Recombinant Mouse POU domain, class 5, transcription factor 1 (Pou5f1)

1. Oct4 is involved in DNA methylation through the regulation of Dnmt1 transcription, especially during the early stages of mouse pre-implantation embryo development. PMID: 30140294
2. Zfp127 is a novel regulator of Oct4, and may become a potent target to improve cellular reprogramming. PMID: 29335068
3. Here we describe an optimized DamID method coupled with next-generation sequencing (DamID-seq) in mouse cells and demonstrate the identification of the binding sites of two TFs, POU5F1 (also known as OCT4) and SOX2, in as few as 1000 embryonic stem cells (ESCs) and neural stem cells (NSCs), respectively. PMID: 29572359
4. These results indicate a role for Oct4 in orchestrating multiple fates and enabling expansion, correct patterning and lineage choice in the postimplantation epiblast. PMID: 29915126
5. Acidic pH induced OCT-4 expression in fibroblasts and stromal cells in tumor microenvironment. PMID: 27302093
6. Threonine(343) based OCT4-phosphorylation is crucial for the maintenance of ESC pluripotency and interaction with SOX2. PMID: 28988986
7. These results demonstrated that OCT4 phosphorylation on serine 347 by JNKs plays an important role in its stability, transcriptional activities, and self-renewal of mouse ESCs PMID: 29153991
8. the epigenetic status of Oct4 and Nanog genes confirm that pre-induced pluripotent stem cells belong to an RVTg+OCT4+NANOG- state PMID: 27622636
9. These observations support a role for YY1 meditating and/or regulating the interaction of OCT4 and SOX2 at a posttranscriptional level. PMID: 28682643
10. The results revealed that the synthesized complex decoy can concomitantly target Sox2 and Oct4, which subsequently represses the stemness properties of mESCs compared to controls through decreasing cell viability, arresting cell cycle in G0 /G1 phases, inducing apoptosis, and modulating differentiation in mESCs despite the presence of 2i/LIF in cell culture. PMID: 28833847
11. Tip110 deletion impaired embryonic and stem cell development involving downregulation of stem cell factors Nanog, Oct4, and Sox2. PMID: 28436127
12. Nanog, Oct4 and Tet1 interplay in establishing stem cell pluripotency has been described. PMID: 27146218
13. Chromatin accessibility at OCT4-bound sites requires the chromatin remodeller BRG1, which is recruited to these sites by OCT4 to support additional transcription factor binding and expression of the pluripotency-associated transcriptome. PMID: 28287392
14. data infer that OCT4 expression may have a direct effect on partial cardiomyocyte reprogramming of MSCs and suggest a new mechanism(s) associated with MSC multipotency and a requirement for crosstalk with the cardiac microenvironment PMID: 29216265
15. Regulation of Oct4 by SirT1 may link stem cell development to environmental conditions, and it may provide strategies to manipulate epiblast cell state. PMID: 27732856
16. we suggest that the activity of Oct4 DE and PE is regulated by the repressive histone marks and DNA methylation in a cell-type-specific manner. PMID: 28157483
17. PRDM14 recruited OCT3/4 to the enhancer regions of naive pluripotency genes via TET-base excision repair-mediated demethylation. PMID: 27866876
18. High POU5F1 expression is associated with disruption in differentiation and spermatogenesis. PMID: 27486267
19. Three regulating complexes centered by Sox2-Oct4, Nanog, and Lrh1 maintain Oct4 expression in pluripotent stem cells in mice. [review] PMID: 28731785
20. OCT4 is an integral and necessary component of signal-regulated transcriptional processes required for tissue-specific responses. PMID: 27499297
21. Maintenance of pluripotency is regulated by a network of transcription factors coordinated by Oct4, Sox2, and Nanog; Trim24 significantly improved efficiency of cellular reprogramming, demonstrating its direct functionality in establishing pluripotency. PMID: 27773674
22. ATOX1 appeared ubiquitously expressed throughout the cells until compaction; in subsequent embryo stages, ATOX1 relocalized to cytoplasmic perinuclear domains in the inner cell mass. Silencing of Oct4 did not affect Atox1 expression, but silencing of Atox1 at the 2-cell stage strongly diminished Oct4 expression in 16-cell embryos. PMID: 28711491
23. smooth muscle cell (SMC)-specific conditional knockout of Oct4 in Apoe-/- mice resulted in increased lesion size and changes in lesion composition that are consistent with decreased plaque stability, including a thinner fibrous cap, increased necrotic core area, and increased intraplaque hemorrhage. PMID: 27183216
24. In mouse model of acute uterine injury, Nanog homebox (NANOG) expression reached a peak at 6 h, while sex-determining region Y-box2 (SOX2) and octamer-binding protein 4 (OCT4) peaked later at 12 h after lipopolysaccharide (LPS) treatment. PMID: 28253866
25. Here, the authors present the first structure of mouse GCNF DNA-binding domain in complex with the Oct4 DR0. The overall structure revealed two molecules bound in a head-to-tail fashion on opposite sides of the DNA at a DR0 motif located within the Oct4 promoter. PMID: 27984042
26. To our knowledge, this is the first report on lineage reprogramming of TILs using protein stem cell transcription factors delivered directly to the nucleus. PMID: 27084449
27. In late preimplantation, Oct4 served as a chromatin opener to create transcriptional permissive states at Xm-Xist/Tsix genomic loci. In parthenogenetic embryos, Rnf12 overdose caused Xm-Xist derepression via Xm-Tsix repression; physiological Rnf12 levels were essential for Xm-Xist silencing maintenance in fertilized embryos. PMID: 27788132
28. Critical POU domain residues confer Oct4 uniqueness in somatic cell reprogramming. PMID: 26877091
29. Hierarchical Oct4 binding in concert with primed epigenetic rearrangements during somatic cell reprogramming has been described. PMID: 26832419
30. One-week administration of valproic acid followed by one-week forced expression of Oct4 enhanced myelination by converting transduced cells to myelinating oligodendrocytes PMID: 26804242
31. Aurkb phosphorylates Oct4(S229) during G2/M phase, leading to the dissociation of Oct4 from chromatin, whereas PP1 binds Oct4 and dephosphorylates Oct4(S229) during M/G1 transition, which resets Oct4-driven transcription for pluripotency and the cell cycle. PMID: 26880562
32. Bcl3 Bridges LIF-STAT3 to Oct4 Signaling in the Maintenance of Naive Pluripotency. PMID: 26303070
33. Oct3/4 plays a crucial role in mediating CSCs to induce cardiac regeneration. PMID: 26704423
34. OCT4-SOX2 configuration that dimerizes on a Hoxb1-like composite, a canonical element with juxtaposed individual binding sites, plays a more critical role in the induction and maintenance of pluripotency. PMID: 26314899
35. The long noncoding RNA Gm15055 is highly expressed in mouse embryonic stem cells and its expression is maintained by OCT4. PMID: 26615201
36. The Oct4 distal enhancer interacts with genomic loci that exhibit open chromosome features and contain active histone marks. PMID: 26435056
37. In summary, the data presented here reveal that TRIM32 directly regulates at least two of the four Yamanaka Factors (cMyc and Oct4), to modulate cell fate transitions. PMID: 26307407
38. Tgif1 counterbalances the activity of core pluripotency factors, Oct4, Sox2, and Nanog, in mouse embryonic stem cells. PMID: 26411691
39. Pluripotency transcription factors Nanog and Oct4 positively modulate Sod2 gene transcription in induced pluripotent stem cells. PMID: 26642061
40. Results suggest that Oct4 and Sox 2 transcription factors can decrease nucleosome occupancy in vivo at poised genes, but do not alter in vivo nucleosome occupancy at active genes. PMID: 25992972
41. This data highlights a crucial role for Oct4A in the progression and metastasis of EOC. Targeting Oct4A may prove to be an effective strategy in the treatment and management of epithelial ovarian tumours. PMID: 26260289
42. YAP1 regulates OCT4 activity and SOX2 expression to facilitate self-renewal of stem-like cell PMID: 25754111
43. findings demonstrate that chromatin organization and transcriptional programs are intimately connected in ESCs and that the dynamic positioning of the Oct4 alleles is associated with the transition from pluripotency to lineage specification. PMID: 25748933
44. The BET family member BRD4 interacts with OCT4 and regulates pluripotency gene expression PMID: 25684227
45. Pontin functions as an essential coactivator for Oct4-dependent large intergenic noncoding RNA expression in mouse embryonic stem cells. PMID: 25857206
46. Reptin plays a key role in maintaining the pluripotency of embryonic stem cells and in establishing the pluripotency during reprogramming of somatic cells by regulation of Oct4-mediated gene regulation PMID: 25185564
47. The mechanism of hypoxia induction of germ cell pluripotency involves HIF1alpha stabilization and Oct4 deregulation. PMID: 25226357
48. Study showed that Ezh2 mRNA expression was inversely correlated with Oct4 and Sox2, but Oct4 and Sox2 negatively affect Ezh2; additionally, Oct4 and Sox2 were negative regulators of Ezh2 primarily on a post-translation level. PMID: 25501223
49. OCT4 and SOX2 are the primary transcription factors recruiting SCC to regulatory regions of pluripotency genes; the XPC subunit is essential for interaction with the two proteins PMID: 25901318
50. Oct3/4 directly bound to the promoter region of the E2F3a gene and positively regulated expression of E2F3a in embryonic stem cells. PMID: 25727014

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KEGG: mmu:18999

STRING: 10090.ENSMUSP00000025271

UniGene: Mm.17031