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  4. Recombinant Mouse Microtubule-associated protein 6 (Map6), partial

Recombinant Mouse Microtubule-associated protein 6 (Map6), partial

  • 中文名称：
    小鼠Map6重组蛋白
  • 货号：
    CSB-YP013441MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Map6重组蛋白
  • 货号：
    CSB-EP013441MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Map6重组蛋白
  • 货号：
    CSB-EP013441MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Map6重组蛋白
  • 货号：
    CSB-BP013441MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Map6重组蛋白
  • 货号：
    CSB-MP013441MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Map6
  • Uniprot No.：
    Q7TSJ2
  • 别名：
    Map6; Mtap6Microtubule-associated protein 6; MAP-6; Stable tubule-only polypeptide; STOP
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Involved in microtubule stabilization in many cell types, including neuronal cells. Specifically has microtubule cold stabilizing activity. Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with TMEM106B. Regulates KIF5A-mediated axonal cargo transport. Regulates axonal growth during neuron polarization.
  • 基因功能参考文献：
    1. MAP6 is involved in the formation and the maintenance of mature post-synaptic dendritic spines.MAP6 is involved in the stabilisation of actin filaments in dendritic spines. PMID: 30224655
    2. MAP6 deletion results in alterations of microtubule network, sarcoplasmic reticulum organization and calcium release. PMID: 30231928
    3. show that MAP6 proteins interact directly with both Tctex1 and the C-terminus of Cav2.2/N-type calcium channels. PMID: 29094416
    4. MAP6 is present at the Golgi complex and in secretory vesicles in unpolarized cells and re-distributed to newly forming axons, where it binds and stabilizes axonal microtubules. A palmitoylation cycle controls MAP6 membrane-microtubule shuttling and is required for its polarized distribution in axons. PMID: 28521134
    5. Mice deficient in stable tubule only polypeptide (STOP) show sleep/wake patterns that resemble those seen in patients with schizophrenia. PMID: 26940700
    6. MAP6 deletion disrupts brain connectivity and is associated with a lack of post-commissural fornix fibres. MAP6 contributes to fornix development by regulating axonal elongation induced by Semaphorin 3E. PMID: 26037503
    7. STOP/Map6 knockout mice are a valid model for cognitive deficits in schizophrenia. PMID: 23002183
    8. MAP6 might serve as a temperature sensor adapting its conformation according to the temperature to maintain the cellular microtubule network in organisms exposed to temperature decrease. PMID: 22904321
    9. Deletion of STOP protein in mice causes deep alterations in mood and cognitive performance and indicates that STOP protein might have a crucial role in the development of serotonin and norepinephrine networks. PMID: 22146001
    10. STOP null mice displayed elevated levels of endogenous morphine, as well as an increase of morphine receptor affinity and density in brain. This was correlated with hypernociception and impaired pharmacological sensitivity to mu opioid receptor ligands PMID: 21172011
    11. Loss of STOP protein impairs peripheral olfactory neurogenesis. PMID: 20856814
    12. Deletion of the STOP protein elicits an imbalance in serotonin neurotransmission and reduces anxiety in STOP knock-out mice. PMID: 20969568
    13. the study suggest D. alpha enhances the novel objective recognition task performance of STOP null mice by increasing production of nitric oxide. PMID: 20336057
    14. STOP protein localization and content in muscle cells was also muscle type-specific. PMID: 19888554
    15. STOP-/- mice had no detectable defects in brain anatomy but showed synaptic defects, with depleted synaptic vesicle pools and impaired synaptic plasticity, associated with severe behavioral disorders. PMID: 12231625
    16. interacts with neuronal tubulin independently of polyglutamylation PMID: 12359221
    17. there is a single neuronal specific promoter for transcription of E- and N-STOP mRNAs. F-STOP mRNA transcription is regulated by a distinct promoter that lies within coding sequences expressed in neuronal E- and N-STOP isoforms. PMID: 12782132
    18. Stop knockout mice disply a schizophrenia=like phenotype in both locomotor activity and PPI model. PMID: 16046005
    19. STOP phosphorylation by CaMKII may promote STOP translocation from microtubules to synaptic compartments where it may interact with actin, which could be important for STOP function in synaptic plasticity PMID: 16651267
    20. These results demonstrate that both STOP and MBP function as microtubule-stabilizing proteins in differentiating oligodendrocytes and could be important for the morphogenetic function of MBP. PMID: 16773649
    21. Provide evidence for a role for microtubules in synaptic function, and suggest that STOP, or other microtubule proteins, may contribute to the synaptic pathology of schizophrenia. PMID: 17050659
    22. The strong expression of STOP lacZ reporter gene observed in brain is confined to areas that may be involved in the schizophrenia-related symptoms observed in STOP-deficient mice. PMID: 17394261
    23. The deletion of the ubiquitous STOP protein elicited restricted alterations in ACh components. PMID: 17512560
    24. STOP null mice exhibited both a progression of locomotor activity defects over time and subtle alterations in the prepubertal period. PMID: 17559095
    25. STOP null mice displayed exaggerated neuroanatomical deficits reminiscent of those observed among individuals with schizophrenia PMID: 17907815
    26. hyperdopaminergic activity, olfactory deficits, and sleep disturbances in STOP-KO mice that have also been reported in schizophrenic patients PMID: 17969102
    27. Microtubule-associated STOP protein deletion triggers restricted changes in dopaminergic neurotransmission. PMID: 18199119
    28. STOP null mice may provide a useful model to understand the neurobiological correlates of social and cognitive defects in schizophrenia PMID: 18804150

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton. Golgi apparatus. Cell projection, axon. Cell projection, dendrite. Cytoplasmic vesicle, secretory vesicle membrane; Lipid-anchor; Cytoplasmic side.
  • 蛋白家族：
    STOP family
  • 组织特异性：
    Isoform 1 is specifically expressed in adult brain. Isoform 2 is predominantly expressed in embryonic brain; expression persists at low levels in the adult brain. Isoform 3 is expressed at high levels in lung and at lower levels in testis, heart, muscle a
  • 数据库链接：

    KEGG: mmu:17760

    STRING: 10090.ENSMUSP00000064787

    UniGene: Mm.154087

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