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  4. Recombinant Mouse Mediator of RNA polymerase II transcription subunit 23 (Med23), partial

Recombinant Mouse Mediator of RNA polymerase II transcription subunit 23 (Med23), partial

  • 中文名称：
    小鼠Med23重组蛋白
  • 货号：
    CSB-YP772173MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Med23重组蛋白
  • 货号：
    CSB-EP772173MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Med23重组蛋白
  • 货号：
    CSB-EP772173MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Med23重组蛋白
  • 货号：
    CSB-BP772173MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Med23重组蛋白
  • 货号：
    CSB-MP772173MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Med23
  • Uniprot No.：
    Q80YQ2
  • 别名：
    Med23; Crsp3; Kiaa1216; Sur2; Mediator of RNA polymerase II transcription subunit 23; Cofactor required for Sp1 transcriptional activation subunit 3; CRSP complex subunit 3; Mediator complex subunit 23; Protein sur-2 homolog; mSur-2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Also required for transcriptional activation subsequent to the assembly of the pre-initiation complex. Required for transcriptional activation by adenovirus E1A protein. Required for ELK1-dependent transcriptional activation in response to activated Ras signaling.
  • 基因功能参考文献：
    1. MED23 constitutes a molecular node in the regulatory network of anabolic bone formation and related diseases. PMID: 27033977
    2. Med23 contributes to controlling T-cell activation at the transcriptional level and prevents the development of autoimmunity. PMID: 25301163
    3. The hepatic Med23 deletion impaired the Mediator and RNAPII recruitment and attenuated the expression of FOXO1 target genes. PMID: 25223702
    4. Data show that Kruppel-like transcription factors KLF2 expression is decreased in mediator complex Med23 null thymocytes. PMID: 25054639
    5. Mediator Med23 deficiency enhances neural differentiation of murine embryonic stem cells through modulating BMP signaling. PMID: 25564654
    6. Reduced expression of MED23 inhibits cell apoptosis by downregulation of Bax, activated Caspase 3, activated Caspase 9 and upregulation of cyclinD1 and Bcl2. PMID: 23625751
    7. Data show tha tMed23 deficiency in fibroblasts selectively inhibited the oncogenic transformation induced by Ras. PMID: 22988093
    8. Mediator MED23 controls the cell fate preference that directs differentiation into smooth muscle cells (SMCs) or adipocytes PMID: 22972934
    9. MED23 regulates a subset of hnRNP L-targeted alternative splicing (AS) and alternative cleavage and polyadenylation (APA) events. PMID: 22264826
    10. MED23 Mediator controls Egr1 gene and stimulates Pol II initiation at a step subsequent to preinitiation complex assembly PMID: 15749018
    11. Data show that Med23 knockout nearly eliminates Egr1 transcription in embryonic stem cells, but not in fibroblasts. PMID: 19417216
    12. Results suggest that Med23 serves as a critical link transducing insulin signaling to the transcriptional cascade during adipocyte differentiation. PMID: 19460352

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Mediator complex subunit 23 family
  • 数据库链接：

    KEGG: mmu:70208

    STRING: 10090.ENSMUSP00000090316

    UniGene: Mm.28020

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