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  4. Recombinant Mouse Multidrug resistance-associated protein 1 (Abcc1), partial

Recombinant Mouse Multidrug resistance-associated protein 1 (Abcc1), partial

  • 中文名称：
    Recombinant Mouse Multidrug resistance-associated protein 1(Abcc1) ,partial
  • 货号：
    CSB-YP001056MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Multidrug resistance-associated protein 1(Abcc1) ,partial
  • 货号：
    CSB-EP001056MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Multidrug resistance-associated protein 1(Abcc1) ,partial
  • 货号：
    CSB-EP001056MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Multidrug resistance-associated protein 1(Abcc1) ,partial
  • 货号：
    CSB-BP001056MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Multidrug resistance-associated protein 1(Abcc1) ,partial
  • 货号：
    CSB-MP001056MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Abcc1
  • Uniprot No.：
    O35379
  • 别名：
    Abcc1; Abcc1a; Abcc1b; Mdrap; Mrp; Multidrug resistance-associated protein 1; EC 7.6.2.2; ATP-binding cassette sub-family C member 1; Glutathione-S-conjugate-translocating ATPase ABCC1; EC 7.6.2.3; Leukotriene C(4) transporter; LTC4 transporter
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export. Hydrolyzes ATP with low efficiency. Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation. Participates in inflammatory response by allowing export of leukotriene C4 from leukotriene C4-synthezing cells.
  • 基因功能参考文献：
    1. The authors conclude that MRP1 assists in depression of polymorphonuclear cell (PMN) migration by effluxing a molecule that inhibits the proinflammatory effects of MRP2 activity. PMID: 29976647
    2. Mrp1 protects cardiac myocytes and fibroblasts against doxorubicin-induced toxicity, potentially by regulating extracellular redox states. PMID: 26822305
    3. Loss of ABCC1 expression is associated with neonatal hyperbilirubinemia. PMID: 28025333
    4. Data, including data from studies in knockout mice, suggest that Mrp1 is involved in development of vascular endothelial dysfunction in diabetic angiopathy; Mrp1 appears to be required for oxidative stress in endothelial cells due to hyperglycemia. PMID: 26908299
    5. Oxidant-enriched Tumorigenic Endothelial Cells (EOMA) cells survive a heavy oxidant burden by rapid efflux of GSSG, which is lethal if trapped within the cell. A hyperactive MRP-1 system for GSSG efflux acts as a critical survival factor for these cells, making it a potential target for EOMA therapeutics. PMID: 26961872
    6. P-gp, Bcrp, Mrp1 and Mrp4 are differentially expressed at the outer and inner blood retinal barrier, resulting in an altered ability to limit substrate distribution at the retina as compared with the blood brain barrier PMID: 26507673
    7. Lentivirus-based RNAi stably knocks down the expression of the Mrp1 gene in the established TM4 sertoli cell line. PMID: 25403683
    8. neprilysin x ABCC1 double-deficient mice present a new model for early effects of amyloid-beta-related mild cognitive impairment that allows investigations without artificial overexpression of inherited Alzheimer's disease genes PMID: 25991605
    9. Expression of apoA-I or ABCA1 can reduce steatosis by decreasing lipid storage in hepatocytes through lipid transport and may also reduce endoplasmic reticulum stress, further lessening hepatic steatosis PMID: 24219083
    10. Loss of Mrp1 coupled with reductions in steroid hormone levels leads to alterations in extrahepatic phase I, phase II and phase III metabolizing enzymes in a tissue-specific manner. PMID: 22522787
    11. Cd or H(2)O(2) exposure increased the expression of key transport genes, Mrp1 and Mrp2, in WT cells but not in metallothionein-null cells. PMID: 22914987
    12. These results identify Mrp1 as the transporter essential for S1P efflux from the endothelial cells and thus for inside-out S1P signaling to P-glycoprotein at the blood-brain and blood-spinal cord barriers. PMID: 23168528
    13. investigated changes in the expression and activity of multidrug resistance protein 1 and multidrug resistance-associated protein 1 in highly purified lung dendritic cells during aging PMID: 22451472
    14. Data suggest glutathione offers neuroprotection against methylmercury toxicity in a manner dependent on MRP1-mediated efflux. PMID: 22464990
    15. Results show that the presence of Mdr1a, Mdr1b (P-glycoprotein Pgp) and multidrug resistance-associated protein (MRP1) encoding genes in the olfactory mucosa of rat and mouse was confirmed by RT-PCR. PMID: 22563480
    16. Assessment of activity, exploratory behavior, and anxiety levels revealed behavioral alterations in Abcb1(0/0) and Abcc1 (0/0) mice, whereas Abcg2(0/0) mice were mostly unaffected. PMID: 22545122
    17. Apolipoprotein-E controls adenosine triphosphate-binding cassette transporters ABCB1 and ABCC1 on cerebral microvessels after methamphetamine intoxication.( PMID: 22426312
    18. MRP1 and alpha crystallin are potential therapeutic targets in pathological retinal degenerative disorders linked to oxidative stress. PMID: 22442691
    19. DNIC storage function of GST P1-1 and ability of MRP1 to efflux DNICs are vital in protection against NO cytotoxicity PMID: 22084240
    20. the transporter ABCC1 has an important role in cerebral amyloid-beta clearance and accumulation PMID: 21881209
    21. MDR1 and MRP1 in LDCs may be involved in protective functions through their efflux activities. PMID: 21763326
    22. This study showed that nearly complete oxidation of free cholesterol in the plasma membrane of MRP1-expressing baby hamster kidney cells did not affect MRP1 localization in lipid rafts or its efflux function. PMID: 21609321
    23. Treatment of macrophages with LPS resulted in 2-fold increases of MRP-1 expression or functional activity PMID: 19894120
    24. cortical actin disruption results in reduced Mrp1/MRP1 (Abcc1/ABCC1) activity concomitant with a partial shift of Mrp1/MRP1 (Abcc1/ABCC1) out of lipid raft fractions and partial internalization of the ABC transporter PMID: 21045108
    25. Results indicate that Mrp1-/- mice have lowered steroid hormones levels, and suggests that upregulation of steroid biosynthetic enzymes may be an attempt to maintain proper steroid hormone homeostasis. PMID: 20178799
    26. Identification of multidrug resistance protein 1 (MRP1/ABCC1) as a molecular gate for cellular export of cobalamin. PMID: 19897579
    27. LTC(4) stimulation results in a significant activation of MRP1, but does not alter MRP1 expression PMID: 19685171
    28. polyclonal antibodies recognizing both human and rodent MRP1 PMID: 11689020
    29. Mice lacking mrp1 have significantly increased hepatic transcription of at least two other ATP-binding cassette transporters PMID: 14742140
    30. Mrp1 was rather expressed than P-gp in parenchyma astrocytes and in glia limitans lining the meninges. PMID: 15328029
    31. Mrp1 limits intracellular accumulation of unconjugated bilirubin and thus decreases its cytotoxicity. PMID: 16458308
    32. IFN-gamma can protect against NaAs-induced acute renal injury, probably by maintaining Nrf2-mediated intrarenal MRP1 gene expression. PMID: 17003472
    33. The effects of lipopolysaccharides on ABCC1 transporters in RAW macrophages and inhibitors of these transporters were capable of inhibiting nitrite production suggesting a role for ABCC1 transporters in the inflammatory process. PMID: 17169333
    34. Mrp1 triple knock-out mice lacking the genes for Mrp1 and Mdr1a/1b are more susceptible to developing features of chronic obstructive pulmonary disease (COPD) than their wild-type littermates. PMID: 17617921
    35. Abcc6/1(-/-) double knock-out mice exhibited connective tissue mineralization similar to that in Abcc6 (-/-) mice. PMID: 17845218
    36. MRP1 plays an important role in the development of allergic airway inflammation through regulation of IgE-mediated cysteinyl-leukotriene export from mast cells PMID: 18931056

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    ABC transporter superfamily, ABCC family, Conjugate transporter (TC 3.A.1.208) subfamily
  • 数据库链接：

    KEGG: mmu:17250

    STRING: 10090.ENSMUSP00000097743

    UniGene: Mm.196634

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