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  4. Recombinant Mouse Metabotropic glutamate receptor 4 (Grm4), partial

Recombinant Mouse Metabotropic glutamate receptor 4 (Grm4), partial

  • 中文名称：
    小鼠Grm4重组蛋白
  • 货号：
    CSB-YP731564MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Grm4重组蛋白
  • 货号：
    CSB-EP731564MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Grm4重组蛋白
  • 货号：
    CSB-EP731564MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Grm4重组蛋白
  • 货号：
    CSB-BP731564MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Grm4重组蛋白
  • 货号：
    CSB-MP731564MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Grm4
  • Uniprot No.：
    Q68EF4
  • 别名：
    Grm4; Gprc1d; Mglur4Metabotropic glutamate receptor 4; mGluR4
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.
  • 基因功能参考文献：
    1. This immuno-electron microscopic studies suggest that pre-synaptic metabotropic glutamate receptor 4 (mGluR4) in striatal glutamatergic terminals is expressed almost exclusively in cortical boutons to subserve regulatory influences upon a large contingent of corticostriatal terminals that preferentially target putative "indirect" pathway striatal projection neurons in mice. PMID: 26832920
    2. Study assessed the actions of the first mGlur4-selective orthosteric agonist, LSP4-2022, in several tests reflecting positive, negative, and cognitive symptoms of schizophrenia; results suggest that the interplay between mGlu4 and GABAB receptors may become the basis for a novel therapy for schizophrenic patients with predomination of positive symptoms PMID: 26769224
    3. A functional hetero-complex is formed with mGluR2 and mGluR4 in central nervous system. PMID: 24381270
    4. mGluR4-/- mice show increased long-term potentiation in hippocampal CA1 region and improved maze learning. PMID: 23714430
    5. data support a role for mGluR4 signaling in acquisition of fear learning and memory. PMID: 22884897
    6. The expression of mGluR4 is down-regulated in the cardiomyocyte differentiation of embryonic stem cells. PMID: 22927070
    7. These data indicate that effects of mGluR4 on sensorimotor function and measures of anxiety, but not cued fear conditioning, are critically modulated by sex and age. PMID: 22227508
    8. A role for mGlu4 was found whereby simultaneous activation with GABA(A) receptors acts to amplify glutamate release at parallel fiber-Purkinje cell synapses. PMID: 22145864
    9. These data indicate that activation of mGlu4 receptors limit the development of brain damage after permanent or transient focal ischemia PMID: 21157475
    10. Grm4 modulates adaptive immunity and restrains neuroinflammation. PMID: 20657581
    11. The most intense mGluR4 labelling was in the cerebellar cortex, basal ganglia, the sensory relay nuclei of the thalamus, and some hippocampal areas. Immunolabelling was most intense in presynaptic active zones. PMID: 11906782
    12. These data suggest that mGlu4 receptor enhancers are promising drugs for the treatment of medulloblastomas. PMID: 16899734
    13. Our results suggest a role for mGluR1 in promoting seizure susceptibility as well as for mGluR4 to counteract excitatory activity and seizure-associated vulnerability of hippocampal neurons. PMID: 17446080

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 3 family
  • 数据库链接：

    KEGG: mmu:268934

    STRING: 10090.ENSMUSP00000130092

    UniGene: Mm.358940

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