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  4. Recombinant Mouse NACHT, LRR and PYD domains-containing protein 6 (Nlrp6), partial

Recombinant Mouse NACHT, LRR and PYD domains-containing protein 6 (Nlrp6), partial

  • 中文名称：
    小鼠Nlrp6重组蛋白
  • 货号：
    CSB-YP838689MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Nlrp6重组蛋白
  • 货号：
    CSB-EP838689MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Nlrp6重组蛋白
  • 货号：
    CSB-EP838689MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Nlrp6重组蛋白
  • 货号：
    CSB-BP838689MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Nlrp6重组蛋白
  • 货号：
    CSB-MP838689MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Nlrp6
  • Uniprot No.：
    Q91WS2
  • 别名：
    Nlrp6; Nalp6; Navr; Pypaf5; NACHT; LRR and PYD domains-containing protein 6; Angiotensin II/vasopressin receptor; Non-angiotensin-vasopressin receptor; Non-AVR; PYRIN-containing APAF1-like protein 5-like
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    As the sensor component of the NLRP6 inflammasome, plays a crucial role in innate immunity and inflammation. In response to yet unidentified signals, initiates the formation of the inflammasome polymeric complex, made of NLRP6, PYCARD and CASP1 (or possibly CASP4/CASP11). Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. The precise NLRP6 activation stimulus has not been identified yet. Essential for gut mucosal self-renewal and proliferation. Maintains intestinal homeostasis and a healthy intestinal microbiota. This function is, at least partially, mediated by IL18, and not IL1B, produced by nonhematopoietic cells. Influences intestinal barrier function and microbial homeostasis through the regulation of goblet cell mucus secretion. Acts by promoting autophagy in goblet cells, an essential step for mucus granule exocytosis. Its role in goblet cell physiology is inflammasome-dependent, but IL1B- and IL18-independent. During systemic bacterial infections, may negatively regulate inflammatory signaling and inhibit the influx of monocytes and neutrophils to the circulation and to the peritoneum. May promote peripheral nerve recovery following injury via an inflammasome-independent mechanism.
  • 基因功能参考文献：
    1. Clostridium butyricum may exert a beneficial action on visceral hypersensitivity of irritable bowel syndrome (IBS) by inhibiting low grade inflammation of colonic mucous through its action on nod-like receptor pyrin domain-containing protein 6 (NLRP6). PMID: 29329362
    2. NLRP6 is important for suppressing the development of spontaneous colitis in the Il10 (-/-) inflammatory bowel disease model and NLRP6 deficiency results in the enrichment of Akkermansia muciniphila. PMID: 28445725
    3. these data reveal a previously unappreciated role for NLRP6 in inflammatory monocytes, which are recruited after dextran sodium sulfate-induced intestinal injury to promote barrier function and limit bacteria-driven inflammation PMID: 27353251
    4. this study shows that Nlrp6-dependent Inflammasomes do not shape the commensal gut microbiota composition PMID: 28801232
    5. this review discuss recent findings related to NLRP6 activity, while highlighting outstanding questions and future perspectives in elucidating its roles in health and disease PMID: 28214100
    6. Study identified a set of microbiota-modulated metabolites whose integrative activity drives NLRP6 inflammasome activation and downstream epithelial IL-18-induced anti-microbial peptide secretion, thereby providing favorable conditions for WT microbiota colonization. PMID: 26638072
    7. Nlrp6 contributes to recovery from peripheral nerve injury by dampening inflammatory responses independently of IL-1beta and inflammasomes PMID: 26253422
    8. These data demonstrate that Nlrp6 functions with Dhx15 as a viral RNA sensor to induce IFN-stimulated genes , and this effect is especially important in the intestinal tract. PMID: 26494172
    9. Study demonstrates that NLRP6 is important in maintaining autophagy in the intestinal epithelium, a process previously shown to be critically important in intestinal granule exocytosis pathway. PMID: 24581500
    10. Exposure of mice to stress inhibits NLRP6 and alters the composition of the gut microbiota, leading to intestinal inflammation. PMID: 23470617
    11. Studies identify AVR/NAVR as key receptors involved in blood pressure regulation and sex-specific modulation of renal water homeostasis, cognitive function, and anxiety-like behavior. PMID: 20923861
    12. AVR is distinct from Nalp6/PYPAF5 based on different mRNA and protein sizes, subcellular localization, and tissue-specific expression patterns. PMID: 18413781
    13. The dual AngII/AVP receptor gene N119S/C163R variant exhibits sodium-induced dysfunction and cosegregates with salt-sensitive hypertension in the Dahl salt-sensitive hypertensive rat model. PMID: 11984003
    14. This publication deals with the rat ortholog of the mouse Nlrp6 gene. PMID: 7489366
    15. results reveal NLRP6 as a negative regulator of inflammatory signalling, and demonstrate a role for this NLR in impeding clearance of both Gram-positive and -negative bacterial pathogens PMID: 22763455
    16. NLRp6 function in maintaining intestinal homeostasis to prevent the development of aberrant inflammation and tumor development within the colon. PMID: 21543645
    17. Data show that absence of NLRP6 accelerated colitis-associated tumor growth in mice. PMID: 21593405
    18. Study shows that deficiency of NLRP6 in mouse colonic epithelial cells reduces IL-18 levels & altered fecal microbiota with expanded bacterial phyla Prevotellaceae & TM7; this altered microbiota is associated with a colitogenic phenotype. PMID: 21565393

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  • 亚细胞定位：
    [Isoform 1]: Cytoplasm. Inflammasome. Cell membrane. Nucleus membrane.; [Isoform 2]: Cytoplasm. Cell membrane.
  • 蛋白家族：
    NLRP family
  • 组织特异性：
    Highly expressed in the gastrointestinal tract, predominantly in colonic myofibroblasts and in colonic epithelial and endothelial cells. Within the intestinal mucosa, highly expressed by goblet cells. Also expressed in hepatocytes and in immune cells, inc
  • 数据库链接：

    KEGG: mmu:101613

    STRING: 10090.ENSMUSP00000101660

    UniGene: Mm.386833

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