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  4. Recombinant Mouse Peripheral plasma membrane protein CASK (Cask), partial

Recombinant Mouse Peripheral plasma membrane protein CASK (Cask), partial

  • 中文名称：
    Recombinant Mouse Peripheral plasma membrane protein CASK(Cask) ,partial
  • 货号：
    CSB-YP004539MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Peripheral plasma membrane protein CASK(Cask) ,partial
  • 货号：
    CSB-EP004539MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Peripheral plasma membrane protein CASK(Cask) ,partial
  • 货号：
    CSB-EP004539MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Peripheral plasma membrane protein CASK(Cask) ,partial
  • 货号：
    CSB-BP004539MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Peripheral plasma membrane protein CASK(Cask) ,partial
  • 货号：
    CSB-MP004539MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Cask
  • Uniprot No.：
    O70589
  • 别名：
    CaskPeripheral plasma membrane protein CASK; EC 2.7.11.1; Calcium/calmodulin-dependent serine protein kinase
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins, and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1. Component of the LIN-10-LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules.
  • 基因功能参考文献：
    1. CASK T740A mutation attenuated the interaction between CASK and TBR1 in the brain. However, CASK T740A mice were generally healthy, without obvious defects in brain morphology. The most dramatic defect among the mutant mice was in extinction of associative memory, though acquisition was normal. PMID: 28234597
    2. CASK phosphorylates neurexin, modulating the interaction of liprin-alpha with the CASK-neurexin1beta-Mint1 complex. PMID: 27015872
    3. Ths data of this study implies that some phenotypic components of CASK heterozygous deletion mutation associated disorders represent systemic manifestation of metabolic stress. PMID: 27036546
    4. The findings suggest that CASK and the truncated prestin splice isoform contribute to confinement of prestin to the basolateral region of the plasma membrane. PMID: 23542924
    5. DLG1 and CASK play critical cooperative roles in maintaining the nephron progenitor population, potentially via a mechanism involving effects on FGF signaling PMID: 23661808
    6. Immunofluorescence shows colocalization of Cx43 and CASK in brain astrocytes. PMID: 22389404
    7. CASK negatively regulates PMCA4b by directly binding to it and JAM-A positively regulates it indirectly through CASK PMID: 22020416
    8. Data show that CASK expression and the appropriate localization of DLG1 and LIN7c are not essential for either epithelial polarity or intestinal homeostasis in vivo. PMID: 19726564
    9. Post-translational modifications to CASK are major regulatory steps leading to its proteasomal degradation. PMID: 19781660
    10. CASK is transcribed in mouse testis and processing may play a role in the acquisition of spserm and sperm functions. PMID: 15236336
    11. CASK and Dlg may act as a scaffold for organizing receptors and channels at the postsynaptic membrane of the neuromuscular junction. PMID: 15266631
    12. We suggest that Tbr-1/CASK protein complex regulates expression of these downstream target genes and thus modulates neuronal activity and function. PMID: 15584924
    13. analysis of structures of tetrameric L27 domain complexes formed by mLin-2/mLin-7 and Patj/Pals1 scaffold proteins PMID: 15863617
    14. Data demonstrate that calmodulin-associated serine/threonine kinase (CASK) localizes to the nucleus in undifferentiated myoblasts, but is predominantly in the cytoplasm in differentiated myotubes of the C2C12 myogenic cell line. PMID: 15965905
    15. In hippocampal CA1 and CA3 on both pre- and postsynaptic sites Neph1 colocalizes with the synaptic scaffolder CASK, and both Neph1 and Neph2 interact with the PDZ domain of CASK via their cytoplasmic tail. PMID: 16874800
    16. Cask is required for mouse survival and performs a selectively essential function without being in itself required for core activities of neurons, such as membrane excitability, Ca2+-triggered presynaptic release, or postsynaptic receptor functions. PMID: 17287346
    17. Cdk5 regulates the interaction between CASK and liprin-alpha PMID: 18054859
    18. Truncated CASK does not alter skeletal muscle or protein interactors in mice. PMID: 18642383
    19. This review discusses the first genetic model of CASK, a transgenic mouse line harboring a transgene encoding the Epstein-Barr virus latent membrane protein-1. PMID: 19847910

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  • 亚细胞定位：
    Nucleus. Cytoplasm. Cell membrane; Peripheral membrane protein.
  • 蛋白家族：
    Protein kinase superfamily, CAMK Ser/Thr protein kinase family, CaMK subfamily; MAGUK family
  • 数据库链接：

    KEGG: mmu:12361

    STRING: 10090.ENSMUSP00000111096

    UniGene: Mm.327591

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