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  4. Recombinant Mouse Nuclear receptor coactivator 1 (Ncoa1), partial

Recombinant Mouse Nuclear receptor coactivator 1 (Ncoa1), partial

  • 中文名称：
    小鼠Ncoa1重组蛋白
  • 货号：
    CSB-YP015539MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Ncoa1重组蛋白
  • 货号：
    CSB-EP015539MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Ncoa1重组蛋白
  • 货号：
    CSB-EP015539MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Ncoa1重组蛋白
  • 货号：
    CSB-BP015539MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Ncoa1重组蛋白
  • 货号：
    CSB-MP015539MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Ncoa1
  • Uniprot No.：
    P70365
  • 别名：
    Ncoa1; Src1; Nuclear receptor coactivator 1; NCoA-1; EC 2.3.1.48; Nuclear receptor coactivator protein 1; mNRC-1; Steroid receptor coactivator 1; SRC-1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3.
  • 基因功能参考文献：
    1. Sumoylation of RORgammaT regulates TH17 differentiation and thymocyte development via histone acetyltransferase KAT2A, which stabilizes the binding of SRC1 to enhance RORgammaT transcription factor activity. PMID: 30451821
    2. Although the SRC-1 expression in female mice was lower than that in males under normal conditions, its expression in females was more dominant after spinal cord injury. The expression of Profilin-1 in both sexes increased first, and then decreased at 3 days after injury. However, there was a second increase in females at 7 days after injury. PMID: 28816099
    3. SRC-1 can impact osteoblast function in an estrogen receptor-independent manner. PMID: 28286232
    4. The results suggest that biochanin A activates RORgamma-dependent IL-17 transcription through the enhancement of STAT3 phosphorylation and STAT3-mediated recruitment of NCOA1 to RORgamma. PMID: 28579428
    5. ubiquitination of K446 limits RORgammat-mediated Th17 differentiation by inhibiting the recruitment of coactivator SRC1 PMID: 27430721
    6. Loss of SRC-1 is associated with high Blood Pressure and Aortic Stiffness. PMID: 28006821
    7. local E2 inhibition could induce aberrant actin polymerization and also showed an important role of SRC-1 in the mediation of local E2 action on hippocampal synaptic plasticity by regulation of actin cytoskeleton dynamics PMID: 27866972
    8. SRC-1/3 are required for cardiomyocyte proliferation and differentiation at earlier developmental stages, and their dysfunction causes NCC-like abnormalities in the hearts of newborn and adult mice. PMID: 26221073
    9. While hippocampal SRC-1 was significantly downregulated by orchidectomy (ORX), its expression was rescued by treatment with testosterone in a dose-dependent manner. Testosterone regulates synaptic proteins involves AR, estrogen receptors and SRC-1. PMID: 26607693
    10. fetal lungs produce signals to initiate labor when mature, and SRC-1/-2-dependent production of SP-A and PAF is crucial for this process PMID: 26098214
    11. Consequently, SRC-1 null mice displayed low TAT expression and presented with hypertyrosinemia and corneal alterations, 2 clinical features observed in the human syndrome of TAT deficiency. PMID: 25148457
    12. the effect of orchidectomy (ORX) on the expression of SRC-1 PMID: 24945110
    13. Letrozole induces dramatic decrease of SRC-1 in the medial septal, hippocampus, medial habenular nucleus, arcuate hypothalamic nucleus and superior colliculus. PMID: 24434281
    14. SRC1 regulates anxiety responses in male and female mice. PMID: 23927929
    15. The effects of gonadectomy on the expression of SRC-1 suggest a distinct regulatory mode between female and male gonad hormones in the regulation of hippocampal SRC-1 protein. PMID: 22623226
    16. A previously unidentified 70-kDa SRC-1 proteolytic isoform is highly elevated both in the endometriotic tissue of mice with endometriosis and in endometriotic stromal cells biopsied from patients with endometriosis. PMID: 22660634
    17. Daidzein increases protein level of SRC-1 in cultured osteoblasts. PMID: 22088592
    18. Localization and sex-difference of steroid receptor coactivator-1 immunoreactivities in the brain of adult female and male mice. PMID: 21145336
    19. SRC-1 plays key roles in MMTV-neu mediated mammary tumorigenesis and response to anti-proliferative PPAR ligands. PMID: 21080969
    20. SRC-1 and TIF2 can modulate the expression of the uncoupling protein 3 in an antagonistic manner and that enhanced SRC-1 levels in TIF2-deficient myofibers are critically involved in the metabolic changes of TIF2(i)skm-/- mice. PMID: 21035760
    21. SRC-1 acts as a critical mediator of glucose homeostasis in the liver by adjusting the transcriptional activity of key genes involved in the hepatic glucose production machinery. PMID: 21109193
    22. Results demonstrate that NCOA1 and NCOA3 cooperatively regulate placental morphogenesis and embryo survival. PMID: 20685850
    23. the T(3)-mediated decrease in TSH and changes in AP were attenuated in SRC-1(-/-) mice; SRC-1 deficiency altered the expression of only some of the T(3)-responsive genes PMID: 11897691
    24. the findings clearly implicate dual regulation of ERalpha-dependent function by SRC-1 and SRC-2 in the intact female brain. PMID: 12089347
    25. Data show that TIF2 plays a critical role in mouse reproductive functions. Though TIF2, SRC-1, and p/CIP exhibit sequence homology and similar activity in vitro, their genetic eliminations result in distinct pathologies in vivo. PMID: 12138202
    26. The p160 family coactivator SRC1 interacts with BAF57. The ability of p160 coactivators to potentiate transcription by the estrogen receptor is dependent on BAF57. PMID: 12145209
    27. in the absence of thyroid hormone receptor alpha or thyroid hormone receptor beta, steroid receptor coactivator-1 is important for normal growth and it modulates these receptors effects on heart rate PMID: 12388168
    28. SRC-1-/- mice are prone to obesity due to reduced energy expenditure. The relative level of TIF2/SRC-1 can modulate energy metabolism. PMID: 12507421
    29. SRC-1 knockout mice exhibit moderate motor dysfunction and delayed development of cerebellar Purkinje cells. PMID: 12514218
    30. Developmental expression profiles and distinct regional estrogen responsiveness suggest a novel role for the steroid receptor coactivator SRC-1 as discriminative amplifier of estrogen signaling in the brain. PMID: 12551846
    31. a coactivator such as SRC-1 could modulate the in vivo action of thyroid hormone receptor beta mutants in a tissue-dependent manner. PMID: 12933689
    32. NCoA-1/SRC-1 is an essential coactivator of STAT5 that binds to the FDL motif in the alpha-helical region of the STAT5 transactivation domain PMID: 12954634
    33. findings establish that, in mice, loss of steroid receptor coactivator-1 leads to skeletal resistance to estrogen PMID: 14563705
    34. The overall abnormality in SRC-1(+/-)/TIF2(-/-) and SRC-1(-/-)/TIF2(-/-) mutant testes, include spermatid maturation defects, increase in Sertoli cell lipid stores, loss of immature germ cells, and formation of giant multinucleated spermatids PMID: 15070739
    35. SRC-1 is essential for the maintenance of bone mass by sex hormones, but not for the catabolic action of glucocorticoid. PMID: 15312245
    36. SRC-1 concentrates in Sertoli cell nuclei in the absence of TIF2 and appears to negatively influence androgen receptor (AR)activity, thereby counterbalancing the TIF2-stimulated AR activity. PMID: 15983373
    37. SRC-1 is involved in the down-regulation of PR target gene expression in the luminal and glandular epithelial compartments of the uterus after chronic progesterone treatment by regulating PR activity.(SRC1) PMID: 16135805
    38. SRC-1 is the primary coactivator for PR in uterus. PMID: 16141356
    39. SRC-1 has a role in mediating actions of glucocorticoids in pituitary and liver PMID: 16339206
    40. p/CIP and SRC-1 play critical roles in energy balance by controlling both energy intake and energy expenditure. PMID: 16459312
    41. histone acetyltransferase binding to ORC-1 might play an important physiological role in human progesterone receptor signaling PMID: 16645042
    42. SRC1-deficient P19 cells showed severely compromised retinoid-induced responses, in agreement with the supposed role of SRC1 as a retinoic acid recepetor coactivator. PMID: 16723356
    43. Both the SRC-1 transcript and protein levels were elevated and the population of SRC-1-positive cells was found to be higher in the mature neurons than in the immature neurons. PMID: 17198688
    44. steroid receptor function in the different hippocampal subregions, acute changes of HPA axis activity or reactivity are not mediated by hippocampal changes in expression of this coactivator family PMID: 17854779
    45. overexpression of SRC1a, but not SRC1e, increased both efficacy and potency of the glucocorticoid receptor-mediated repression of the forskolin-induced CRH promoter PMID: 18006628
    46. Glucose decreased PPARalpha interaction with fatty acid metabolites and steroid receptor coactivator-1 while increasing PPARalpha interaction with DNA. PMID: 18055466
    47. SRC-1 specifically promotes metastasis without affecting primary tumor growth through mediating Ets-2-mediated HER2 expression and activating CSF-1 expression for macrophage recruitment PMID: 19109434
    48. SRC-1 in mouse prostate carcinogenesis is nonessential and its expression is relative constant; the loss of SRC-1 function may be compensated by SRC-3 overexpression during prostate tumorigenesis in SRC-1(-/-) mice PMID: 19305643
    49. SRC-1 promotes breast cancer in mice invasiveness and metastasis by coactivating PEA3-mediated Twist expression. PMID: 19383905
    50. The report demonstrates the in vivo interaction of steroid receptor coactivator (SRC)-1 and the activation function-2 domain of the thyroid hormone receptor (TR) beta. PMID: 19406944

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    SRC/p160 nuclear receptor coactivator family
  • 组织特异性：
    Widely expressed.
  • 数据库链接：

    KEGG: mmu:17977

    STRING: 10090.ENSMUSP00000082971

    UniGene: Mm.301039

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