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  4. Recombinant Mouse POU domain, class 3, transcription factor 1 (Pou3f1)

Recombinant Mouse POU domain, class 3, transcription factor 1 (Pou3f1)

  • 中文名称：
    小鼠Pou3f1重组蛋白
  • 货号：
    CSB-YP018396MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Pou3f1重组蛋白
  • 货号：
    CSB-EP018396MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Pou3f1重组蛋白
  • 货号：
    CSB-EP018396MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Pou3f1重组蛋白
  • 货号：
    CSB-BP018396MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Pou3f1重组蛋白
  • 货号：
    CSB-MP018396MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Pou3f1
  • Uniprot No.：
    P21952
  • 别名：
    Pou3f1; Oct6; Otf-6; Otf6; Scip; POU domain; class 3; transcription factor 1; Octamer-binding protein 6; Oct-6; Octamer-binding transcription factor 6; OTF-6; POU domain transcription factor SCIP
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-449
  • 氨基酸序列
    MATTAQYLPR GPGGGAGGTG PLMHPDAAAA AAAAAERLHA GAAYREVQKL MHHEWLGAGA GHPVGLAHPQ WLPTGGGGGG DWAGGPHLEH GKAGGGGTGR ADDGGGGGGF HARLVHQGAA HAGAAWAQGG TAHHLGPAMS PSPGAGGGHQ PQPLGLYAQA AYPGGGGGGL AGMLAAGGGG AGPGLHHALH EDGHEAQLEP SPPPHLGAHG HAHGHAHAGG LHAAAAHLHP GAGGGGSSVG EHSDEDAPSS DDLEQFAKQF KQRRIKLGFT QADVGLALGT LYGNVFSQTT ICRFEALQLS FKNMCKLKPL LNKWLEETDS SSGSPTNLDK IAAQGRKRKK RTSIEVGVKG ALESHFLKCP KPSAHEITGL ADSLQLEKEV VRVWFCNRRQ KEKRMTPAAG AGHPPMDDVY APGELGPGGG SASPPSAPPP PPPAALHHHH HHTLPGSVQ
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Acts as a transcriptional activator when binding cooperatively with SOX4, SOX11, or SOX12 to gene promoters. Acts as a transcriptional repressor of myelin-specific genes.
  • 基因功能参考文献：
    1. An early response to nerve injury has been identified that controlled by HDAC2, which coordinates the action of other chromatin remodeling enzymes to induce the upregulation of Oct6, a key transcription factor for Schwann cells development. PMID: 28139683
    2. Oct6 predominantly forms homodimers on MORE cis elements in NS5 mouse neural stem cells PMID: 26265007
    3. Pou3f1 promotes the neural fate commitment of pluripotent stem cells through a dual role, activating internal neural induction programs and antagonizing extrinsic neural inhibitory signals PMID: 24929964
    4. Crystal structure of the dimeric Oct6 POU domain bound to palindromic MORE motif DNA PMID: 21117060
    5. is induced by interferonand contributes to dsRNA-mediated transactivation of innate immunity PMID: 20687925
    6. POU3F1, but not POU5F1, is an intrinsic regulator of GDNF-induced survival and self-renewal of mouse spermatogonial stem cells. PMID: 20181621
    7. A cell type-specific allele of the POU gene Oct-6 reveals Schwann cell autonomous function in nerve development and regeneration PMID: 12198163
    8. Brn-2 function largely overlaps with that of Oct-6 in driving the transition from promyelinating to myelinating Schwann cells PMID: 12782656
    9. Data show that Oct-6 normally represses Wnt1 expression in the early diencephalon and replacement by Brn-1 as a weaker inhibitor is no longer sufficient to maintain the necessary level of repression in the mouse mutant. PMID: 19527706

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    POU transcription factor family, Class-3 subfamily
  • 数据库链接：

    KEGG: mmu:18991

    STRING: 10090.ENSMUSP00000137374

    UniGene: Mm.297371

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