Your Good Partner in Biology Research

中文简体

CSF2｜ CTLA4｜ DLL3｜ EGFR｜ IL4｜ IL4R｜ LAG3｜ MSTN｜ NECTIN4｜ NT5E｜ SEZ6｜ TM4SF1｜ TNFSF13｜ TPO

  1. 首页
  2. 蛋白
  3. 重组蛋白
  4. Recombinant Mouse Mimecan (Ogn)

Recombinant Mouse Mimecan (Ogn)

In Stock
  • 中文名称：
    Recombinant Mouse Mimecan (Ogn)
  • 货号：
    CSB-EP733811MO
  • 规格：
    ￥1836
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 85% as determined by SDS-PAGE.
  • 生物活性：
    Not Test
  • 基因名：
    Ogn
  • Uniprot No.：
    Q62000
  • 别名：
    Osteoglycin
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 来源：
    E.coli
  • 分子量：
    38.7 kDa
  • 表达区域：
    20-298aa
  • 氨基酸序列
    APQSQLDSHVNYEYATGNSEETKFSQDYEDKYLDGKSIKEKETMIIPDEKSLQLQKDEVIPSLPTKKENDEMPTCLLCVCLSGSVYCEEVDIDAVPPLPKESAYLYARFNKIKKLTAKDFADMPNLRRLDFTGNLIEDIEDGTFSKLSLLEELTLAENQLLRLPVLPPKLTLLNAKHNKIKSKGIKANTFKKLNKLSFLYLDHNDLESVPPNLPESLRVIHLQFNSISSLTDDTFCKANDTRYIRERIEEIRLEGNPIALGKHPNSFICLKRLPIGSYF
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    C-terminal 6xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    3-7 business days
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

相关产品

Ogn Proteins

靶点详情

  • 功能：
    Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2.
  • 基因功能参考文献：
    1. NK cells promote fetal development through the secretion of growth-promoting factors, pleiotrophin and osteoglycin. PMID: 29262349
    2. These results reveal a novel pathway in which miR-155 inhibits Ogn expression to regulate proliferation and differentiation of C2C12 myoblast cells. PMID: 29161332
    3. elevated LIP/LAP ratio robustly increased Ogn expression and cell death under stress by modulating the mitogen-activated protein kinase/activator protein 1 pathway (MAPK/AP-1). PMID: 28383550
    4. OGN plays a critical role in negatively regulating ischaemia-induced angiogenesis by inhibiting VEGF-VEGFR2 signalling and thereby attenuating endothelial cells tube formation, proliferation, and migration. PMID: 28069703
    5. The current study discovered a novel 72-kDa chondroitin sulfate-OGN that is specific for innate immune cells. This variant is able to bind and activate TLR4. PMID: 27878326
    6. mimecan is a satiety hormone in adipose tissue, and that mimecan inhibits food intake independently of leptin signaling by inducing IL-1beta and IL-6 expression in the hypothalamus. PMID: 26870797
    7. lack of the proteoglycan OGN does not affect the progression of atherosclerosis in mice PMID: 25463067
    8. The expression of osteoglycin decreased in the medial, basolateral, and central amygdala regions after chronic immobilization stress in mice. PMID: 22672618
    9. Osteoglycin may be a crucial humoral bone anabolic factor that is produced by muscle tissues. PMID: 22351757
    10. The temporal-spatial specific pattern and unique co-localization of Dspp, Mepe, Mimecan and Versican suggest they play complementary roles during odontogenesis. PMID: 22042093
    11. even though there are 3-5 glucocorticoid response elements in the mimecan promoter, glucocorticoid may regulate mimecan transcription indirectly through the synthesis of intermediate proteins PMID: 21938403
    12. Mimecan in pituitary corticotroph cells may regulate adrenocorticotrophic hormone secretion and the hypothalamo-pituitary-adrenal axis PMID: 21664248
    13. High expression of osteoglycin decreases the gelatinase activity of hepatocarcinoma Hca-F cells cultured with extract of lymph node. PMID: 20027687
    14. processing of the prodomain of OGN by BMP-1 potentiates the ability of OGN to modulate the formation of collagen fibrils PMID: 15292192
    15. Ogn-deficient mice, when analyzed by auditory brainstem response and distortion product otoacoustic emissions, have normal hearing thresholds PMID: 18243607
    16. In summary, high expression of osteoglycin decreases the metastatic capability of Hca-F to lymph nodes. PMID: 18401533

    显示更多

    收起更多

  • 亚细胞定位：
    Secreted, extracellular space, extracellular matrix.
  • 蛋白家族：
    Small leucine-rich proteoglycan (SLRP) family, SLRP class III subfamily
  • 数据库链接：

    KEGG: mmu:18295

    STRING: 10090.ENSMUSP00000021822

    UniGene: Mm.4258

Most popular with customers

产品中心
特别关注


X
九游平台-九游(中国) | 米兰体育-米兰体育（中国） | 开云手机在线登陆入口 | 江南官方体育网页版 | 开云网页版 | 开云官方在线入口 | 开云电子体育 | 开云官方链接 | 江南网页版页面登录 |