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  4. Recombinant Mouse Na (+)/H (+) exchange regulatory cofactor NHE-RF2 (Slc9a3r2)

Recombinant Mouse Na (+)/H (+) exchange regulatory cofactor NHE-RF2 (Slc9a3r2)

  • 中文名称：
    小鼠Slc9a3r2重组蛋白
  • 货号：
    CSB-YP867474MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Slc9a3r2重组蛋白
  • 货号：
    CSB-EP867474MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Slc9a3r2重组蛋白
  • 货号：
    CSB-EP867474MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Slc9a3r2重组蛋白
  • 货号：
    CSB-BP867474MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Slc9a3r2重组蛋白
  • 货号：
    CSB-MP867474MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Slc9a3r2
  • Uniprot No.：
    Q9JHL1
  • 别名：
    Slc9a3r2; Nherf2Na(+)/H(+) exchange regulatory cofactor NHE-RF2; NHERF-2; NHE3 kinase A regulatory protein E3KARP; Octs2; SRY-interacting protein 1; SIP-1; Sodium-hydrogen exchanger regulatory factor 2; Solute carrier family 9 isoform A3 regulatory factor 2; Tyrosine kinase activator protein 1; TKA-1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-337
  • 氨基酸序列
    MAAPESLRPR LCRLVRGEQG YGFHLHGEKG RRGQFIRRVE PGSPAEAAAL RAGDRLVEVN GVNVEGETHH QVVQRIKAVE GQTQLLVVDK ETDEELCRRQ LTCTEEMAHR GLPPAHNPWE PKPDWACSGS LGSDTGQKDV NGPPRELRPR LCHLRRGPQG YGFNLHSDKS RPGQYIRSVD PGSPASHSGL RAQDRLIEVN GQNVEGLRHA EVVARIKAQE DEARLLVVDP ETDEHFKRLR VVPTEEHVEG PLPSPVTNGT SPAQLNGGSV CSSRSDLPGS EKDNEDGSTW KRDPFQESGL HLSPTAAEAK EKARATRVNK RAPQMDWNRK REIFSNF
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May also act as scaffold protein in the nucleus.
  • 基因功能参考文献：
    1. LRBA deficiency is associated with a reduced abundance of radixin and Nherf2, two adaptor proteins, which are important for the mechanical stability of the basal taper region of stereocilia. PMID: 28893864
    2. Knockdown of NHERF2 decreased colon cancer progression. NHERF2 deletion attenuated Stat3 activation and CD24 expression in colon cancer cells. PMID: 26867566
    3. NHERF2 is differentially distributed to lipid rafts in brush border membrane fractions of NHE3. PMID: 24297041
    4. involvement of NHERF2 in multiple apical regulatory processes and interactions with luminal contents PMID: 21427361
    5. NHERF2 is necessary for multiple aspects of acute regulation of NHE3 in intact mouse small intestine PMID: 21430287
    6. It was concluded that NHERF2 plays important roles in tethering NHE3 to a position near the terminal web and in second messenger inhibition of NHE3 in a signal- and segment-specific fashion. PMID: 20962002
    7. Lysophosphatidic acid (LPA) is a potent stimulant of NHE3 and fluid absorption in the intestine, signaling through LPA(5). Regulation by LPA(5) depends on its interaction with NHERF2. PMID: 19800338
    8. demonstration of the significance of SGK1 and NHERF2 as TRPV5 modulators which are likely to participate in the regulation of calcium homeostasis by 1,25(OH)2D3 PMID: 15665527
    9. NHERF-2 and mGluR5 exhibit overlapping patterns of expression in mouse brain, where their association prolongs intracellular calcium mobilization by mGluR5 and promotes mGluR5-mediated toxicity. PMID: 16891310
    10. There were no differences in the urinary excretion of protein or low-molecular-weight proteins between wild-type control, NHERF-1 and NHERF-2 deficient mice. PMID: 18256311
    11. CFTR-dependent duodenal bicarbonate-ion secretion in mouse models of NHERF-2 loss of function. PMID: 19221439

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  • 亚细胞定位：
    Endomembrane system; Peripheral membrane protein. Nucleus. Apical cell membrane.
  • 数据库链接：

    KEGG: mmu:65962

    STRING: 10090.ENSMUSP00000002572

    UniGene: Mm.21587

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