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  4. Recombinant Mouse Peroxiredoxin-5, mitochondrial (Prdx5)

Recombinant Mouse Peroxiredoxin-5, mitochondrial (Prdx5)

  • 中文名称：
    小鼠Prdx5重组蛋白
  • 货号：
    CSB-YP018658MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Prdx5重组蛋白
  • 货号：
    CSB-EP018658MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Prdx5重组蛋白
  • 货号：
    CSB-EP018658MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Prdx5重组蛋白
  • 货号：
    CSB-BP018658MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Prdx5重组蛋白
  • 货号：
    CSB-MP018658MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Prdx5
  • Uniprot No.：
    P99029
  • 别名：
    Prdx5; Prdx6Peroxiredoxin-5; mitochondrial; EC 1.11.1.15; Antioxidant enzyme B166; AOEB166; Liver tissue 2D-page spot 2D-0014IV; PLP; Peroxiredoxin V; Prx-V; Peroxisomal antioxidant enzyme; Thioredoxin peroxidase PMP20
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    49-210
  • 氨基酸序列
    MA PIKVGDAIPS VEVFEGEPGK KVNLAELFKG KKGVLFGVPG AFTPGCSKTH LPGFVEQAGA LKAKGAQVVA CLSVNDVFVI EEWGRAHQAE GKVRLLADPT GAFGKATDLL LDDSLVSLFG NRRLKRFSMV IDNGIVKALN VEPDGTGLTC SLAPNILSQL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events.
  • 基因功能参考文献：
    1. glutamate-stimulated activation of ROS may provoke the induction of Prx V, which has an antioxidative function in glutamate-stimulated HT22 cell apoptosis, and PrxV may serve a role in neural apoptosis. PMID: 29620243
    2. PRX1 and PRX5 were upregulated in osteoblasts in the proximal tibial metaphysis of ovariectomized mice. Interestingly, PRX1 and PRX5 showed different distribution patterns, with PRX1 mainly accumulated in cell nuclei and PRX5 in the cytoplasm. PMID: 27786251
    3. The ventral signal observed from E12.5 on colocalized with motor neuron markers Isl1/2 and FoxP1 and The strong ventral signal colocalizing wtth Isl1/2 was observed in all rostrocaudal segments of the spinal cord. PMID: 25975898
    4. results suggest that PrdxV is a key mediator contributing to the regulation of LPS/TLR4-induced immune responses PMID: 23831231
    5. IMS-PRDX5 expression also attenuates the increase in cytosolic [Ca(2+)] in PASMCs during hypoxia. PMID: 24044889
    6. Prx V plays a key role in the microglial activation process through modulation of the balance between ROS/NO generation and the corresponding JNK cascade activation. PMID: 20345759
    7. PRDX5 has a role in neuroprotection PMID: 12654475
    8. Prx5 levels also appear to be highly dependent on c-Myc, and chromatin immunoprecipitation experiments showed differential occupancy of c-Myc and Prx1 complexes at E-box elements in the prx5 gene proximal promoter PMID: 19098005

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  • 亚细胞定位：
    [Isoform Mitochondrial]: Mitochondrion.; [Isoform Cytoplasmic+peroxisomal]: Cytoplasm. Peroxisome matrix.
  • 蛋白家族：
    Peroxiredoxin family, Prx5 subfamily
  • 组织特异性：
    Widely expressed.
  • 数据库链接：

    KEGG: mmu:54683

    STRING: 10090.ENSMUSP00000025904

    UniGene: Mm.279782

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