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  4. Recombinant Mouse Plasminogen activator inhibitor 2, macrophage（Serpinb2)

Recombinant Mouse Plasminogen activator inhibitor 2, macrophage（Serpinb2)

  • 中文名称：
    Recombinant Mouse Plasminogen activator inhibitor 2, macrophage（Serpinb2)
  • 货号：
    CSB-MP021070MO
  • 规格：
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 95% as determined by SDS-PAGE.
  • 生物活性：
    Not Test
  • 基因名：
    Serpinb2
  • Uniprot No.：
    P12388
  • 别名：
    PAI-2;Serpin B2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length
  • 来源：
    Mammalian cell
  • 分子量：
    49.8 kDa
  • 表达区域：
    1-415aa
  • 氨基酸序列
    MEELSMANTMFALNLLKQIEKSNSTQNIFISPWSISSTLAIVLLGAGGNTEQQMAKVLQFNEIGSYGITTRNPENFSGCDFAQQIQKENYPSAILQAQAGDKIHSAFSSLSSTINTPQGDYLLESANKLFGEKSARFKEEYIQLSKKYYSTEPEAVDFLECAEEAREKINSWVKTQTKGEIPNLLPEGSVDEDTKMVLVNAVYFKGKWKTPFEKKLNGLYPFRVNSHESIPVQMMFLHAKLNIGYIKDLKTQILELPHTGNISMLLLLPDEIEDASTGLELLESEINFANFNKWISKDTLDEDDVVVYIPKFKLAQSYELKSILQSMGMEDAFNKGKANFSGMSERNDLFLSEVFHQASVDVTEEGTVAAGGTGAVMTGRTGHGGPQFVADHPFLFFIMDKITHTILFVGRFSSP
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    C-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 3-7 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

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Serpinb2 Proteins

靶点详情

  • 功能：
    Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell-derived PAI-1. Not required for normal murine development or survival.
  • 基因功能参考文献：
    1. This study establishes a novel role for SerpinB2 in the stromal compartment in pancreatic ductal adenocarcinoma invasion through regulation of stromal remodelling PMID: 28346421
    2. Data suggest that the function of keratinocyte SerpinB2 is protection of the stratum corneum from proteolysis via inhibition of urokinase, thereby maintaining the integrity and barrier function of the stratum corneum, particularly during times of skin inflammation PMID: 27109612
    3. SerpinB2 plays an important role in proteostas PMID: 26083412
    4. PAI-2 is a novel regulator of venous thrombus resolution, which modulates several pathways involving both inflammatory and uPA activity mechanisms, distinct from PAI-1 PMID: 25041188
    5. SerpinB2 has previously been implicated as a mediator of DMBA/TPA-induced skin carcinogenesis PMID: 25489104
    6. The presence of SerpinB2 on the surface of MPs provides a physiological mechanism whereby cancer cell SerpinB2 can reach the extracellular milieu and access urokinase plasminogen activator (uPA). PMID: 24644264
    7. Brain metastatic cells from lung cancer and breast cancer express high levels of anti-plasminogen activator (PA) serpins, including neuroserpin and serpin B2, to prevent plasmin generation and its metastasis-suppressive effects. PMID: 24581498
    8. C/EBP-beta mediates both constitutive and LPS-induced serpinB2 mRNA expression in mouse embryonic fibroblasts and inflammatory primary macrophages. PMID: 23472114
    9. Depletion PAI-2 resulted in NLRP3- and ASC-dependent caspase-1 activation and IL-1beta secretion in macrophages upon Toll-like receptor 2 (TLR2) and TLR4 engagement. PMID: 24043792
    10. SerpinB2 can be induced by lentiviral infection in vivo. PMID: 23460840
    11. immune regulation of SerpinB2 expression plays a critical role in the development of Th2-mediated protective immunity against nematode infection by a mechanism involving CCL2 production and macrophage infiltration. PMID: 23630350
    12. PAI-2 and TG2 are downstream mediators in the antiapoptotic response triggered upon TBK1 activation. PMID: 22203995
    13. Data show that regulation of Th1 responses thus appears to be a physiological function of inflammation-associated SerpinB2. PMID: 20130210
    14. during differentiation of epidermal keratinocyte, PAI-2 expresses mainly in the more differentiated keratinocytes and may protect the terminal differentiated keratinocytes from prematuration through inhibiting involucrin expression in cornified envelope PMID: 15050365
    15. PAI-2 promotes adipose tissue development in mice via a mechanism independent of its antifibrinolytic effect PMID: 17958744
    16. SerpinB2 is a cell survival factor that modulates Rb repression of proapoptotic signal transduction PMID: 18632617
    17. Plasminogen activator inhibitor-2, but not cystatin C, inhibits the prometastatic activity of tissue inhibitor of metalloproteinases-1 in the liver.( PMID: 18681831

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  • 亚细胞定位：
    Cytoplasm. Secreted, extracellular space.
  • 蛋白家族：
    Serpin family, Ov-serpin subfamily
  • 数据库链接：

    KEGG: mmu:18788

    STRING: 10090.ENSMUSP00000009356

    UniGene: Mm.271870

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