Recombinant Mouse Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Hcn1), partial

1. Study shows that hyperpolarization-activated cyclic nucleotide-gated channels reduce the rate of exocytosis from a subset of cortical synaptic terminals. PMID: 28071723
2. in Hcn1 (-/-) mice, baseline acoustic startle response (ASR)levels were lower, temporal integration was delayed, time constants for ASR depression by noise offset were higher, and their sensitivity to brief gaps and spatial acuity was diminished PMID: 28050647
3. Low-voltage-activated K(+) (gKL) and hyperpolarization-activated mixed cation conductances (gh) mediate currents, IKL and Ih, through channels of the Kv1 (KCNA) and HCN families respectively and give auditory neurons the temporal precision required for signaling information about the onset, fine structure, and time of arrival of sounds. PMID: 28065805
4. results implicate presynaptic NMDA receptor inhibition followed by reduced activity of presynaptic HCN1 channels, which would result in an increase in glutamate release and postsynaptic glutamate receptor activity, as a mechanism of ketamine action. PMID: 27965425
5. HCN channels play a critical role in the separation of overlapping movement responses and allow for successful reaching behaviours. These data provide a novel mechanism for the encoding of multiple movement responses within shared networks of motor cortex. This mechanism supports a viewpoint of primary motor cortex as a site of dynamic integration for behavioural output PMID: 27568501
6. The study thus identifies novel candidate QTGs HCN1 that may contribute to variation in emotional learning in mice. PMID: 27277803
7. Data show that prostaglandin E2 receptor EP3 subtype (EP3) was expressed in the interstitial cells of Cajal (ICCs) of the bladder and activated hyperpolarization-activated cyclic nucleotide-gated (HCN) channels. PMID: 28131828
8. Data show that KCNJ15 inward rectifier potassium channel and hyperpolarization-activated cyclic nucleotide-gated (HCN) channel currents are changed in Trisomic neuron. PMID: 26501103
9. We investigated the effects of an additional genetic deletion of HCN1 on the function and survival of photoreceptors in a mouse model of CNGB1-linked retinitis pigmentosa (RP). PMID: 26740549
10. in the absence of HCN1-mediated feedback, the amplitude of rod signals remains at high levels for a prolonged period of time, leading to saturation of the retinal pathways. PMID: 26807953
11. Resilience to tinnitus is developed in mice that show a re-emergence of KCNQ2/3 channel activity and a reduction in HCN channel activity. PMID: 26312501
12. HCN1, HCN2, and HCN4 subunits may have distinct physiological roles in the developing hippocampus. PMID: 25761792
13. Forebrain HCN1 channels contribute to hypnotic and amnestic effects of volatile anesthetics, but do not contribute to immobilizing actions. PMID: 26287296
14. This study demonstrated that Increased expression of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in reactive astrocytes following ischemia. PMID: 25042871
15. Results suggest that spike-and-wave discharges in an established model of absence epilepsy reduce hippocampal HCN1 expression and function, and that the reduction associates with a spatial learning deficit PMID: 24368169
16. Grid fields in HCN1 KO mice display more experience-dependent asymmetry consistent with reports of enhanced long-term potentiation in the absence of HCN1. The loss of HCN1 improves temporal coding via the rate-phase transformation. PMID: 24638961
17. We conclude that TRIP8b in the retina is needed to achieve maximal expression of HCN1. PMID: 24409334
18. HCN1 channels in cerebellar Purkinje cells reduce the duration of inhibitory synaptic responses. PMID: 24000178
19. acute abrogation of HCN1-FLNa interaction in neurons, with the use of decoy peptides that mimic the FLNa-binding domain of HCN1, abolishes the punctate distribution of HCN1 channels in neuronal cell bodies PMID: 24403084
20. HCN1 contributes substantially to hyperpolarization-activated current properties in individual cortical plate neurons PMID: 23821600
21. HCN1 stabilizes the leading pacemaker region within the sinoatrial node and hence is crucial for stable heart rate and regular beat-to-beat variation. HCN1-deficient mice may be a valuable genetic disease model for human sinus node disease. PMID: 24218458
22. Hcn1 ion conductivity was significantly lower in senescence-accelerated mouse prone 8 (SAMP8) compared to that of Japanese fancy mouse 1 (JF1), which may be associated with learning and memory deficiency. PMID: 24125720
23. Ther results of this study provided genetic evidence demonstrating the importance of HCN1 to intrinsic persistent firing and the behavioral output of the Prefrontal cortex. PMID: 23966682
24. These observations identify Ih as an ionic current that is regulated in a cyclical manner by circulating estradiol within the female brain PMID: 23804103
25. Data indicate that the hyperpolarization-activated cation channel HCN1 do not participate directly to the pacemaker activity of periglomerular dopaminergic neurons, but influence their resting membrane potential. PMID: 23418585
26. HCN1-containing channels represent a behaviorally relevant molecular target of ketamine. PMID: 23377220
27. Leucine zipper motif essential for gating of HCN1 and HCN2. PMID: 23048023
28. Data indicate that HCN1 and HCN2 form alternate ternary protein complexes with hair-cell stereociliary proteins. PMID: 22948144
29. Loss of KCNE2 leads to downregulation of HCN channel function associated with increased excitability in neurons in the cortico-thalamo-cortical loop. PMID: 22880098
30. Suggest that the strongly increased HCN channel activity in hypertrophied myocytes prolongs the repolarization of the ventricular action potential and thereby may increase the arrhythmogenic potential. PMID: 22652004
31. Data show that HCN1 and HCN2 channels are expressed at distinct retinal sites and serve different functions. PMID: 22279546
32. TRIP8b isoforms are important regulators of HCN1 trafficking in entorhinal neurons. PMID: 22363812
33. Data show that proper cone vision under mesopic conditions requires rapid adaptational feedback modulation of rod output via hyperpolarization-activated and cyclic nucleotide-gated channels 1. PMID: 22068599
34. blockade and activation of HCN channel activity in vitro bidirectionally altered the membrane excitability of the STN neurons. PMID: 22013231
35. Shortening and shaping of light responses by activation of HCN1 is an important step at least in the scotopic pathways. PMID: 22183410
36. HCN1 represents the isoform which is selectively expressed in most parts of the conduction system suggesting a substantial contribution of HCN1 to pacemaking. PMID: 21945247
37. Although the dorsal-ventral gradient of the grid pattern was preserved in HCN1 knockout mice, the size and spacing of the grid fields, as well as the period of the accompanying theta modulation, was expanded at all dorsal-ventral levels. PMID: 22100643
38. The results of this study suggested that that HCN1 contributes to vestibular hair cell function and the sense of balance. PMID: 22090507
39. HCN1 is strongly expressed in neurons and in entorhinal cortex grid cells, which provide spatial information to the CA1 and CA3 regions of the hippocampus. PMID: 22099465
40. we demonstrate in vivo and in vitro that the interplay of a negative chloride reversal potential, a strong inhibition and a powerful IH results in a temporally precise, duration-sensitive offset response in the superior paraolivary nucleus. PMID: 21903083
41. increasing cAMP levels in cells antagonized the up-regulation of HCN1 channels mediated by a TRIP8b construct binding the CNBD exclusively. PMID: 21504900
42. hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channel function was reduced in MitoPark DA neurons, although HCN messenger RNA was unchanged. PMID: 21233488
43. HCN1 channel inhibits glutamate synaptic release by suppressing the activity of low-threshold voltage-gated T-type Cav3.2 calcium channel signaling. PMID: 21358644
44. This study suggested that the outgrowth and coalescence of olfactory sensory neurons axons is, at least in part, subject to activity-dependent mechanisms mediated via HCN channels. PMID: 21147989
45. Down-regulation of HCN1 associated with rodent models of epilepsy may be a contributing factor in seizure behavior. PMID: 20384728
46. The differences in evolution and fucntion of HCN1 and HCN2 are reported. PMID: 20130205
47. The expression pattern of HCN isoforms in the olfactory bulb of mice, is described. PMID: 20140458
48. This study indicated that upregulation of alpha5 subunit-mediated GABA(A) receptor tonic current compensates quantitatively for loss of dendritic I(h) in cortical pyramidal neurons from HCN1 knock-out mice to maintain normal synaptic summation. PMID: 20164346
49. determination that S5-P Cys(318) of HCN1 is externally accessible and that the external pore vestibule and activation gating of HCN channels are allosterically coupled PMID: 12351622
50. Major contributions of HCN1 and HCN2 channel isoforms to hyperpolarization-activated, non-selective cation current. HL-1 cells display a hyperpolarization-activated current which might contribute to spontaneous contractile activity of these cells. PMID: 12433951

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KEGG: mmu:15165

STRING: 10090.ENSMUSP00000006991

UniGene: Mm.343429