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  4. Recombinant Mouse Multidrug resistance protein 1B (Abcb1b), partial

Recombinant Mouse Multidrug resistance protein 1B (Abcb1b), partial

  • 中文名称：
    Recombinant Mouse Multidrug resistance protein 1B(Abcb1b) ,partial
  • 货号：
    CSB-YP001046MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Multidrug resistance protein 1B(Abcb1b) ,partial
  • 货号：
    CSB-EP001046MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Multidrug resistance protein 1B(Abcb1b) ,partial
  • 货号：
    CSB-EP001046MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Multidrug resistance protein 1B(Abcb1b) ,partial
  • 货号：
    CSB-BP001046MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Multidrug resistance protein 1B(Abcb1b) ,partial
  • 货号：
    CSB-MP001046MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Abcb1b
  • Uniprot No.：
    P06795
  • 别名：
    Abcb1b; Abcb1; Mdr1; Mdr1b; Pgy1; Pgy1-1ATP-dependent translocase ABCB1; ATP-binding cassette sub-family B member 1B; Multidrug resistance protein 1B; EC 7.6.2.2; P-glycoprotein 1; Phospholipid transporter ABCB1; EC 7.6.2.1; CD antigen CD243
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Translocates drugs and phospholipids across the membrane. Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins. Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
  • 基因功能参考文献：
    1. this study shows that MDR1 deficiency impairs mitochondrial homeostasis and promotes intestinal inflammation PMID: 28401939
    2. A panel of 18 P-gp substrates were administered into the airways of an isolated perfused mouse lung (IPML) model derived from Mdr1a/Mdr1b knockout mice. Parallel intestinal absorption studies were performed. Lung P-gp can affect the pulmonary kinetics of a subset of P-gp substrates. PMID: 28702798
    3. Data suggest that the overexpression of P-gp in neoplastic cells may be associated with alterations in O-glycosylated cell surface proteins, including mucins, and this alteration may be responsible for the reduced cell sensitivity to the O-glycosylation inhibitor GalNAc-alpha-O-benzyl. PMID: 28671633
    4. We conclude that mdr1b and bcrp are essential to ovarian protection from chemotoxicity and may have an important physiological role in the ovary. PMID: 28216407
    5. Molecular Dynamics simulations and docking of drugs performed for P-gp (P-gp, multi-drug resistance protein, MDR1).Drugs with ER < 1 almost do not bind the main binding cavity (MBC) of P-gp. PMID: 27984797
    6. conclusion, MDR1 and BCRP are expressed on apical membranes of the rodent placental SynT-II layer. PMID: 27616577
    7. Mdr1 enforces T Cell homeostasis in the presence of intestinal bile acids. PMID: 29262351
    8. Loss of ABCB1 expression is associated with neonatal hyperbilirubinemia. PMID: 28025333
    9. the high-affinity site of P-glycoprotein is inaccessible because of either a conformational change or binding of detergent at the binding site in a detergent micelle environment; ligands bind to a low-affinity site, resulting in altered modulation of P-gp ATPase activity PMID: 28283574
    10. Data suggest that ATP binding to Abcb1b/P-glycoprotein (Pgp) in liposomes exhibits cooperativity with verapamil (a cardiovascular/antiarrhythmia drug); cooperativity between verapamil and a nonhydrolyzable ATP analog (AMPPNP) leads to distinct global conformational changes in Abcb1b/Pgp. PMID: 27531061
    11. Chrysosplenetin inhibited P-gp activity and reverse the up-regulated P-gp and MDR1 levels induced by artemisinin. PMID: 27931149
    12. Tamsulosin and tolterodine with P-gp gene expression and activity in an enantiomer-specific way. PMID: 27678410
    13. Pgp-coupled ATPase activity kinetics measured with a range of verapamil and digoxin concentrations fit well to a DDI model encompassing non-competitive and competitive inhibition of digoxin by verapamil. PMID: 26823559
    14. Data show that human transgenic mutant huntingtin (mHtt) aggregation might be regulated by multidrug resistance protein 1 (MDR1) which suggests that MDR1 might be a potential therapeutic target for Huntington's disease. PMID: 26586297
    15. In vitro and in vivo downregulation of the ATP binding cassette transporter B1 by the HMG-CoA reductase inhibitor simvastatin PMID: 26319048
    16. Efficient chemoprotection of CDD and MDR1 transduced hematopoietic 32D as well as primary lin(-) cells was proven in the context of Ara-C and anthracycline application PMID: 26651614
    17. Mdr1b participates in the elimination of paraquat from the kidneys and protects against subsequent toxicity. PMID: 25015657
    18. These study data have facilitated understanding of the molecular mechanisms of neurotoxicosis in ABCB1-1Delta mutant mice following exposure to various P-gp substrates. PMID: 25419811
    19. Data indicate that the brain penetration of ABT-888 in both Abcb1a/1b-/- and Abcb1a/1b-/-;Abcg2-/- mice was significantly higher than in wild-type mice. PMID: 24647572
    20. Directed evolution of P-glycoprotein cysteines reveals site-specific, non-conservative substitutions that preserve multidrug resistance. PMID: 24825346
    21. Expression of Abcb1 at the blood-brain and blood-spinal barriers is upregulated by Nrf2. PMID: 24948812
    22. The improved structures of Pgp reveal important implications for polyspecific drug recognition in the form of a high concentration of aromatic residues in the drug translocation pathway that is most conserved among mammalian orthologs. PMID: 24155053
    23. Real-time polymerase chain reaction for ABC transporters demonstrated that Abcb1a, Abcb1b and Abcg2, regarded as stem cell markers, were characteristically expressed in TtT/GF cells but not in Tpit/F1 and LbetaT2 cells. PMID: 23881407
    24. In addition to ABCB1-mediated transport. PMID: 23616082
    25. In single Bcrp1(-/-) mice, brain accumulation of CYT387 was more substantially increased than in Mdr1a/1b(-/-) mice, suggesting that CYT387 is a slightly better substrate of Bcrp1 than of Mdr1a at the blood-brain barrier. PMID: 23827160
    26. In Bcrp1;Mrp2;Mrp3(-/-), but not Bcrp1;Mdr1a/b;Mrp(-/-) mice. PMID: 24334255
    27. Data suggest that neither Mdr1a nor Mdr1b are involved in transepithelial transport of herbicide paraquat; brain-to-plasma partitioning ratios and total brain accumulation of paraquat were same across doses between wildtype Mdr1a/Mdr1b knockout mice. PMID: 24297779
    28. These results indicate that radixin plays an important role in regulating P-glycoprotein localization and P-glycoprotein functional activity at the intestinal membrane. PMID: 23754525
    29. Data indicate that Abcc4 limits the brain penetration of camptothecin analogues and teams up with Abcb1a/b and Abcg2 to form a robust cooperative drug efflux system. PMID: 23461902
    30. Transintestinal cholesterol excretion is regulated by PCSK9/ABCB1/statins. PMID: 23559630
    31. P-glycoprotein (Mdr1a/1b) and breast cancer resistance protein (Bcrp) decrease the uptake of hydrophobic alkyl triphenylphosphonium cations by the brain. PMID: 23454352
    32. Results indicate that the potency and specificity of sildenafil as an inhibitor of ABCB1 and ABCG2 is not sufficient to warrant further clinical testing of this agent in combination with anticancer drugs. PMID: 23422148
    33. Functional regulation of P-glycoprotein at the blood-brain barrier in proton-coupled folate transporter (PCFT) mutant mice. PMID: 23212123
    34. the functioning of ABCB1 as an efflux pump does not depend on actin, which is due to its distribution in both cell surface-localized non-raft membrane areas and lipid raft domains PMID: 23085402
    35. Absence of P-glycoprotein (Pgp) transport of antiepileptic drug mephobarbital at the blood-brain barrier is confirmed in vitro by concentration equilibrium transport assay in cell lines transfected with MDR1. PMID: 22342565
    36. Sodium nitroprusside pretreatment functionally impairs P-gp in the in vitro blood-brain barrier model. PMID: 22864744
    37. Hyperglycemia induced reactive oxygen species and activated PKC in MDCK-II cells, leading to the decrease in P-glycoprotein expression PMID: 22721613
    38. The intracellular accumulation of vemurafenib is significantly restricted because of active efflux by P-gp(ABCB1)and BCRP. PMID: 22454535
    39. Pharmacokinetics of quinacrine efflux from mouse brain via the P-glycoprotein efflux transporter. PMID: 22768295
    40. the effects of P-gp on intestinal injury and repair PMID: 22780103
    41. Both P-gp and Bcrp1 reduce the brain penetration of erlotinib. PMID: 20963470
    42. Data indicate that mdr1ab(-/-) P-glycoprotein (Pgp)-deficient mice showed excess weight, hypertrophy of adipose mass, high insulin and glucose levels in plasma. PMID: 21949682
    43. Data show that NSC73306 demonstrated MDR1-selectivity against all P-gp-expressing cell lines examined. PMID: 21721528
    44. ABCB1 identifies a subpopulation of uveal melanoma cells with high metastatic propensity PMID: 21575142
    45. results give evidence for a functional role of transport mechanisms at the blood-brain barrier, specifically of P-gp, and its subregional distribution. PMID: 21304228
    46. Results suggest that Mdr1a/b plays a role in irinotecan and SN-38 elimination. PMID: 20583968
    47. P-gp affected oral absorption and brain penetration of tandutinib to a greater extent than Bcrp, but Bcrp contribution to systemic clearance of tandutinib was greater than P-gp. PMID: 20670210
    48. The average brain-to-plasma concentration ratio and blood-brain barrier partitioning of levosulpiride were 2.3- and 2.0-fold higher in Abcb1a/1b(-/-) mice than in wild-type mice, respectively. PMID: 20438811
    49. Breast cancer resistance protein and P-glycoprotein limit sorafenib brain accumulation PMID: 20103600
    50. A single application of mdr1b/1a siRNA followed by treatment with conventionally used cytostatics resulted in more than threefold decrease in lymphosarcoma tumor size as compared with the control animals. PMID: 20470373

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Apical cell membrane.
  • 蛋白家族：
    ABC transporter superfamily, ABCB family, Multidrug resistance exporter (TC 3.A.1.201) subfamily
  • 数据库链接：

    KEGG: mmu:18669

    STRING: 10090.ENSMUSP00000009058

    UniGene: Mm.146649

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