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  4. Recombinant Mouse Pappalysin-1 (Pappa), partial

Recombinant Mouse Pappalysin-1 (Pappa), partial

  • 中文名称：
    小鼠Pappa重组蛋白
  • 货号：
    CSB-YP844461MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Pappa重组蛋白
  • 货号：
    CSB-EP844461MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Pappa重组蛋白
  • 货号：
    CSB-EP844461MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Pappa重组蛋白
  • 货号：
    CSB-BP844461MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Pappa重组蛋白
  • 货号：
    CSB-MP844461MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Pappa
  • Uniprot No.：
    Q8R4K8
  • 别名：
    Pappa; Pappalysin-1; EC 3.4.24.79; Insulin-like growth factor-dependent IGF-binding protein 4 protease; IGF-dependent IGFBP-4 protease; IGFBP-4ase; Pregnancy-associated plasma protein A; PAPP-A
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF. Isoform 2 cleaves IGFBP-4 very slowly compared to PAPP-A, but its ability to cleave IGFBP-5 is unaffected.
  • 基因功能参考文献：
    1. Inducible knockdown of PAPP-A gene expression in adult female mice extends life span. PMID: 28600811
    2. Intrinsic mitochondrial oxidative capacity was significantly increased in skeletal muscle of aged PAPP-A KO compared to WT mice. Moreover, 18-month-old PAPP-A KO mice exhibited significantly enhanced endurance running on a treadmill. Thus, PAPP-A deficiency in mice is associated with indices of healthy skeletal muscle function with age. PMID: 27086066
    3. STC2 is involved in regulating PAPP-A activity during the development of atherosclerosis PMID: 26983002
    4. Study demonstrates proof-of-principle and provides feasibility for a novel therapeutic strategy to inhibit atherosclerotic plaque burden by selective targeting of PAPP-A. PMID: 26733326
    5. stimulation of PAPP-A expression by intermittent PTH treatment contributes to PTH bone anabolism in mice PMID: 26297833
    6. PAPP-A affects fascicle structure, thereby affecting tendon phenotype. PMID: 26306763
    7. tissue-specific expression differentially affected during aging PMID: 24815423
    8. PAPP-A has a role in development of advanced plaque with necrotic cores and buried fibrous caps in the brachiocephalic artery PMID: 24506074
    9. these data indicate preferential impact of PAPP-A deficiency on visceral fat in the mouse that is associated with enhanced insulin receptor signaling PMID: 24045868
    10. Studies show a conditional PAPP-A knockout (KO) model for efficacy of tamoxifen-induced floxed PAPP-A excision in various tissues and indicate a significant reduction of neointimal formation after unilateral carotid artery ligation. PMID: 23748359
    11. absence of PAPP-A is associated with resistance to the development of indicators of diabetic nephropathy in mice PMID: 23881937
    12. Pregnancy-associated plasma protein (PAPP)-A expressed in the mammary gland controls epithelial cell proliferation and differentiation. PMID: 22899098
    13. Data conclude that PAPP-A proteolytic activity is required for the lesion-promoting effect of PAPP-A and that its specificity must be directed against IGFBP-4. PMID: 23161866
    14. observations revealed a novel function of prohibitin as a chaperone of p53. Further, they suggest that binding of denatured p53 in intron 1 causes an enhancer effect and increases the transcription of PAPP-A PMID: 21829624
    15. PAPP-A increases bone formation primarily by increasing IGF bioavailability and other alternative pathways may play a negligible role in mediating the anabolic effect of PAPPA in bone. PMID: 20144555
    16. PAPPA modulates ovarian function and female fertility by controlling the bioavailability of ovarian insulin-like growth factors. PMID: 20130263
    17. Renal expression of Irs1 and Mt1 was increased by PappA(-/-) as well as by mutations that reduce IGF-1 in serum. PMID: 20197085
    18. Major contributors to extended life span of PAPP-A knockout mice are delayed occurrence of fatal neoplasias and decreased incidence of age-related degenerative changes. PMID: 20351075
    19. gonadotropin-stimulated PAPP-A gene expression plays a role in the follicle development, ovulation, and luteogenesis in the mammalian ovary PMID: 11956166
    20. the PAPP-A mRNA level in mouse placenta was lower compared to that in human placenta by at least two orders of magnitude PMID: 12213189
    21. Mice homozygous for targeted disruption of the PAPPA gene were viable but 60% the size of wild-type littermates at birth. The impact of the mutation was exerted during the early embryonic period prior to organogenesis. PMID: 14973274
    22. PAPP-A acts as a potent anabolic factor in the regulation of bone formation. PMID: 16946002
    23. PAPP-A-deficient mice are resistant to neointimal formation after injury. PMID: 16959843
    24. PAPP-A requires the formation of intermolecular proteinase-inhibitor disulfide bonds and glycosaminoglycan covalently bound to the inhibitor PMID: 17145752
    25. PAPP-A plays a critical role in lesion development in a mouse model of atherosclerosis, at least in part, through amplification of local IGF-I bioavailability. PMID: 17510462
    26. Results identified PAPP-A as a novel regulator of prenatal/postnatal growth and skeletal muscle formation in vivo. PMID: 17901236
    27. Study show that neither reduced 'rate of living' nor altered glucose-insulin homeostasis can be considered key determinants of the enhanced longevity of PAPP-A KO mice. PMID: 18566100
    28. Splenic T cells of old PAPPA(-/-) mice have high levels of activation antigens and cytokine production, and also elicit Ig production by autologous B cells at levels equivalent to young wild-type mice. PMID: 19549878

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Peptidase M43B family
  • 组织特异性：
    Detected in kidney, spleen, brain, ovary, breast, skin, prostate, uterus, and placenta.
  • 数据库链接：

    KEGG: mmu:18491

    STRING: 10090.ENSMUSP00000081545

    UniGene: Mm.317854

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