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  4. Recombinant Mouse Multidrug resistance-associated protein 6 (Abcc6), partial

Recombinant Mouse Multidrug resistance-associated protein 6 (Abcc6), partial

  • 中文名称：
    Recombinant Mouse Multidrug resistance-associated protein 6(Abcc6) ,partial
  • 货号：
    CSB-YP879510MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Multidrug resistance-associated protein 6(Abcc6) ,partial
  • 货号：
    CSB-EP879510MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Multidrug resistance-associated protein 6(Abcc6) ,partial
  • 货号：
    CSB-EP879510MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Multidrug resistance-associated protein 6(Abcc6) ,partial
  • 货号：
    CSB-BP879510MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Multidrug resistance-associated protein 6(Abcc6) ,partial
  • 货号：
    CSB-MP879510MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Abcc6
  • Uniprot No.：
    Q9R1S7
  • 别名：
    Abcc6; Mrp6; Multidrug resistance-associated protein 6; ATP-binding cassette sub-family C member 6
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Mediates ATP-dependent transport of glutathione conjugates such as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS) (in vitro), and an anionic cyclopentapeptide endothelin antagonist, BQ-123.; Mediates the release of nucleoside triphosphates, predominantly ATP, into the circulation, where it is rapidly converted into AMP and the mineralization inhibitor inorganic pyrophosphate (PPi) by the ecto-enzyme ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1), therefore playing a role in PPi homeostasis.
  • 基因功能参考文献：
    1. abrogated ABCC6 function does cause alterations in the metabolic profile of the liver in accordance with PXE being a metabolic disease originating from liver disturbance PMID: 27758107
    2. bisphosphonates may be helpful for prevention of mineral deposits in Pseudoxanthoma elasticum and generalized arterial calcification of infancy caused by mutations in the ABCC6 gene. PMID: 25607347
    3. In a mouse model of CKD, ABCC6 protein expression was decreased in liver and kidney, however mRNA levels were unchanged. PMID: 24994603
    4. In the Abcc6(-/-) genotype, dermal fibroblasts actively contribute to changes that promote matrix calcification; these cells can be further modulated with time by the calcified environment, contributing to the age-dependent progression. PMID: 24670382
    5. This study showed that the expression of ABCC6 in liver is an important determinant of calcification in cardiac tissues in response to injuries PMID: 24479134
    6. Magnesium oxide reduces carotid intima media thickness in Abcc6-/- mouse model for pseudoxanthoma elasticum. PMID: 24330694
    7. Studied the role of genetic modulation and the role of diet in nephrocalcinosis using two established mouse models of ectopic mineralization, Abcc6(tm1Jfk) and Enpp1(asj) mice. PMID: 24732453
    8. Report lower elasticity and increased myogenic tone without major changes in agonist-dependent contraction in aged Abcc6(-/-) mouse model of pseudoxanthoma elasticum. PMID: 24675664
    9. the development of cardiac hypertrophy in the 24-month-old Abcc6(-/-) mice suggests that old pseudoxanthoma elasticum patients might be prone to developing late cardiopathy. PMID: 23935882
    10. ABCC6 is in the basolateral membrane, mediating the sinusoidal efflux of a metabolite from the hepatocytes to systemic circulation. PMID: 23625951
    11. A single-nucleotide polymorphism in the Abcc6 gene associates with connective tissue mineralization in mice similar to targeted models for pseudoxanthoma elasticum. PMID: 23014343
    12. Our finding that ABCC6 localizes to the mitochondria-associated membrane has implications for its mechanism of action in normal and diseased states. PMID: 22811557
    13. Abcc6 as a novel modulator of cardiac myocyte survival after cardiac ischemia-reperfusion (I/R) injury. PMID: 21979437
    14. These results show that VK3GS is not the essential metabolite transported by ABCC6 from the liver and preventing the symptoms of pseudoxanthoma elasticum. PMID: 22056557
    15. genetic and biochemical characterization; contribution to aortic calcification PMID: 12115029
    16. Upregulation of Abca4 in the liver is a tissue-specific compensatory consequence of the 'knock-out' of Abcc6 in mice. PMID: 21435020
    17. The level of Abcc6 synthesis was investigated in the liver and kidneys and the phenotype of a beta-thalassemia mouse model (Hbbth3/+) for a period of 14 months. PMID: 21281810
    18. Abcc6 and Rag1 have roles in ectopic mineralization in a murine model of pseudoxanthoma elasticum PMID: 20185580
    19. the presence of Abcc6 in elastic tissues is not required for elastic fiber assembly PMID: 15900406
    20. Targeted ablation of the mouse Abcc6 gene resulted in profound mineralization of skin, arterial blood vessels, and retina. PMID: 16135817
    21. High level of expression of ABCC6 in the liver and the kidney, whereas very low level of expression in a variety of other tissues was noted. PMID: 16297187
    22. The involvement of both HNF4alpha and NF-E2 in Abcc6 gene regulation suggests that Abcc6 might be involved in a detoxification processes related to hemoglobin or heme. PMID: 16997394
    23. Abcc6-/- serum had less ability to prevent the mineral deposition induced by inorganic phosphate PMID: 17273159
    24. Abcc6 is the major causal gene for dystrophic cardiac calcification in mice through integrative genomics PMID: 17360558
    25. The results emphasize the importance of the Abcc6 gene in the ectopic mineralization process and suggest that other members of the Abcc family, particularly Abcc1 and Abcc3, do not modulate the effects of Abcc6 in this model of pseudoxanthoma elasticum. PMID: 17845218
    26. Abcc6(-/-) mice suffer from chronic oxidative stress but this does not contribute to connective tissue mineralization, the hallmark of pseudoxanthoma elasticum PMID: 18049453
    27. splice variant affects the biological function of MRP6 protein and is a cause of DCC in mice. PMID: 18201967
    28. pseudoxanthoma elasticum is a systemic metabolic disorder with secondary mineralization of connective tissues in Abcc6 knockout mice PMID: 18685618
    29. targeted ablation of the Abcc6 gene in both alles results in a model of pseudoxanthoma elasticum PMID: 19122649

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  • 亚细胞定位：
    Basolateral cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    ABC transporter superfamily, ABCC family, Conjugate transporter (TC 3.A.1.208) subfamily
  • 数据库链接：

    KEGG: mmu:27421

    STRING: 10090.ENSMUSP00000002850

    UniGene: Mm.63514

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