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  4. Recombinant Mouse MHC class II regulatory factor RFX1 (Rfx1), partial

Recombinant Mouse MHC class II regulatory factor RFX1 (Rfx1), partial

  • 中文名称：
    小鼠Rfx1重组蛋白
  • 货号：
    CSB-YP019610MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Rfx1重组蛋白
  • 货号：
    CSB-EP019610MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Rfx1重组蛋白
  • 货号：
    CSB-EP019610MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Rfx1重组蛋白
  • 货号：
    CSB-BP019610MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Rfx1重组蛋白
  • 货号：
    CSB-MP019610MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Rfx1
  • Uniprot No.：
    P48377
  • 别名：
    Rfx1; MHC class II regulatory factor RFX1; Regulatory factor X 1; Transcription factor RFX1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Regulatory factor essential for MHC class II genes expression. Binds to the X boxes of MHC class II genes.
  • 基因功能参考文献：
    1. Results show that reduced miRNA-124 improved microglia activation and up-regulated its downstream target RFX1, indicating that RFX1, as one of the target transcripts, facilitates microglial activation by miR-124 regulation; identified the binding site through which RFX1 directly regulates ApoE, may explain the missing link between decreased miRNA-124 and ineffective Abeta uptaking during aging. PMID: 28003160
    2. regulatory factor 1 directly regulates CD44 expression in glioblastoma PMID: 24526308
    3. RFX1 may have negative effect on cell proliferation of Sertoli cells via modulating Spata4 expression levels by binding the conserved 14-bp cis-elements of Spata4 promoter. PMID: 24146794
    4. Rfx1 could be an indicator of progression from Barrett's esophagus to adenocarcinoma. PMID: 21935353
    5. These results suggest a significant expression of RFX1 proteins in the mammalian brain. PMID: 21744337
    6. RFX1 may negatively regulate the self-renewal of GBM-SCs through modulating FGF-1B and FGF1 expression levels by binding the 18-bp cis-elements of the F1B promoter. PMID: 20189986
    7. RFX1 may play roles in haploid cells during mouse spermatogenesis PMID: 19596083
    8. RFX1 mediates the immediate early response of the Id2 gene by serum stimulation and suggest that the function of RFX1 is regulated intramolecularly in its suppression in growth-arrested cells. PMID: 17630394
    9. RFX1 regulates expression of genes that are essential for early embryonic development/survival and that RFX1 function can not be compensated by other RFX1 family members. PMID: 19559676

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    RFX family
  • 数据库链接：

    KEGG: mmu:19724

    STRING: 10090.ENSMUSP00000005600

    UniGene: Mm.7892

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