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  4. Recombinant Mouse Myb-binding protein 1A (Mybbp1a), partial

Recombinant Mouse Myb-binding protein 1A (Mybbp1a), partial

  • 中文名称：
    小鼠Mybbp1a重组蛋白
  • 货号：
    CSB-YP763177MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Mybbp1a重组蛋白
  • 货号：
    CSB-EP763177MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Mybbp1a重组蛋白
  • 货号：
    CSB-EP763177MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Mybbp1a重组蛋白
  • 货号：
    CSB-BP763177MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Mybbp1a重组蛋白
  • 货号：
    CSB-MP763177MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Mybbp1a
  • Uniprot No.：
    Q7TPV4
  • 别名：
    Mybbp1a; P160Myb-binding protein 1A; Myb-binding protein of 160 kDa
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May activate or repress transcription via interactions with sequence specific DNA-binding proteins. Repression may be mediated at least in part by histone deacetylase activity (HDAC activity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2. Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter. Has a role in rRNA biogenesis together with PWP1.
  • 基因功能参考文献：
    1. Mybbp1a is a novel negative regulator of Sirt7. PMID: 24134843
    2. Data show that down-regulation of MYBBP1A decreases the growth rate of wild type mouse embryonic stem cells, embryo fibroblasts (MEFs) and of human HeLa cells, where it also promotes apoptosis. PMID: 23056166
    3. Mybbp1a may play a dual role in the rRNA metabolism, potentially linking and coordinating ribosomal DNA transcription and pre-rRNA processing to allow for the efficient synthesis of ribosomes. PMID: 22645127
    4. Myb-binding protein 1a was identified as a novel negative regulator of muscle-specific gene expression and myoblast differentiation. PMID: 22333916
    5. Myb-binding protein p160 is a novel target of the von Hippel-Lindau tumor suppressor. PMID: 21386990
    6. Ipr1 might be involved in apoptosis pathway via MYBBP1A. PMID: 20221700
    7. Myb-binding protein 1a augments AhR-dependent gene expression PMID: 11956195
    8. Mybbp1a is a nucleocytoplasmic shuttling protein involved in nuclear import and export via CRM1-dependent and -independent pathways. PMID: 12941609
    9. These data show that p160 is a novel regulator of Prep1-Pbx1 transcriptional activity. PMID: 17875935
    10. SRC-3 alone of the p160 coactivators enhanced CAR transactivation in hepatic cells without PB treatment. PMID: 17950690
    11. Mybbp1a may connect the ribosome biogenesis and the Myb-dependent transcription, which controls cell cycle progression and proliferation. PMID: 18173745
    12. Results suggest that Prep1 controls insulin sensitivity through the p160-GLUT4 pathway. PMID: 18644868

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  • 亚细胞定位：
    Nucleus. Nucleus, nucleolus. Cytoplasm.
  • 组织特异性：
    Ubiquitously expressed.
  • 数据库链接：

    KEGG: mmu:18432

    STRING: 10090.ENSMUSP00000044827

    UniGene: Mm.147946

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