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  4. Recombinant Mouse Microtubule-associated protein 1S (Map1s), partial

Recombinant Mouse Microtubule-associated protein 1S (Map1s), partial

  • 中文名称：
    小鼠Map1s重组蛋白
  • 货号：
    CSB-YP013407MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Map1s重组蛋白
  • 货号：
    CSB-EP013407MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Map1s重组蛋白
  • 货号：
    CSB-BP013407MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Map1s重组蛋白
  • 货号：
    CSB-MP013407MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Map1s
  • Uniprot No.：
    Q8C052
  • 别名：
    Map1s; Bpy2ip1; Map8; Mtap1sMicrotubule-associated protein 1S; MAP-1S; BPY2-interacting protein 1; Microtubule-associated protein 8) [Cleaved into: MAP1S heavy chain; MAP1S light chain]
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

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Map1s Proteins

靶点详情

  • 功能：
    Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles.
  • 基因功能参考文献：
    1. Depletion of MAP1S in mice leads to an accumulation of fibrosis-related proteins and the development of renal fibrosis in aged mice. PMID: 27236336
    2. MAP1S-mediated autophagy plays an important role in maintaining mouse lifespan especially in the presence of extra amount of fibronectin. PMID: 26750654
    3. Data (including data from studies in knockout mice) suggest that Map1s interacts directly with MyD88 (myeloid differentiation primary response gene 88), a key adaptor of Toll-like receptors, as phagocytosis of bacteria is initiated in macrophages. PMID: 26565030
    4. Data establish a link between MAP1S-enhanced autophagy and suppression of genomic instability and tumorigenesis. PMID: 22037873
    5. clarify roles of MAP1S in bridging microtubules and mitochondria with autophagic and mitophagic initiation, maturation, trafficking, and lysosomal clearance. PMID: 21262964
    6. MAP8 is a novel microtubule associated protein containing two microtubule binding domains. PMID: 16297881
    7. Axonal transport impairment may be a deleterious consequence of accumulated, toxic MAP8 protein. PMID: 16565160

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  • 亚细胞定位：
    Nucleus. Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle.
  • 蛋白家族：
    MAP1 family
  • 组织特异性：
    Expressed in ventral and dorsal horns of the spinal cord, hippocampus, cerebral cortex, molecular, Purkinje and granular cell layers of the cerebellum and in dorsal root ganglia of the PNS (at protein level). Expressed in brain, testis, heart, lung, kidne
  • 数据库链接：

    KEGG: mmu:270058

    STRING: 10090.ENSMUSP00000019405

    UniGene: Mm.248559

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