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  4. Recombinant Mouse Metabotropic glutamate receptor 8 (Grm8), partial

Recombinant Mouse Metabotropic glutamate receptor 8 (Grm8), partial

  • 中文名称：
    小鼠Grm8重组蛋白
  • 货号：
    CSB-YP009938MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Grm8重组蛋白
  • 货号：
    CSB-EP009938MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Grm8重组蛋白
  • 货号：
    CSB-EP009938MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Grm8重组蛋白
  • 货号：
    CSB-BP009938MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Grm8重组蛋白
  • 货号：
    CSB-MP009938MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Grm8
  • Uniprot No.：
    P47743
  • 别名：
    Grm8; Gprc1h; Mglur8Metabotropic glutamate receptor 8; mGluR8
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.
  • 基因功能参考文献：
    1. the data of this study revealed very different roles for mGlu8 in amygdala synaptic transmission, fear learning and its expression PMID: 23664812
    2. In the dentate gyrus of mGluR8 receptor-deficient mice, effects from selective agonists are linked to the lateral and medial perforant pathway. PMID: 23220400
    3. mGluR8 is an important regulator of excitatory transmission in the bed nucleus of the stria terminalis, and is selectively disrupted by both acute and chronic stress. PMID: 21451497
    4. mGluR8 deficiency decreased measures of anxiety in the elevated plus maze and the acoustic startle response in female mice. PMID: 20080129
    5. Might be potential target for disorders with pathophysiological changes in brain areas where mGlu8 modulates glutamate and GABA transmission, especially in anxiety disorders involving exaggerated contextual fear. PMID: 19740090
    6. The role of mGluR8 as a presynaptic autoreceptor and its contribution to cognitive processes are hypothesized and the utility of gene targeting is discussed as compared to pharmacological methods. PMID: 12213278
    7. Naive mGlu8 receptor-deficient mice show increased anxiety-related behavior in the elevated plus maze in low illumination conditions (red light) compared to wild-type mice. PMID: 12213279
    8. The increased anxiety-related behavior of mGlu8 receptor knockout mice in the elevated plus maze is associated with an increased number of c-Fos positive cells in the centromedial nucleus of the thalamus compared with wild-type mice. PMID: 12946709
    9. Increased measures of anxiety and weight gain in mice lacking the group III metabotropic glutamate receptor mGluR8. PMID: 16045496
    10. mGluR8 was localized in two broad bands, one each in the OFF and ON layers of the IPL; mGluR8 immunoreactivity was evident in the OFF plexus of cholinergic amacrine cell processes PMID: 17311335

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 3 family
  • 组织特异性：
    Strongly expressed in olfactory bulb, accessory olfactory bulb, and mammillary body. Weaker expression in the retina, and in scattered cells in the cortex and hindbrain.
  • 数据库链接：

    KEGG: mmu:14823

    STRING: 10090.ENSMUSP00000110978

    UniGene: Mm.320732

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