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  4. Recombinant Mouse Multiple PDZ domain protein (Mpdz), partial

Recombinant Mouse Multiple PDZ domain protein (Mpdz), partial

  • 中文名称：
    小鼠Mpdz重组蛋白
  • 货号：
    CSB-YP014745MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Mpdz重组蛋白
  • 货号：
    CSB-EP014745MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Mpdz重组蛋白
  • 货号：
    CSB-EP014745MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Mpdz重组蛋白
  • 货号：
    CSB-BP014745MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Mpdz重组蛋白
  • 货号：
    CSB-MP014745MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Mpdz
  • Uniprot No.：
    Q8VBX6
  • 别名：
    Mpdz; Mupp1; Multiple PDZ domain protein; Multi-PDZ domain protein 1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses. Promotes clustering of HT2RC at the cell surface.
  • 基因功能参考文献：
    1. This work provides a relevant hydrocephalus mouse model and demonstrates that Mpdz is essential to maintain integrity of the ependyma. PMID: 28500065
    2. Variants of the multiple PDZ domain gene Mpdz may contribute to the observed inter-strain variability in opioid tolerance and opioid-induced hyperalgesia by virtue of changes in the level of their expression. PMID: 27129385
    3. MUPP1-PDZ4 domain contained three alpha-helices and six beta-strands in the core. The GLGI motif, L562/A564 on the beta-strand B, and H605/V608/L612 on the alpha-helix B formed a PDZ binding pocket which could bind to the C-terminal of the binding partners. PMID: 25662616
    4. Increased MPDZ expression decreased the severity of ethanol withdrawal, while decreased MPDZ expression increased ethanol withdrawal severity. Decreased MPDZ expression was associated with increased voluntary ethanol consumption. PMID: 24118405
    5. neurexin 1 interaction with multi-PDZ domain protein MUPP1 PMID: 25036961
    6. Our results confirm that Mpdz is a quantitative trait gene for alcohol withdrawal and demonstrate that its expression in the caudolateral substantia nigra pars reticulata is crucially involved in risk for alcohol withdrawal. PMID: 25109596
    7. regulates odor responses and activation kinetics of olfactory sensory neurons PMID: 24652834
    8. despite their terminal sequence diversity all three GABA transporter PDZ motifs interacted with MUPP1 domain 7 PMID: 25305483
    9. Cadm1 specifically interacts with Mupp1, and may form a ternary complex with Mupp1-GABBR2 in the cerebellum. PMID: 22994563
    10. CaMKIIalpha interacts with MUPP1 in spermatozoa to prevents spontaneous acrosomal exocytosis. PMID: 19934217
    11. 5-HT2C R interaction with MUPP1 is dynamically regulated by phosphorylation at Ser458 PMID: 12682077
    12. MUPP1 protein expression is co-localized with 5-HT(2A) or 5-HT(2C) receptor expression in all regions of the mouse brain, including the choroid plexus where 5-HT(2C) receptors are highly enriched. PMID: 12706259
    13. Mpdz may have pleiotropic effects on multiple seizure phenotypes, including seizures associated with withdrawal from two classes of central nervous system (CNS) depressants and sensitivity to specific chemiconvulsants. PMID: 14960011
    14. This study identified an addiction-relevant quantitative trait gene, Mpdz. and provide a framework to define the protein interactions and neural circuit by which this multiple PDZ domain protein affects drug dependence, withdrawal and relapse. PMID: 15208631
    15. this scaffolding protein, which comprises 13 different PDZ domains, is expressed in mouse testis. Immunoreactivity is concentrated within the acrosomal region of round as well as elongated mouse spermatozoa. PMID: 16452527
    16. Data show that MUPP1 interacts with angiomotin (Amot), JEAP/Amot-like 1 and MASCOT/Amot-like 2, and that all the Amot/JEAP family proteins also interacted with Patj, a close relative of MUPP1. PMID: 17397395
    17. This evidence points to a role of MUPP1 as a membrane raft-associated molecular organizer, suggesting that mammalian spermatozoa may use a scaffolding protein and membrane subdomains to organize components involved in the process of acrosomal exocytosis. PMID: 17894389
    18. Linear and cyclic peptide ligands for PDZ10 of the multi-PDZ domain protein MUPP1. PMID: 17939682
    19. These data suggest that allelic variation in Mpdz, or a linked gene, influences SB242084- and baclofen-enhanced convulsions. PMID: 18262506
    20. MUPP1 contributes to the maintenance of a tight epithelium in the medulla of the kidney under hypertonic stress by correctly localizing Cldn4 to the tight junctions PMID: 18840681
    21. These results demonstrate MUPP1 at O/A gap junctions and Cx47-dependent targeting of connexins to the plasma membranes of oligodendrocyte somata. PMID: 18973575
    22. Mpdz gene variations are known contributors of acute alcohol withdrawal severity and seizures in mice. PMID: 19175764
    23. We have therefore elucidated the first building blocks of the putative 'olfactosome', brought together by the scaffolding protein MUPP1, a possible central nucleator of the olfactory response PMID: 19909339

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  • 亚细胞定位：
    Cell membrane; Peripheral membrane protein; Cytoplasmic side. Apical cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse, postsynaptic density. Cell projection, dendrite. Cell junction, tight junction. Cell junction, synapse. Cell junction, synapse, synaptosome.
  • 组织特异性：
    In the brain, it is strongly expressed in the choroid plexus. Within the hippocampal formation, strongest expression was seen in the soma of CA1-4 pyramidal cells. Expressed in most neocortical regions with the strongest expression in piriform cortex and
  • 数据库链接：

    KEGG: mmu:17475

    STRING: 10090.ENSMUSP00000099894

    UniGene: Mm.153039

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