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  4. Recombinant Mouse Potassium voltage-gated channel subfamily H member 2 (Kcnh2), partial

Recombinant Mouse Potassium voltage-gated channel subfamily H member 2 (Kcnh2), partial

  • 中文名称：
    小鼠Kcnh2重组蛋白
  • 货号：
    CSB-YP012036MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Kcnh2重组蛋白
  • 货号：
    CSB-EP012036MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Kcnh2重组蛋白
  • 货号：
    CSB-EP012036MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Kcnh2重组蛋白
  • 货号：
    CSB-BP012036MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Kcnh2重组蛋白
  • 货号：
    CSB-MP012036MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Kcnh2
  • Uniprot No.：
    O35219
  • 别名：
    Kcnh2; Erg; Merg1Potassium voltage-gated channel subfamily H member 2; Ether-a-go-go-related gene potassium channel 1; ERG-1; Eag-related protein 1; Ether-a-go-go-related protein 1; MERG; Voltage-gated potassium channel subunit Kv11.1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr).
  • 基因功能参考文献：
    1. PKD1 mediates the PKC effects on KV11.1 and we found that PKD targets S284 in the N-terminus of the channel. PMID: 29949809
    2. histone H4 hyperacetylation induced by Class I HDACs inhibitors promoted the expression profiles of potassium channels (Kcnj2, Kcnj3, Kcnj5, Kcnj11, and Kcnh2) PMID: 28464250
    3. Using a combination of mouse genetics, biochemistry, molecular and cell biology, we demonstrate that Nkx2-5 regulates the gene encoding Kcnh2 channel and others, shedding light on potential mechanisms generating electrical abnormalities observed in patients bearing NKX2-5 dysfunction and opening opportunities to the study of novel therapeutic targets for anti-arrhythmogenic therapies PMID: 26897459
    4. Report altered protein trafficking/function of mouse ERG K(+) channel clones. PMID: 25497881
    5. Enhancement of HERG protein expression through Hsp90 inhibition of CHIP binding might be a novel therapeutic strategy for long QT syndrome 2 caused by trafficking abnormalities of HERG proteins. PMID: 23963841
    6. The findings of this study suggested that MERG1a may not modulate Murf1 expression through the AKT/FOXO pathway. PMID: 23761265
    7. Data indicate presence of KCNH2 in left/right atria & indicate functional interaction between KCNH2 & KCNA5. Kinetic analyses confirm KCNH2 as "rapid" and KCNA5 as "ultra rapid" potassium channels. PMID: 20826138
    8. Knockdown of mERG1 transcripts with small interfering RNA (siRNA) dramatically reduced I (Kr) amplitude, confirming the molecular link of mERG1 and I (Kr) in HL-1 cells. PMID: 20490473
    9. The LQT2 missense mutations G601S and N470D hERG exhibited altered protein trafficking in mouse cardiomyocytes. PMID: 20363883
    10. ERG1 B is necessary for I(Kr) expression in the surface membrane of adult myocytes. Knockout of ERG1 B predisposes mice to episodic sinus bradycardia. PMID: 12612061
    11. erg1 gene expression pattern in the developing embryo. PMID: 14643686
    12. MERG1A is developmentally regulated, and it might play a role in early mouse embryogenic development. PMID: 14668215
    13. All erg genes were translated in neuronal tissue. ERG proteins were generally expressed in neuronal soma, but dendritic and/or white matter labeling could be detected in specific areas. PMID: 16127690
    14. Functional expression of the stria vascularis-specific MERG1a channel reveals a current that activates at negative potentials and shows rapid inactivation. PMID: 16177035
    15. Expression of Merg1a initiates atrophy by activating ubiquitin-proteasome proteolysis. PMID: 16723379
    16. During spinal cord development, excitability of GABAergic ventral interneurons depend on the function of the ERG current. PMID: 17251434
    17. Expression of ERG1 isoforms in the myometrium did not alter throughout gestation or upon delivery, but the expression of genes encoding auxillary subunits (KCNE) were up-regulated considerably. PMID: 19332483
    18. ERG1 K+ channels contribute to threshold excitability of mouse auditory brainstem neurons. PMID: 19359372
    19. Erg1 channels are new mediators of alpha- and beta-cell repolarization. However, antagonism of Erg1 has divergent effects in these cells; to augment glucose-dependent insulin secretion and inhibit low glucose stimulated glucagon secretion. PMID: 19690348

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Potassium channel family, H (Eag) (TC 1.A.1.20) subfamily, Kv11.1/KCNH2 sub-subfamily
  • 组织特异性：
    Isoform 1 is expressed in heart, brain and testis and at low levels in lung. Isoform 3 is expressed predominantly in heart. The expression of isoform 2 is low in all tissues tested.
  • 数据库链接：

    KEGG: mmu:16511

    STRING: 10090.ENSMUSP00000047705

    UniGene: Mm.6539

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