cells via the Dvl1-dependent mechanism PMID: 22218901
    8. These results suggest that RILP(also known as Prickle) expression and function control REST action more so than does REST expression and is an important regulatory role in cardiomyocyte differentiation. PMID: 21199191
    9. Mutations in prickle1 causes seizures. PMID: 21276947
    10. both Prickle1 and Prickle2 promote neurite-like process formation of C1300 neuroblastoma cells via the Dishevelled dependent pathway PMID: 19788910
    11. mouse Prickle1 and Prickle2 possibly regulate positive neurite formation during brain development PMID: 17868671
    12. Results demonstrate a role for prickle1 in AB polarity formation rather than expected role as a PCP gene. PMID: 19706528

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  • 亚细胞定位：
    Nucleus membrane. Cytoplasm, cytosol.
  • 蛋白家族：
    Prickle / espinas / testin family
  • 数据库链接：

    KEGG: mmu:106042

    STRING: 10090.ENSMUSP00000049204

    UniGene: Mm.150314

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