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  4. Recombinant Mouse Metabotropic glutamate receptor 7 (Grm7), partial

Recombinant Mouse Metabotropic glutamate receptor 7 (Grm7), partial

  • 中文名称：
    小鼠Grm7重组蛋白
  • 货号：
    CSB-YP715014MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Grm7重组蛋白
  • 货号：
    CSB-EP715014MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Grm7重组蛋白
  • 货号：
    CSB-EP715014MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Grm7重组蛋白
  • 货号：
    CSB-BP715014MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Grm7重组蛋白
  • 货号：
    CSB-MP715014MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Grm7
  • Uniprot No.：
    Q68ED2
  • 别名：
    Grm7; Gprc1g; Mglur7Metabotropic glutamate receptor 7; mGluR7
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    G-protein coupled receptor activated by glutamate that regulates axon outgrowth through the MAPK-cAMP-PKA signaling pathway during neuronal development. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase that it inhibits.
  • 基因功能参考文献：
    1. mGlu7 may be a potential therapeutic target for multiple aspects of the Rett phenotype. PMID: 28814546
    2. The mGlu7 receptor was found to be involved in a wide range of behavioral and physiological alterations in response to chronic psychosocial stress exposure. PMID: 27188844
    3. This study provides evidence for mGlu7 receptor-mediated tonic modulation of a physiological function in vivo preventing synchronous and potentially pathological oscillations. PMID: 27199672
    4. Analysis of mGluR7 KO mice, c-Fos expression, and cerebral MMPIP microinjection indicate that inhibition of mGluR7 impairs intermale aggression owing to information processing dysfunction within the bed nucleus of the stria terminalis PMID: 26149357
    5. muscle does not appear to require high levels of SMN above what is produced by two copies of SMN2 PMID: 26276812
    6. SAM68 is a physiological regulator of SMN2 splicing in a spinal muscular atrophy mouse model. PMID: 26438828
    7. Hyperoxia treatment increased the inclusion of SMN2 exon 7 in skeletal muscles and resulted in improved motor function. PMID: 22763238
    8. Elfn1 recruits mGluR7 to synaptic sites.A trans interaction of Elfn1 and mGluR7 controls targeted interneuron synapse development. PMID: 25047565
    9. GRM7 regulates the phosphorylation of CREB protein and the expression of Yes-associated protein (YAP) by directly interacting with CaM, which subsequently regulates the expression of CyclinD1 and ultimately affects early cortical development. PMID: 25921811
    10. Modeling the selective interaction between XAP044 and mGlu7's Venus flytrap domain, whose three-dimensional structure is already known, will facilitate future drug development supported by computer-assisted drug design PMID: 24596089
    11. The data of this study revealed very different roles for mGlu7 in amygdala synaptic transmission, fear learning and its expression PMID: 23664812
    12. These data suggest targeting mGlu7 receptors with selective antagonist drugs may be an effective and safe strategy for the treatment of anxiety disorders. PMID: 23603202
    13. Glutamate release mediated by GluR7 at nerve terminals is influenced by divalent calcium channel type Ca2+ ionophore. PMID: 23174341
    14. mGluR7, by affecting the cofilin/actin signaling, regulates NMDAR trafficking and function PMID: 22287544
    15. The genomic integration site of the mGluR7 transgene is in intron 4 in spinal muscular atrophy transgenic mice, especially those that have extended survival. PMID: 21396450
    16. Phorbol esters and prolonged activation of mGlu7 receptors both potentiate glutamate release via a common intracellular signalling pathway that occurs in nerve terminals containing N-type divalent calcium channels. PMID: 21143597
    17. This study suggested that mGlu7 receptor is involved in the regulation of GABAergic system activity at the level of GABA synthesised enzymes, specific proteins expressed by GABAergic neurons and metabotropic receptor for GABA. PMID: 20353761
    18. mGlu7 receptors may not only regulate the central components of chronic stress, but may also have a role in the regulation of fluid & electrolyte transport which is significantly disrupted in diseases such as IBS, by enhancing colonic secretory activity PMID: 20423346
    19. The mGluR7 may play a pivotal role in mechanisms that regulate behavioural responses to aversive states. Therefore, drugs acting at mGluR7 may provide novel treatments for psychiatric disorders such as depression and anxiety. PMID: 12814372
    20. genetic ablation of mGluR7 in mice interferes at multiple sites in the neuronal circuitry and molecular pathways implicated in affective disorders. PMID: 16237391
    21. mGluR4 and mGluR7 were located close to bipolar cell ribbons PMID: 17311335
    22. Metabotropic glutamate receptor 7 (GluR7) is uniquely expressed in dendrites of the ON cone bipolar cell pathway and reveals a unique connection to rod cells. PMID: 17553999
    23. gene mapping and gene mRNA expression data in segregating and congenic mice identify glutamate receptor metabotropic 7 (Grm7) as a cis-regulated gene and suggest a role in alcohol consumption PMID: 17936574
    24. The observed delays in the acquisition of complicated stimulus associations across conditioning procedures may suggest a critical role for mGluR7 in neurocognitive functions and psychopathology PMID: 18289889
    25. group III mGluRs regulate spontaneous glutamate release of terminals projecting to dopamine cells in the ventral tegmental area of mice and this effect is most likely mediated by mGluR7 PMID: 18534761
    26. PICK1 binding to the C-terminal region of mGluR7a is crucial for agonist-triggered presynaptic signaling in vivo. PMID: 18716219
    27. GRM7 is expressed in the hair cells and in spiral ganglion cells of the inner ear of human and mouse. PMID: 19047183

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 3 family
  • 数据库链接：

    KEGG: mmu:108073

    STRING: 10090.ENSMUSP00000133957

    UniGene: Mm.240881

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