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  4. Recombinant Mouse Nardilysin (Nrd1), partial

Recombinant Mouse Nardilysin (Nrd1), partial

  • 中文名称：
    小鼠Nrdc重组蛋白
  • 货号：
    CSB-YP806839MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Nrdc重组蛋白
  • 货号：
    CSB-EP806839MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Nrdc重组蛋白
  • 货号：
    CSB-EP806839MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Nrdc重组蛋白
  • 货号：
    CSB-BP806839MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Nrdc重组蛋白
  • 货号：
    CSB-MP806839MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Nrdc
  • Uniprot No.：
    Q8BHG1
  • 别名：
    Nrdc; Nrd1; Nardilysin; EC 3.4.24.61; N-arginine dibasic convertase; NRD convertase; NRD-C; Nardilysin convertase
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs.
  • 基因功能参考文献：
    1. Here, the authors have demonstrated that nardilysin regulates gastric inflammation caused by Helicobacter felis infection or forced expression of prostaglandin. Metaplastic changes following gastric inflammation were suppressed by the deletion of nardilysin. Furthremore, the deletion of nardilysin significantly suppressed N-methyl-N-nitrosourea (MNU)-induced gastric tumorigenesis in the murine stomach. PMID: 28230087
    2. Nardilysin Is Required for Maintaining Pancreatic beta-Cell Function PMID: 27385158
    3. critical regulator of body temperature homoeostasis PMID: 24492630
    4. deletion of nardilysin prevents the development of diet-induced steatohepatitis and liver fibrogenesis PMID: 24849253
    5. It controls Amyloid beta plaque formation through the regulation of a-secretase. PMID: 23954170
    6. Identification and characterization of nardilysin as a novel dimethyl H3K4-binding protein involved in transcriptional regulation. PMID: 22294699
    7. It plays a critical role in axonal maturation and myelination. (review) PMID: 21077326
    8. The use of proteolysis to study the structure of nardilysin. PMID: 12054470
    9. Studies extend the range of potential substrates for nardilysin and further substantiate that nardilysin is a true peptidase. PMID: 12590613
    10. role for nardilysin in oocyte meiosis through its dynamic translocation from cytosol to nucleus, and then to the spindle apparatus PMID: 15629122
    11. NRDc regulates axonal maturation and myelination in the nervous system, in part, through the modulation of NRG1 shedding PMID: 19935654
    12. The acidic stretch of nardilysin, expressed as a fusion protein with glutathione S-transferase and compared to the native enzyme with respect to spermine binding, functions as an autonomous domain. PMID: 11478915

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  • 蛋白家族：
    Peptidase M16 family
  • 数据库链接：

    KEGG: mmu:230598

    STRING: 10090.ENSMUSP00000068328

    UniGene: Mm.274950

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