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  4. Recombinant Mouse NACHT, LRR and PYD domains-containing protein 5 (Nlrp5), partial

Recombinant Mouse NACHT, LRR and PYD domains-containing protein 5 (Nlrp5), partial

  • 中文名称：
    小鼠Nlrp5重组蛋白
  • 货号：
    CSB-YP874177MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Nlrp5重组蛋白
  • 货号：
    CSB-EP874177MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Nlrp5重组蛋白
  • 货号：
    CSB-EP874177MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Nlrp5重组蛋白
  • 货号：
    CSB-BP874177MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Nlrp5重组蛋白
  • 货号：
    CSB-MP874177MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Nlrp5
  • Uniprot No.：
    Q9R1M5
  • 别名：
    Nlrp5; Mater; Nalp5NACHT; LRR and PYD domains-containing protein 5; Maternal antigen that embryos require; Mater protein; Ooplasm-specific protein 1; OP1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics. Required for the formation of F-actin cytoplasmic lattices (CPL) in oocytes, which in turn are responsible for symmetric division of zygotes via the regulation of mitotic spindle formation and positioning. Required for the localization of cortical granules to the cortex of oocytes, via association with the cortical actin scaffold. Required for cortical actin clearance prior to oocyte exocytosis and prevention of polyspermy. Involved in regulating post-fertilization Ca(2+) release and endoplasmic reticulum storage (ER) storage via regulation of cellular localization. May be involved in the localization of mitochondria to the cytoplasm and perinuclear region in oocytes and early stage embryos, independent of its role in CPL formation.
  • 基因功能参考文献：
    1. The expression of Mater protein is decreased in mature oocytes from old versus young mice. PMID: 26769260
    2. MATER is part of the subcortical maternal complex (SCMC). SCMC is required for formation of the cytoplasmic F-actin meshwork that controls the central position of the spindle and ensures symmetric division. PMID: 25208553
    3. MATER is required for endoplasmic reticulum distribution and Ca2+ homeostasis in oocytes, likely due to defects in lattice-mediated ER positioning and/or redistribution. PMID: 24374158
    4. It was concluded that lack of Nlrp5 in oocytes triggers premature activation of the mitochondrial pool, causing mitochondrial damage that cannot be rescued by inactivation of Bax. PMID: 22357545
    5. Transgenic expression of MATER induces antigen-specific tolerance with a significant reduction in ovarian autoimmunity. PMID: 21447630
    6. MATER co-localizes with PADI6 at the oocyte cytoplasmic lattices. PMID: 20830304
    7. Mater gene transcription and protein translation are active during oogenesis, but appear inactive during early embryogenesis PMID: 14670992
    8. MATER and three similar genes are localized to mouse chromosome 7 PMID: 15474461
    9. The plasticity of the FILIA-MATER complex localization may reflect the regulative nature of preimplantation mouse development. PMID: 18057100
    10. Results describe a subcortical maternal complex, containing Mater, Floped, TLE6, and Filia, that is essential for preimplantation mouse embryogenesis. PMID: 18804437
    11. The highest Mater mRNA levels were detected in oocytes in the pre-antral follicle stage. PMID: 19553355

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  • 亚细胞定位：
    Cytoplasmic vesicle, secretory vesicle, Cortical granule. Mitochondrion. Nucleus, nucleolus. Cytoplasm. Golgi apparatus.
  • 数据库链接：

    KEGG: mmu:23968

    STRING: 10090.ENSMUSP00000015866

    UniGene: Mm.333653

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