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  4. Recombinant Mouse Myosin-9 (Myh9), partial

Recombinant Mouse Myosin-9 (Myh9), partial

  • 中文名称：
    小鼠Myh9重组蛋白
  • 货号：
    CSB-YP845003MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Myh9重组蛋白
  • 货号：
    CSB-EP845003MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Myh9重组蛋白
  • 货号：
    CSB-EP845003MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Myh9重组蛋白
  • 货号：
    CSB-BP845003MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Myh9重组蛋白
  • 货号：
    CSB-MP845003MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Myh9
  • Uniprot No.：
    Q8VDD5
  • 别名：
    Myh9; Myosin-9; Cellular myosin heavy chain; type A; Myosin heavy chain 9; Myosin heavy chain; non-muscle IIa; Non-muscle myosin heavy chain A; NMMHC-A; Non-muscle myosin heavy chain IIa; NMMHC II-a; NMMHC-IIA
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis. Promotes cell motility in conjunction with S100A4. During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10.
  • 基因功能参考文献：
    1. NMIIa and actin filaments concentrate around lipid droplets (LDs), and form transient foci between dissociating LDs. NMIIa depletion results in decreased LD dissociations, enlarged LDs, decreased hydrolysis and increased storage of triglycerides. PMID: 28361956
    2. data therefore reveal a role for NMIIA and NMIIB as negative regulators of proliferation in the mammary epithelium. PMID: 28821574
    3. Fluorescence resonance energy transfer experiments showed that FliI-NMMIIA interactions require Ca(2+) influx. We conclude that Ca(2+) influx through the TRPV4 channel regulates FliI-NMMIIA interaction, which in turn enables generation of the cell extensions essential for collagen remodeling PMID: 28526784
    4. APPL1 enhances glucose uptake by modulating the activation and localization of PKCzeta, as well as its functional interaction with both PP2A and myosin IIa. PMID: 27478065
    5. Data show that deletion of myosin heavy chain II-A (Myh9)/myosin heavy chain II-B (Myh10) caused severe hydroureter/hydronephrosis at birth. PMID: 28478097
    6. our data indicated that PGDHC is a Pg-derived, cell-permeable ceramide that possesses a unique property of promoting osteoclastogenesis via interaction with Myh9 which, in turn, activates a Rac1/DC-STAMP pathway for upregulation of osteoclast cell fusion. PMID: 28153611
    7. Conditional deletion of nonmuscle myosin II-A in mouse tongue epithelium results in squamous cell carcinoma PMID: 26369831
    8. Inhibition of NMMHC IIA impedes TF expression and venous thrombosis via Akt/GSK3beta-NF-kappaB signalling pathways in the endothelium both in vitro and in vivo. PMID: 25881103
    9. Myh9 mediates colitis-induced epithelium injury by restricting Lgr5+ stem cells PMID: 25968904
    10. Mst1 regulates Myosin IIa dynamics to organize high and low affinity LFA-1 to the anterior and posterior membrane during T cell migration. PMID: 25133611
    11. regulates morphogenesis of immature nephrons PMID: 25168025
    12. DDR1 malfunction causes outer hair cells deformation and the separation of the lateral wall, the location of the cellular motor responsible for the electromotile property, explicitly in those regions showing DDR1 and NM-IIA co-localization. PMID: 25307162
    13. A new role for Arl13b in actin cytoskeleton remodeling through the interaction with Myh9. PMID: 24777479
    14. The distribution of organelles within platelets critically depends on a homogeneous organelle distribution within megakaryocytes and preplatelet fragments, which requires myosin IIA. PMID: 24243973
    15. While MyoIIA activity is required for F-actin localization at the plasma membrane, it alone is insufficient to localize F-actin to the plasma membrane. PMID: 24374234
    16. The Myh9 R702C missense mutation results in the MYH9 disorder phenotype. PMID: 23976996
    17. Podocyte-specific deletion of Myh9 results in a variable susceptibility to glomerulosclerosis in response to different models of glomerular injury. PMID: 23874454
    18. Seven of top hits-including Myh9, which encodes nonmuscle myosin IIa-have not been linked to tumor development, yet tissue-specific Myh9 RNAi and Myh9 knockout trigger invasive squamous cell carcinomas formation on tumor-susceptible backgrounds. PMID: 24436421
    19. NMHC IIA may play critical roles in the early trophoblast-derived ectoplacental cone and extraembryonic ectoderm in Keratin 5-Cre transgenic mice. PMID: 23911870
    20. study concludes that cell adhesion to collagen presented on beads activates Ca(2 ) entry and promotes the formation of phagosomes enriched with NMMIIA and gelsolin PMID: 23325791
    21. MIIA is required for efficient cell migration in restricted environments as well as for adhesion maturation. PMID: 22328520
    22. Myosin IIA inhibition also significantly reduces phosphorylation of the mechanosensing protein CasL (Crk-associated substrate the lymphocyte type), raising the possibility of a direct mechanical mechanism of signal modulation involving CasL. PMID: 22347397
    23. Mutations in MYH9 is associated with hematologic, eye, and kidney abnormalities PMID: 21908426
    24. Myh9 podocyte deletion in C57BL/6 mice results in susceptibility to experimental doxorubicin hydrochloride glomerulopathy PMID: 21402784
    25. myosin IIA and IIB are differentially expressed and localized and have clearly different functions in hepatic stellate cells PMID: 20932596
    26. thrombocytopenia in Myh9Delta mice results from defective development of megakaryocyte size, impaired proplatelet formation and increased cell death PMID: 20695978
    27. mutated non-muscle myosin IIA can lead to thrombocytopenia in mice and humans PMID: 20723023
    28. Loss of myosin II, VI or VIIa function had no significant effects on rates of endocytic vesicle movement in bone marrow-derived dendritic cells.[myo2a or Non muscle myosin II] PMID: 17615572
    29. Myosin IIA optimizes lymphocyte crawling efficiency in the many environments T cells must pass through during their trafficking. PMID: 20835229
    30. Results highlight the functions of the N-terminal motor and C-terminal rod domains of NM II and their different roles in cell-cell and cell-matrix adhesion. PMID: 20679233
    31. Data suggest that NMIIA creates a coherent actin network through the formation of circumferential actin bundles that mechanically link elements of the peripheral actin cytoskeleton where much of the force is generated during spreading. PMID: 20067993
    32. These data suggest that myosin IIA plays a role in insulin-stimulated docking of glucose transporter 4 storage vesicles to the plasma membrane in 3T3-L1 adipocytes through SNARE complex formation. PMID: 19968963
    33. downregulated expression in T cells following treatment with bis(tri-n-butylin)oxide (TBTO), an immunotoxic organotin PMID: 19552622
    34. Cloning of the mouse Myh9 cDNA and the temporal onset and spatial distribution of Myh9 expression in the inner ear of the developing fetus, the neonate, and the adult are described. PMID: 15079858
    35. Expression of Myh9 in the mice cochlea: localization within the stereocilia PMID: 16862555
    36. Myosin IIA negatively regulates cell migration and maintains a balance between the actomyosin and microtubule systems by regulating microtubule dynamics. PMID: 17310241
    37. Pairwise and multilocus haplotype analyses identified linkage disequilibrium between polymorphism alleles at the MYH9 locus and the disease. PMID: 17337617
    38. interference with the putative Rho-ROCK-myosin-IIA pathway selectively decreases the number of circulating platelets PMID: 17392504
    39. Megakaryocyte-restricted MYH9 inactivation dramatically affects hemostasis while preserving platelet aggregation and secretion. PMID: 17664350
    40. Myh9 haploinsufficiency does not a pathogenic factor in the etiology of auditory dysfunction. PMID: 17914179
    41. Alternative splice variants of MYH9. PMID: 17997715
    42. The presence of NMHC-IIa within heterogeneous areas of the hair cell suggests that it may play different functional roles in these distinct regions. PMID: 18241845
    43. TRPM7 regulates myosin IIA filament stability and localization by phosphorylating a short stretch of amino acids within the alpha-helical tail of the myosin IIA heavy chain PMID: 18394644
    44. Expression of full-length human NMHC-IIA and -IIB in 10 T1/2 cells demonstrated that flectin antibody recognizes both isoforms[NMHC-IIB and NMHC-IIA] PMID: 18697221
    45. MYH9Delta megakaryocytes were unable to form stress fibers upon adhesion to collagen. PMID: 18984861
    46. The response of dorsal root ganglion (DRG) neurons to Semaphorin 3A gradients can be divided into two steps: growth cone collapse and retraction. Collapse is inhibited by overexpression of myosin IIA or growth on high substrate-bound laminin-1. PMID: 19109430
    47. expression of nonmuscle myosin IIA inhibits osteoclast precursor fusion and that a temporary, cathepsin B-mediated decrease in myosin IIA levels triggers precursor fusion during osteoclastogenesis. PMID: 19269977
    48. The collagen receptor DDR1 regulates cell spreading and motility by associating with myosin IIA. PMID: 19401332
    49. myosin II, directly regulates cellular patterning and alignment within the cochlear sensory epithelium PMID: 19439495

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Cytoplasmic vesicle, secretory vesicle, Cortical granule.
  • 蛋白家族：
    TRAFAC class myosin-kinesin ATPase superfamily, Myosin family
  • 数据库链接：

    KEGG: mmu:17886

    STRING: 10090.ENSMUSP00000016771

    UniGene: Mm.29677

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