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  4. Recombinant Mouse N (G),N (G)-dimethylarginine dimethylaminohydrolase 1 (Ddah1)

Recombinant Mouse N (G),N (G)-dimethylarginine dimethylaminohydrolase 1 (Ddah1)

  • 中文名称：
    Recombinant Mouse N(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Ddah1)
  • 货号：
    CSB-YP871913MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse N(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Ddah1)
  • 货号：
    CSB-EP871913MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse N(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Ddah1)
  • 货号：
    CSB-EP871913MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse N(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Ddah1)
  • 货号：
    CSB-BP871913MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse N(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Ddah1)
  • 货号：
    CSB-MP871913MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Ddah1
  • Uniprot No.：
    Q9CWS0
  • 别名：
    Ddah1N(G),N(G)-dimethylarginine dimethylaminohydrolase 1; DDAH-1; Dimethylarginine dimethylaminohydrolase 1; EC 3.5.3.18; DDAHI; Dimethylargininase-1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-285
  • 氨基酸序列
    AGLGHPSAF GRATHAVVRA PPESLCRHAL RRSQGEEVDF ARAERQHELY VGVLGSKLGL QVVQLPADES LPDCVFVEDV AVVCEETALI TRPGAPSRRK EVDMMKEALE KLQLNIVEMK DENATLDGGD VLFTGREFFV GLSKRTNQRG AEILADTFKD YAVSTVPVAD SLHLKSFCSM AGPNLIAIGS SESAQKALKI MQQMSDHRYD KLTVPDDMAA NCIYLNIPSK GHVLLHRTPE EYPESAKVYE KLKDHLLIPV SNSEMEKVDG LLTCCSVFIN KKIDS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.
  • 基因功能参考文献：
    1. DDAH1 in cardiomyocytes plays a vital role in attenuating left ventricular remodeling after acute myocardial infarction by regulating intracellular ROS levels and apoptosis sensitivity via a SOD2-dependent pathway. PMID: 29892894
    2. Cardiomyocyte DDAH1 activity is dispensable for cardiac function under basal conditions, but plays an important role in attenuating cardiac hypertrophy and ventricular remodeling under stress conditions, possibly through locally confined regulation of subcellular ADMA and NO signaling. PMID: 28819685
    3. the ADMA/DDAH1 pathway has a marked effect on hepatic lipogenesis and steatosis induced by HFD feeding. Our findings suggest that strategies to increase DDAH1 activity in hepatocytes may provide a novel approach to attenuate NAFLD development. PMID: 27565538
    4. A time-dependent decrease in serum and tissue ADMA and increase in mRNA expression of DDAH-1 and PRMT-1 as well as higher rates of mRNA expression of CAT-1 and lower rates of CAT-2A and CAT-2B were found after 8-week MCD diet. PMID: 27357826
    5. our results suggest that DDAH1 not only acts as an enzyme degrading ADMA but also controls cellular oxidative stress and apoptosis via a miR-21-dependent pathway. PMID: 26806551
    6. In mild CKD, dysregulation of the ADMA/DDAH pathway in adipose tissue triggers lipodystrophy-like phenotype changes, including ectopic fat depositions. PMID: 26516203
    7. transgenic mice display attenuated cigarette smoke-induced lung inflammation PMID: 25913572
    8. Endothelial deletion of DDAH1 profoundly impairs the angiogenic capacity of endothelial cells. PMID: 25910799
    9. Our findings suggest that decreased expression of DDAH1 and DDAH2 in the lungs may contribute to allergic asthma and overexpression of DDAH1 attenuates allergen-induced airway inflammation through modulation of Th2 responses. PMID: 24465497
    10. Overexpression of the ADMA degrading enzyme, DDAH1, did not ameliorate atherosclerosis in ApoE-deficient subtotally nephrectomized mice. PMID: 24690995
    11. DDAH1 deficiency attenuates endothelial cell cycle progression and angiogenesis. PMID: 24260221
    12. DDAH1 overexpression selectively decreased the sustained phase of hypoxic pulmonary vasoconstriction, partly via activation of the NO-cGMP pathway. PMID: 23642043
    13. Pharmacological and genetic reduction of DDAH1 activity is protective against the vascular changes observed during endotoxic shock. PMID: 22995517
    14. Data show that DDAH inhibition reduces fibroblast-induced collagen deposition in an ADMA-independent manner and reduces abnormal epithelial proliferation in an ADMA-dependent manner. PMID: 21677199
    15. Indicate that DDAH1 is required for metabolizing asymmetrical dimethylarginine and N(omega)-monomethyl-L-arginine. PMID: 21493890
    16. DDAH1 exerts a unique role in activating Akt that affects endothelial function independently of degrading endogenous nitirc oxide synthase inhibitors. PMID: 21212404
    17. overexpression of DDAH1 reduces plaque formation in ApoE(-/-) mice by lowering ADMA PMID: 20348244
    18. Dimethylarginine dimethylaminohydrolase-1 transgenic mice are not protected from ischemic stroke PMID: 19809508
    19. Overexpression of DDAH-1 increases basal levels of vascular NO and protects against ADMA-induced endothelial dysfunction in the cerebral circulation. PMID: 18063827
    20. Report tissue-specific downregulation of DDAH1 in hyperhomocysteinemia. PMID: 18567702
    21. Results show that asymmetric methylarginine increases pulmonary endothelial permeability, and that its effects on permeability, Rac1 activation and VASP phosphorylation are prevented by overexpression of active DDAHI and DDAHII. PMID: 18923147
    22. DDAH1 is highly expressed in vascular endothelium and that endothelial DDAH1 plays an important role in regulating blood pressure PMID: 19917889

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  • 蛋白家族：
    DDAH family
  • 组织特异性：
    Detected in skeletal muscle, lung, heart and brain (at protein level). Detected in liver, kidney and lung.
  • 数据库链接：

    KEGG: mmu:69219

    STRING: 10090.ENSMUSP00000029845

    UniGene: Mm.234247

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