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  4. Recombinant Mouse NLR family member X1 (Nlrx1), partial

Recombinant Mouse NLR family member X1 (Nlrx1), partial

  • 中文名称：
    小鼠Nlrx1重组蛋白
  • 货号：
    CSB-YP015878MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Nlrx1重组蛋白
  • 货号：
    CSB-EP015878MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Nlrx1重组蛋白
  • 货号：
    CSB-EP015878MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Nlrx1重组蛋白
  • 货号：
    CSB-BP015878MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Nlrx1重组蛋白
  • 货号：
    CSB-MP015878MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Nlrx1
  • Uniprot No.：
    Q3TL44
  • 别名：
    Nlrx1; NLR family member X1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Participates in antiviral signaling.
  • 基因功能参考文献：
    1. Data suggest that Nucleotide-binding domain and leucine-rich-repeat-containing family member X1 (NLRX1) acts as an important regulator of the cisplatin-elicited ototoxity. PMID: 28287190
    2. NLRX1 function extends to the control of hepatocyte energy metabolism via the restriction of mitochondrial fatty acid-dependent OXPHOS and enhancement of glycolysis. PMID: 29514047
    3. NLRX1 suppresses tumorigenesis and reveals new genetic pathways involved in the pathobiology of histiocytic sarcoma PMID: 27105514
    4. Nlrx1-/- mice exhibited significantly larger brain lesions and increased motor deficits following controlled cortical impact injury PMID: 28993512
    5. role in control of mitochondrial activity and prevention of oxidative stress and apoptosis in tissue injury PMID: 28626071
    6. this in vitro studies show that NLRX1-deficient T cells have a greater ability to differentiate into an inflammatory phenotype and possess greater proliferation rates PMID: 28159898
    7. NLRX1 diminishes Tumor Necrosis Factor-alpha-induced activation of both Akt- and NF-kappaB-dependent pathways. Since Akt was shown to be essential for Tumor Necrosis Factor-alpha-mediated activation of NF-kappaB it is likely that the primary effect of NLRX1 is at the level of C-Akt proein signaling. PMID: 26971996
    8. NLRX1 attenuated Apc(min/+) colon tumorigenesis, cellular proliferation, NF-KappaB, mitogen-activated protein kinase, signal transducer and activator of transcription 3 activation, and interleukin 6 levels. PMID: 26971998
    9. NLRX1 may relate to hair cell maturity, hearing formation and maintenance, and promote hair cell apoptosis through JNK pathway PMID: 26836140
    10. The regulatory role of NLRX1 in mechanisms of host tolerance employed by macrophages to respond to Helicobacter pylori infection.NLRX1 modulates innate immune responses to Helicobacter pylori infection. PMID: 26367386
    11. Nlrx1 may play an important role in neurodegenerative diseases, where necrosis is a prominent factor. PMID: 25540124
    12. These data support a model in which CS-dependent NLRX1 inhibition facilitates MAVS/RHL activation and subsequent inflammation, remodeling, protease, cell death, and inflammasome responses. PMID: 25938787
    13. The unique capacity of NLRX1 to regulate the cellular sensitivity toward intrinsic versus extrinsic apoptotic signals suggests a critical role for this protein in numerous physiological processes and pathological conditions. PMID: 24867956
    14. NLRX1 enhances macrophage antiviral immunity by interacting with influenza virus PB1-F2 protein, as well as preventing mitochondrial-induced apoptosis PMID: 24799673
    15. Analysis of the macrophage and microglial populations indicates that NLRX1 reduces activation during both active and passive EAE models PMID: 24366868
    16. does not participate in the negative regulation of MAVS-dependent antiviral responses PMID: 23212541
    17. NLRX1 attenuated IFN-I production & promoted autophagy during viral infection. NLRX1 interacts with TUFM. PMID: 22749352
    18. study identifies a previously unrecognized role for NLRX1 in the negative regulation of TLR-induced NF-kappaB activation by dynamically interacting with TRAF6 and the IKK complex PMID: 21703539
    19. NLRX1 interacts with TRAF6 and inhibits NF-kappaB activation PMID: 21703540
    20. the presence of NLRX1 is required for optimal chlamydial growth and reactive oxygen species production PMID: 20959452

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  • 亚细胞定位：
    Mitochondrion outer membrane.
  • 蛋白家族：
    NLRP family
  • 数据库链接：

    KEGG: mmu:270151

    STRING: 10090.ENSMUSP00000034621

    UniGene: Mm.3957

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