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  4. Recombinant Mouse Potassium voltage-gated channel subfamily H member 1 (Kcnh1), partial

Recombinant Mouse Potassium voltage-gated channel subfamily H member 1 (Kcnh1), partial

  • 中文名称：
    小鼠Kcnh1重组蛋白
  • 货号：
    CSB-YP736730MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Kcnh1重组蛋白
  • 货号：
    CSB-EP736730MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Kcnh1重组蛋白
  • 货号：
    CSB-EP736730MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Kcnh1重组蛋白
  • 货号：
    CSB-BP736730MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Kcnh1重组蛋白
  • 货号：
    CSB-MP736730MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Kcnh1
  • Uniprot No.：
    Q60603
  • 别名：
    Kcnh1; Eag; Potassium voltage-gated channel subfamily H member 1; Ether-a-go-go potassium channel 1; EAG channel 1; EAG1; m-eag; Voltage-gated potassium channel subunit Kv10.1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel. Channel properties are modulated by subunit assembly. Mediates IK(NI) current in myoblasts. Involved in the regulation of cell proliferation and differentiation, in particular adipogenic and osteogenic differentiation in bone marrow-derived mesenchymal stem cells (MSCs).
  • 基因功能参考文献：
    1. n this report, we present two independent screening campaigns in which we wanted to identify small molecules that bind to either the intracellular cytoplasmic amino terminal Per-Arnt-Sim (PAS) domain from the human EAG-related gene (ERG) channel or the amino or carboxy terminal globular domains from the mouse EAG1 channel, affecting their interaction. PMID: 26975997
    2. KV10.1 localizes to the centrosome and the primary cilium and promotes ciliary disassembly. Interference with KV10.1 ciliary localization abolishes not only the effects on ciliary disassembly, but also KV10.1-induced tumor progression in vivo Conversely. PMID: 27113750
    3. Expression of Kv10.1 driven by phosphorylated Rb/E2F1 contributes to G2/M progression of cancer and non-transformed cells. PMID: 27029528
    4. KV 10.1 opposes activity-dependent increase in calcium influx into the presynaptic terminal of the parallel fibre-Purkinje cell synapse PMID: 25556795
    5. deletion of Kv10.1 does not show a marked phenotype is a prerequisite for utilizing Kv10.1 blocking and/or reduction techniques, such as siRNA, to treat cancer. PMID: 23424202
    6. The flavonoids identified here potentiated EAG1 channels by binding to the CNBHD. PMID: 23440277
    7. 2 A resolution crystal structure of the eag domain-CNBHD complex of the mouse EAG1 (also known as KCNH1) channel PMID: 23975098
    8. Biochemical evidence was provided that suggests that there is also an unliganded conformation where the C-terminus of the domain peels away from its bound position. A role was shown for the cyclic nucleotide-homology domain in channel gating. PMID: 22732247
    9. X-ray diffraction of EAG channel data were collected to 2.2 A resolution and the crystal belonged to the hexagonal space group P3(1)21 PMID: 22442238
    10. K(V)10.1 channels at the nuclear envelope might participate in the homeostasis of nuclear K(+), or indirectly interact with heterochromatin, both factors known to affect gene expression PMID: 21559285
    11. Single crystal of EAG PAS from Mus musculus belonging to space group P3221 PMID: 20823525
    12. Ether-a-go-go-related gene K channels in interstitial cells of Cajal contribute to membrane potential and play role in regulation of pacemaker activity of small intestine. PMID: 12958021
    13. Eag1 interferes with the cellular mechanism for maintaining oxygen homeostasis, increasing HIF-1 activity, and thereby VEGF secretion and tumor vascularization PMID: 18927085
    14. Results indicate that cyclic nucleotides do not directly modulate mEAG1 and hERG1 channels. PMID: 19671703
    15. Both M-eag and its C. elegans homolog egl-2 are inhibited by the tricyclic antidepressant imipramine. PMID: 10559392

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Nucleus inner membrane; Multi-pass membrane protein. Cell projection, dendrite. Cell projection, axon. Cell junction, synapse, presynaptic cell membrane. Perikaryon. Cell junction, synapse, postsynaptic density membrane. Early endosome membrane.
  • 蛋白家族：
    Potassium channel family, H (Eag) (TC 1.A.1.20) subfamily, Kv10.1/KCNH1 sub-subfamily
  • 组织特异性：
    Detected in brain (at protein level). Highly expressed in olfactory bulb. Detected in brain cortex, hippocampus, brain stem, striatum, thalamus, hypothalamus and spinal cord.
  • 数据库链接：

    KEGG: mmu:16510

    STRING: 10090.ENSMUSP00000077563

    UniGene: Mm.4489

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