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  4. Recombinant Mouse Nuclear factor 1 B-type (Nfib)

Recombinant Mouse Nuclear factor 1 B-type (Nfib)

  • 中文名称：
    小鼠Nfib重组蛋白
  • 货号：
    CSB-YP015755MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Nfib重组蛋白
  • 货号：
    CSB-EP015755MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Nfib重组蛋白
  • 货号：
    CSB-EP015755MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Nfib重组蛋白
  • 货号：
    CSB-BP015755MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Nfib重组蛋白
  • 货号：
    CSB-MP015755MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Nfib
  • Uniprot No.：
    P97863
  • 别名：
    Nfib; Nuclear factor 1 B-type; NF1-B; Nuclear factor 1/B; CCAAT-box-binding transcription factor; CTF; Nuclear factor I/B; NF-I/B; NFI-B; TGGCA-binding protein
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-570
  • 氨基酸序列
    MYSPICLTQ DEFHPFIEAL LPHVRAIAYT WFNLQARKRK YFKKHEKRMS KDEERAVKDE LLSEKPEIKQ KWASRLLAKL RKDIRQEYRE DFVLTVTGKK HPCCVLSNPD QKGKIRRIDC LRQADKVWRL DLVMVILFKG IPLESTDGER LMKSPHCTNP ALCVQPHHIT VSVKELDLFL AYYVQEQDSG QSGSPSHSDP AKNPPGYLED SFVKSGVFNV SELVRVSRTP ITQGTGVNFP IGEIPSQPYY HDMNSGVNLQ RSLSSPPSSK RPKTISIDEN MEPSPTGDFY PSPNSPAAGS RTWHERDQDM SSPTTMKKPE KPLFSSTSPQ DSSPRLSTFP QHHHPGIPGV AHSVISTRTP PPPSPLPFPT QAILPPAPSS YFSHPTIRYP PHLNPQDTLK NYVPSYDPSS PQTSQPNSSG QVVGKVPGHF TPVLAPSPHP SAVRPVTLTM TDTKPITTST EGEAASPTAT TYTASGTSQA NRYVGLSPRD PSFLHQQQLR ICDWTMNQNG RHLYPSTSED TLGITWQSPG TWASLVPFQV SNRTPILPAN VQNYGLNIIG EPFLQAETSN
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcriptional activator of GFAP, essential for proper brain development. Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.
  • 基因功能参考文献：
    1. \Nfib hemizygous mice are relatively resistant to hyperoxia compared to wild-type littermates. Nfib hemizygous lungs had significant downregulation of genes involved in redox signaling and inflammatory pathways. PMID: 28830981
    2. NFIB overexpression interacts with Rb/p53 deletion to promote small cell lung cancer in a mouse model PMID: 27613844
    3. High NFIB levels are associated with expansive growth of a poorly differentiated and almost exclusively E-cadherin (CDH1)-negative invasive tumor cell population. PMID: 27373156
    4. Loss of Nfib resulted in a severe delay in intermediate progenitor cell generation while, conversely, overexpression of NFIX led to precocious intermediate progenitor cell generation. PMID: 27965439
    5. Knockdown of NFIB in Drosha-deficient hippocampal neural stem cells restores neurogenesis, suggesting that the Drosha/NFIB mechanism robustly prevents oligodendrocyte fate acquisition in vivo. PMID: 27545503
    6. Nfib is necessary and sufficient to increase chromatin accessibility at a large subset of the intergenic regions. Nfib promotes pro-metastatic neuronal gene expression programs and drives the metastatic ability of small cell lung cancer cells. PMID: 27374332
    7. Loss of Nfib expression resulted in prostatic hyperplasia. NFIB knockdown studies demonstrated that loss of NFIB drives increased AR expression and superinduction of a subset of AR target genes. PMID: 26677878
    8. NFIB-STAT5 modules, possibly in conjunction with other transcription factors, control cell-specific genetic programs. PMID: 24678731
    9. Study revealed both novel and broad functions of NFIB in regulating the generation of cortical projection neurons, including radial glial differentiation, neuronal migration and axon projection PMID: 23749646
    10. downregulation of Ezh2 transcription by NFIB is an important component of the process of neural progenitor cell differentiation during cortical development PMID: 24553933
    11. transcription factor NFIB is an unanticipated coordinator of stem cell behaviour PMID: 23389444
    12. Functional studies indicate that NFIB regulates cell viability and proliferation during transformation PMID: 21764851
    13. Mesenchymal Nfib regulates both mesenchymal and epithelial cell proliferation through multiple pathways and that mesenchymal NFI-B-mediated signals are essential for the maturation of distal lung epithelium. PMID: 21513708
    14. Data show that the -588/-560 region of nuclear factor I is involved in the insulin-mediated repression of thyroid stimulating hormone beta. PMID: 20685655
    15. NFIB/X and NFY repressors contribute differentially to organ-specific regulation of the VWF promoter in transgenic mice. PMID: 20431063
    16. data indicate that defects in midline glia and cingulate cortex neurons are associated with the callosal dysgenesis seen in Nfib-deficient mice, and provide insight into how the development of these cellular populations is controlled at a molecular level PMID: 19961580
    17. Nuclear factor I-B (Nfib) deficient mice have severe lung hypoplasia PMID: 11850179
    18. Data show that nuclear factor I (Nfi)b-deficient mice possess unique defects in lung maturation and exhibit callosal agenesis and forebrain defects that are similar to, but more severe than, those seen in Nfia-deficient animals. PMID: 15632069
    19. Data demonstrate a role for Nfib in hippocampal fissure and dentate gyrus formation, and that distinct glial bundles are critical for correct hippocampal morphogenesis. PMID: 19020026
    20. Data demonstrate that Nfib plays an important role in the generation of precerebellar mossy fiber neurons, and may do so at least in part by regulating neurogenesis. PMID: 19107796

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    CTF/NF-I family
  • 组织特异性：
    Highest expression in lung, skeletal muscle and heart. Lower levels in liver, kidney and brain. Very low levels in testis and spleen.
  • 数据库链接：

    KEGG: mmu:18028

    STRING: 10090.ENSMUSP00000052863

    UniGene: Mm.317947

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