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  4. Recombinant Mouse Next to BRCA1 gene 1 protein (Nbr1), partial

Recombinant Mouse Next to BRCA1 gene 1 protein (Nbr1), partial

  • 中文名称：
    小鼠Nbr1重组蛋白
  • 货号：
    CSB-YP015508MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Nbr1重组蛋白
  • 货号：
    CSB-EP015508MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Nbr1重组蛋白
  • 货号：
    CSB-EP015508MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Nbr1重组蛋白
  • 货号：
    CSB-BP015508MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Nbr1重组蛋白
  • 货号：
    CSB-MP015508MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Nbr1
  • Uniprot No.：
    P97432
  • 别名：
    Nbr1; M17s2Next to BRCA1 gene 1 protein; Membrane component chromosome 17 surface marker 2 homolog; Neighbor of BRCA1 gene 1 protein
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets.
  • 基因功能参考文献：
    1. NBR1 is increased in adipose tissue macrophages in obese mice. The NBR1-MEKK3 complex is important in JNK activation in macrophages. PMID: 25043814
    2. NBR1 phosphorylation by GSK3 at Thr586 prevents the aggregation of ubiquitinated proteins and their selective autophagic degradation. PMID: 24879152
    3. In a mouse model of Huntington disease, NBR1 protein levels were decreased in all brain regions analyzed early in the disease, whereas at late stages they accumulated in the striatum and hippocampus, but not in the cortex. PMID: 23295856
    4. MURF2 expression parallels that of the autophagy-associated proteins LC3, p62/SQSTM1 and nbr1 PMID: 21185285
    5. Results define Nbr1 as a negative regulator of ligand-mediated receptor tyrosine kinase degradation and reveal the interplay between its various regions for protein localization and function. PMID: 20937771
    6. NBR1 is a novel PB1 adapter in Th2 differentiation and asthma. PMID: 20808283
    7. might contribute to the metastasis of ovarian cancer to the peritoneum by initiating cell attachment to the mesothelial epithelium via binding to mesothelin PMID: 14676194
    8. The nbr1 UBA domain binds to lysine-48 and -63 linked polyubiquitin-B chains. Nbr1 also binds to the autophagic effector protein LC3-A via a novel binding site. PMID: 19427866
    9. findings suggest a critical function for NBR1 in the regulation of receptor trafficking and provide a mechanism for down-regulation of signaling by Spred2 via NBR1. PMID: 19822672

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  • 亚细胞定位：
    Cytoplasm. Cytoplasmic vesicle, autophagosome. Lysosome. Cytoplasm, myofibril, sarcomere, M line.
  • 组织特异性：
    Expressed in brain.
  • 数据库链接：

    KEGG: mmu:17966

    STRING: 10090.ENSMUSP00000099387

    UniGene: Mm.489817

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